Detailed information NTG0415883

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3T11_RS11170
• Genome accession: NZ_CP047780
• Coordinates: 2311903..2312946 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_1539
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2306903..2317946

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3T11_RS11140 (E3T11_11140)	-	2307329..2307439 (+)	111	WP_001790257.1	hypothetical protein	-
E3T11_RS11145 (E3T11_11145)	-	2307468..2307881 (+)	414	WP_160188160.1	hypothetical protein	-
E3T11_RS11150 (E3T11_11150)	-	2308312..2309298 (-)	987	WP_000999713.1	FUSC family protein	-
E3T11_RS11155 (E3T11_11155)	map	2309829..2310587 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3T11_RS11160 (E3T11_11160)	-	2310804..2311190 (+)	387	WP_001110179.1	hypothetical protein	-
E3T11_RS11165 (E3T11_11165)	liaF	2311205..2311906 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3T11_RS11170 (E3T11_11170)	vraS	2311903..2312946 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3T11_RS11175 (E3T11_11175)	vraR	2312936..2313565 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
E3T11_RS11180 (E3T11_11180)	-	2313677..2314894 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
E3T11_RS11185 (E3T11_11185)	-	2315172..2315447 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3T11_RS11190 (E3T11_11190)	-	2315454..2315918 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3T11_RS11195 (E3T11_11195)	-	2316065..2316265 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3T11_RS11200 (E3T11_11200)	-	2316268..2317524 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=415883 E3T11_RS11170 WP_001017131.1 2311903..2312946(+) (vraS) [Staphylococcus aureus strain UP_1539]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=415883 E3T11_RS11170 WP_001017131.1 2311903..2312946(+) (vraS) [Staphylococcus aureus strain UP_1539]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1