Detailed information NTG0041406

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HMPREF0833_RS08450
• Genome accession: NC_015678
• Coordinates: 1808478..1809212 (+)
• Length: 244 a.a.
• NCBI ID: WP_041818412.1
• Uniprot ID: -
• Organism: Streptococcus parasanguinis ATCC 15912
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1803478..1814212

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0833_RS08430 (HMPREF0833_11682)	-	1804250..1805104 (+)	855	WP_037617561.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
HMPREF0833_RS08435 (HMPREF0833_11683)	-	1805206..1805499 (+)	294	WP_003004348.1	hypothetical protein	-
HMPREF0833_RS08440 (HMPREF0833_11684)	groES	1805629..1805910 (+)	282	WP_041818410.1	co-chaperone GroES	-
HMPREF0833_RS08445 (HMPREF0833_11685)	groL	1805932..1807557 (+)	1626	WP_013904507.1	chaperonin GroEL	-
HMPREF0833_RS08450 (HMPREF0833_11686)	comE/blpR	1808478..1809212 (+)	735	WP_041818412.1	response regulator transcription factor	Regulator
HMPREF0833_RS08455 (HMPREF0833_11687)	-	1809226..1810530 (+)	1305	WP_142743558.1	sensor histidine kinase	-
HMPREF0833_RS11080	-	1810486..1810671 (-)	186	WP_080559870.1	hypothetical protein	-
HMPREF0833_RS08460 (HMPREF0833_11688)	-	1810819..1811499 (+)	681	WP_013904510.1	ABC transporter ATP-binding protein	-
HMPREF0833_RS08465 (HMPREF0833_11689)	-	1811496..1812203 (+)	708	WP_013904511.1	hypothetical protein	-
HMPREF0833_RS08475 (HMPREF0833_11690)	-	1812744..1814015 (-)	1272	WP_041818415.1	replication-associated recombination protein A	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28187.46 Da
• Isoelectric Point: 6.6114

>NTDB_id=41406 HMPREF0833_RS08450 WP_041818412.1 1808478..1809212(+) (comE/blpR) [Streptococcus parasanguinis ATCC 15912]
MLKIFVLEDEWIQQSRIEAVLQDLIRQKSLQCKALEVFGKSSQLLDAITERGAHHLFFLDIEIKGEEKKGLEIAKEIRKK
DPHATIVFVTTHSEFMPITFQYKVAALDFIDKTLGEEEFRERISSAIDYTLEQAGTTIAQDAFTFESAMARVQVPFNKIL
YVETSPTIHKVILHTQEERLEFYASIADIEKADPRLYRCHRSFVVNPQNITKIDKEAKKAFFENGDNCLISRTKYRGLLE
ALKK

Nucleotide

• Length: 735 bp

>NTDB_id=41406 HMPREF0833_RS08450 WP_041818412.1 1808478..1809212(+) (comE/blpR) [Streptococcus parasanguinis ATCC 15912]
TTGTTGAAGATTTTTGTGTTAGAAGATGAATGGATCCAACAATCGCGTATCGAAGCGGTCTTGCAGGATCTCATCCGTCA
AAAATCCTTGCAATGCAAAGCGCTAGAAGTGTTTGGGAAGTCAAGCCAGTTGCTGGATGCTATCACAGAGAGAGGCGCTC
ATCACCTATTCTTTTTAGATATCGAGATTAAAGGTGAGGAGAAAAAAGGTCTGGAGATCGCAAAAGAGATTCGTAAGAAA
GATCCCCATGCGACCATTGTCTTTGTCACCACCCACTCTGAATTCATGCCCATTACCTTTCAGTACAAAGTGGCTGCCTT
GGATTTTATTGATAAAACGCTGGGTGAGGAAGAGTTCAGAGAGAGAATCAGCTCAGCCATCGACTATACCTTGGAGCAAG
CTGGGACCACGATTGCGCAAGATGCCTTTACATTTGAGAGTGCGATGGCGCGTGTACAAGTTCCTTTTAATAAGATTTTG
TATGTTGAAACGTCTCCAACCATTCACAAGGTCATTTTACACACCCAGGAAGAGCGCTTGGAATTTTACGCTAGTATTGC
CGATATCGAAAAAGCAGATCCCCGCTTGTATCGGTGCCACCGCTCCTTTGTGGTGAATCCGCAAAATATTACGAAGATTG
ATAAAGAAGCCAAGAAAGCTTTTTTTGAAAATGGGGACAATTGCTTGATCTCACGGACCAAGTACAGAGGCTTACTGGAA
GCTTTGAAAAAATAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.649	97.951	0.545
comE/comE1	Streptococcus equinus JB1	46.091	99.59	0.459
comE/comE2	Streptococcus gordonii strain NCTC7865	40.081	100	0.406
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.081	100	0.406
comE/comE2	Streptococcus equinus JB1	38.057	100	0.385
comE	Streptococcus pneumoniae TIGR4	36	100	0.369
comE	Streptococcus mitis NCTC 12261	36	100	0.369
comE	Streptococcus mitis SK321	36	100	0.369
comE	Streptococcus infantis strain Atu-4	36	100	0.369
comE	Streptococcus pneumoniae Rx1	36	100	0.369
comE	Streptococcus pneumoniae D39	36	100	0.369
comE	Streptococcus pneumoniae R6	36	100	0.369