Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   HMPREF0833_RS00420 Genome accession   NC_015678
Coordinates   65951..68215 (-) Length   754 a.a.
NCBI ID   WP_041818103.1    Uniprot ID   -
Organism   Streptococcus parasanguinis ATCC 15912     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 60951..73215
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0833_RS00400 (HMPREF0833_10068) - 63334..63636 (-) 303 WP_013903221.1 DUF1827 family protein -
  HMPREF0833_RS00405 (HMPREF0833_10069) - 63704..64153 (-) 450 WP_041818100.1 NUDIX hydrolase -
  HMPREF0833_RS00410 (HMPREF0833_10070) - 64331..65233 (+) 903 WP_003017575.1 YafY family protein -
  HMPREF0833_RS00415 (HMPREF0833_10071) - 65288..65902 (+) 615 WP_003017581.1 GyrI-like domain-containing protein -
  HMPREF0833_RS00420 (HMPREF0833_10072) clpE 65951..68215 (-) 2265 WP_041818103.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  HMPREF0833_RS00425 (HMPREF0833_10073) - 68464..68694 (+) 231 WP_003005989.1 DUF1797 family protein -
  HMPREF0833_RS00430 (HMPREF0833_10074) - 68860..69714 (+) 855 WP_013903224.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  HMPREF0833_RS00435 (HMPREF0833_10075) - 69728..70501 (+) 774 WP_013903225.1 HAD-IIB family hydrolase -
  HMPREF0833_RS00440 (HMPREF0833_10076) - 70554..71429 (+) 876 WP_013903226.1 NAD(P)H-hydrate dehydratase -
  HMPREF0833_RS00445 (HMPREF0833_10077) - 71438..72892 (+) 1455 WP_013903227.1 glycoside hydrolase family 32 protein -

Sequence

Protein


Download         Length: 754 a.a.        Molecular weight: 84143.27 Da        Isoelectric Point: 5.1172

>NTDB_id=41362 HMPREF0833_RS00420 WP_041818103.1 65951..68215(-) (clpE) [Streptococcus parasanguinis ATCC 15912]
MLCQNCKINESTIHLYTNVNGHQQQVDLCQNCYKIMKTDPNNSFLKGMTQRSQLTGDPFEDFFNNLGNFQSPQEPQTPPT
QSGVSYGGGGYGQNNNRSGSQDPRQARPQKPKGLLEEFGINVTEIARKGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRQREDVILFIDEIHEIVGAG
SAGEGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVHYTD
GAIEAAAILSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATREEDFEKAAYFRDQIAKYK
EMQGQHVTDQETPVISEKTIEHIVEQKTNIPVGDLKEKEQSQLINLASDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLVLL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKAEANVGFGAAREGRTNSVLGELGNFFSPEFMN
RFDGIIEFQPLSKENLLQIVTLMLDEVNQRLAQNEIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDYYLE
HPSEKQLKAVMTSNGNISIKATKKAEKNTSEKED

