Detailed information NTG0416023

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: H7792_RS08420
• Genome accession: NZ_CP060643
• Coordinates: 1727039..1729594 (-)
• Length: 851 a.a.
• NCBI ID: WP_136020998.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY416
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1722039..1734594

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7792_RS08385 (H7792_08350)	-	1723126..1723299 (+)	174	WP_000694577.1	hypothetical protein	-
H7792_RS08390 (H7792_08355)	-	1723305..1723478 (+)	174	WP_014635784.1	hypothetical protein	-
H7792_RS08395 (H7792_08360)	-	1723480..1723989 (+)	510	WP_002992482.1	hypothetical protein	-
H7792_RS08400 (H7792_08365)	-	1724063..1724551 (+)	489	WP_023080239.1	hypothetical protein	-
H7792_RS08405 (H7792_08370)	-	1724982..1725317 (+)	336	WP_228650347.1	DUF1492 domain-containing protein	-
H7792_RS08410 (H7792_08375)	-	1725292..1725675 (+)	384	WP_010922771.1	ArpU family phage packaging/lysis transcriptional regulator	-
H7792_RS08415 (H7792_08380)	-	1725876..1726424 (+)	549	WP_228650348.1	hypothetical protein	-
H7792_RS08420 (H7792_08385)	hexA	1727039..1729594 (-)	2556	WP_136020998.1	DNA mismatch repair protein MutS	Machinery gene
H7792_RS08425	-	1729581..1729787 (-)	207	WP_032465308.1	YlbF family regulator	-
H7792_RS08430 (H7792_08395)	argR	1729930..1730367 (-)	438	WP_002982171.1	arginine repressor	-
H7792_RS08435 (H7792_08400)	argS	1730658..1732349 (+)	1692	WP_002991367.1	arginine--tRNA ligase	-
H7792_RS08440 (H7792_08405)	-	1732437..1732745 (+)	309	WP_002991370.1	bacteriocin immunity protein	-
H7792_RS08445 (H7792_08410)	-	1732772..1733644 (-)	873	WP_002982164.1	YitT family protein	-
H7792_RS08450 (H7792_08415)	-	1733687..1734565 (-)	879	WP_002991372.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95475.95 Da
• Isoelectric Point: 4.9487

>NTDB_id=416023 H7792_RS08420 WP_136020998.1 1727039..1729594(-) (hexA) [Streptococcus pyogenes strain TSPY416]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQESGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISVPSQV
DSSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=416023 H7792_RS08420 WP_136020998.1 1727039..1729594(-) (hexA) [Streptococcus pyogenes strain TSPY416]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGAAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATTCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCCGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGATCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGCACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTGGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGTCCCTTCACAAGTT
GATTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain III (MutS_III) (256-546)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.563	100	0.716
mutS	Pseudomonas stutzeri strain ATCC 17587	37.193	100	0.374