Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   GU336_RS00660 Genome accession   NZ_CP047616
Coordinates   124089..125336 (-) Length   415 a.a.
NCBI ID   WP_096039855.1    Uniprot ID   A0A290PYB4
Organism   Lactococcus raffinolactis strain Lr_19_5     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 119089..130336
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GU336_RS00625 (GU336_00630) - 119584..120330 (+) 747 WP_167838231.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  GU336_RS00630 (GU336_00635) - 120323..120613 (+) 291 WP_061775129.1 GIY-YIG nuclease family protein -
  GU336_RS00635 (GU336_00640) - 120674..120898 (-) 225 WP_167838232.1 DUF1797 family protein -
  GU336_RS00640 (GU336_00645) - 120959..122290 (-) 1332 WP_138492204.1 glycosyltransferase family 4 protein -
  GU336_RS00645 (GU336_00650) - 122390..123388 (-) 999 WP_061775126.1 glycosyltransferase -
  GU336_RS00655 (GU336_00660) - 123797..124048 (+) 252 WP_061775125.1 hypothetical protein -
  GU336_RS00660 (GU336_00665) htrA 124089..125336 (-) 1248 WP_096039855.1 trypsin-like peptidase domain-containing protein Regulator
  GU336_RS00665 (GU336_00670) rlmH 125633..126109 (+) 477 WP_096039856.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GU336_RS00670 (GU336_00675) - 126106..126768 (+) 663 WP_061775122.1 DNA alkylation repair protein -
  GU336_RS00675 (GU336_00680) - 126833..127510 (+) 678 WP_167838233.1 YoaK family protein -
  GU336_RS00680 (GU336_00685) guaB 127730..129211 (+) 1482 WP_167838234.1 IMP dehydrogenase -
  GU336_RS00685 (GU336_00690) - 129480..129638 (+) 159 Protein_121 CAT RNA binding domain-containing protein -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43435.75 Da        Isoelectric Point: 5.3584

>NTDB_id=414625 GU336_RS00660 WP_096039855.1 124089..125336(-) (htrA) [Lactococcus raffinolactis strain Lr_19_5]
MKNSKKTAVKLIAAGIIGGAVSLGGNIAYDHFTGDTPIKTNQTSTTKVSDVSYKVSSSTTKAIAKVSDAVVSVINYQKAS
SSNSLDDLFGDSSSTNKDNAKEQPAGEGSGVIYKKDGDYAYIVTNNHVVDGASSLEIMLSNGNKVKGTLVGKDAYSDLAV
IKIPSKEVTKVAEFGDSSKLTVGEPAIAIGSPLGSEYANSATEGIISSLSRKVIMQNESNETVNVNAIQTDAAINPGNSG
GALINVEGQVIGINSSKISATGSSSRDVSVEGMGFAIPSNDVVEIISKLEKDGEIKRPALGVQMVDLTGINSRYIDELKL
PDSVTAGVVVAKVQKGLPADTAGLKKYDVITKIGDTKVTTSTELQSALYKYNVGDEMKVTYYREGKEKTATVKLATSSDK
LDFKDAESAKAEQDK

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=414625 GU336_RS00660 WP_096039855.1 124089..125336(-) (htrA) [Lactococcus raffinolactis strain Lr_19_5]
ATGAAAAATAGTAAAAAAACTGCTGTAAAATTAATCGCTGCTGGGATTATCGGTGGTGCTGTTTCATTAGGTGGTAATAT
CGCCTACGACCATTTTACGGGTGATACGCCTATCAAGACGAATCAAACCAGCACGACCAAAGTGTCTGATGTTTCTTATA
AAGTATCAAGTAGTACAACTAAAGCGATTGCCAAAGTATCTGATGCCGTTGTCTCTGTCATTAATTATCAAAAAGCGTCG
TCAAGCAACTCATTAGATGATCTTTTTGGTGATAGCTCATCTACTAATAAGGATAATGCTAAAGAACAACCCGCAGGTGA
AGGCTCTGGTGTCATCTATAAAAAAGACGGTGATTACGCTTATATCGTTACCAACAACCACGTCGTTGATGGTGCAAGCT
CACTAGAAATCATGCTATCAAATGGTAATAAGGTCAAAGGTACTTTAGTCGGGAAAGATGCTTATAGCGATTTAGCGGTC
ATTAAAATTCCATCTAAAGAAGTCACAAAAGTTGCTGAATTCGGCGATTCTTCCAAGCTTACTGTTGGAGAGCCCGCCAT
TGCTATCGGCTCTCCTCTAGGAAGTGAATATGCTAACTCAGCCACTGAAGGGATTATCTCTAGTCTATCACGCAAGGTTA
TCATGCAAAATGAAAGCAATGAAACCGTCAATGTTAATGCCATTCAAACCGATGCCGCGATTAATCCCGGCAACTCTGGT
GGTGCTTTGATCAACGTCGAAGGTCAAGTCATCGGCATCAACTCAAGCAAGATCTCTGCAACAGGTTCATCTTCAAGAGA
TGTTTCTGTTGAAGGGATGGGCTTCGCCATTCCATCCAATGATGTCGTTGAAATTATCAGTAAACTCGAAAAAGACGGTG
AAATCAAGCGCCCAGCACTCGGCGTGCAAATGGTTGATCTCACTGGCATTAACTCGCGCTATATCGACGAGCTCAAACTT
CCTGACTCTGTCACAGCAGGTGTCGTGGTCGCCAAAGTTCAAAAAGGTCTACCAGCCGACACTGCGGGACTTAAAAAATA
TGATGTGATCACGAAAATTGGTGATACTAAAGTGACAACTAGTACTGAACTTCAAAGCGCGCTTTACAAATACAATGTCG
GAGACGAGATGAAAGTCACTTACTACCGTGAGGGTAAAGAAAAAACAGCAACTGTTAAACTTGCTACATCCTCTGATAAG
TTAGACTTTAAAGATGCTGAGTCTGCCAAGGCTGAACAAGATAAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(263-398)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(298-394)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A290PYB4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

56.127

98.313

0.552
  htrA Streptococcus mutans UA159

57.979

90.602

0.525
  htrA Streptococcus mitis NCTC 12261

51.99

96.867

0.504
  htrA Streptococcus pneumoniae Rx1

55.493

85.542

0.475
  htrA Streptococcus pneumoniae D39

55.493

85.542

0.475
  htrA Streptococcus pneumoniae R6

55.493

85.542

0.475
  htrA Streptococcus pneumoniae TIGR4

55.493

85.542

0.475

Multiple sequence alignment