Nucleotide


Download         Length: 2265 bp        

>NTDB_id=41362 HMPREF0833_RS00420 WP_041818103.1 65951..68215(-) (clpE) [Streptococcus parasanguinis ATCC 15912]
ATGCTTTGTCAAAATTGTAAAATAAATGAATCAACCATCCATTTATATACAAATGTAAATGGACACCAGCAGCAAGTAGA
CCTCTGTCAAAATTGCTATAAAATTATGAAAACAGACCCAAATAACAGCTTCTTGAAAGGCATGACCCAACGGAGCCAAC
TGACTGGAGATCCCTTCGAAGATTTCTTCAATAACCTTGGAAACTTCCAAAGTCCACAAGAACCTCAAACACCTCCAACT
CAATCTGGAGTCAGTTATGGAGGTGGCGGTTACGGCCAAAACAATAACCGTAGCGGCAGTCAAGACCCACGTCAAGCTCG
CCCTCAAAAGCCTAAAGGACTATTAGAAGAATTCGGTATCAATGTCACAGAAATTGCCCGCAAAGGGGATATTGACCCTG
TCATCGGCCGTGATGAAGAAATTATCCGTGTCATCGAAATTCTCAACCGTCGAACCAAGAACAATCCGGTTCTGATCGGA
GAACCTGGGGTCGGAAAAACTGCCGTTGTGGAAGGCTTGGCCCAAAAAATCGTCGATGGAGACGTTCCTCATAAATTGCA
AGGAAAAGAAGTCATCCGCCTAGACGTCGTCAGCCTCGTTCAAGGCACAGGTATTCGTGGTCAATTCGAAGAACGCATGC
AAAAATTAATGGATGAAATTCGTCAACGTGAAGATGTGATTCTTTTCATCGACGAAATCCATGAAATTGTTGGCGCAGGA
TCTGCTGGCGAAGGCAATATGGACGCTGGAAATATCCTCAAACCAGCCTTGGCGCGCGGTGAACTCCAATTGGTCGGTGC
TACTACCCTCAATGAATACCGCATCATTGAAAAAGATGCAGCCTTGGAACGTCGGATGCAACCCGTTAAGGTCGATGAGC
CAACGGTTGAAGAAACCATCACCATCCTCAAAGGCATCCAGAAAAAATACGAAGACTACCACCACGTCCACTATACAGAC
GGGGCCATCGAAGCGGCAGCTATTCTTTCAAACCGCTACATCCAAGATCGCTTCCTGCCAGACAAGGCCATTGATTTGTT
GGATGAAGCCGGGTCTAAAATGAACCTGACTCTGAACTTTGTGGATCCAAAAGTTATCGACCAGCGCTTGATTGAAGCGG
AAAACCTCAAAGCTCAAGCGACCCGCGAAGAAGACTTTGAAAAAGCAGCCTACTTCCGCGACCAAATCGCAAAATATAAG
GAAATGCAAGGTCAACATGTCACCGATCAGGAAACCCCTGTCATCAGCGAAAAAACGATTGAACACATCGTTGAACAAAA
GACCAATATTCCTGTTGGTGATTTGAAAGAAAAAGAACAATCTCAATTGATCAATCTGGCTTCTGATTTGAAAGCTCATG
TGATTGGTCAAGACGATGCAGTAGATAAAATCGCGAAAGCCATTCGACGCAATCGTGTCGGCCTAGGATCTCCTAACCGT
CCGATCGGAAGCTTCCTCTTTGTCGGACCAACCGGTGTCGGAAAGACCGAATTGTCTAAACAATTGGCGATCGAGCTCTT
TGGCTCTGCAGATAATATGATCCGCTTTGATATGAGCGAATACATGGAAAAACATAGCGTAGCGAAACTAGTCGGAGCTC
CTCCGGGCTATGTGGGCTACGATGAAGCTGGACAACTAACGGAAAAGGTACGTCGCAATCCATACTCTCTCGTTTTATTG
GATGAAGTGGAAAAAGCCCATCCAGATGTCATGCACATGTTCTTGCAAGTCTTGGATGATGGCCGTTTGACAGATGGTCA
AGGCCGTACCGTCAGCTTTAAAGATACCATTATCATCATGACCTCTAATGCTGGAACCGGCAAGGCTGAGGCCAATGTTG
GTTTTGGAGCTGCTCGCGAAGGTCGCACCAACTCCGTACTTGGAGAACTCGGGAACTTCTTTAGCCCTGAATTCATGAAC
CGTTTTGATGGCATCATTGAATTCCAACCTCTATCAAAAGAAAACCTTCTTCAAATCGTTACCCTCATGCTGGATGAAGT
CAATCAACGTCTCGCACAAAATGAGATTCATCTGGATGTGACAGAGAAGGTCAAAGAAAAGTTGGTCGATCTGGGATACG
ATCCAAAAATGGGGGCCCGCCCACTCCGTCGTACCATCCAAGACCATATCGAAGATGCCATTACAGATTATTACCTAGAA
CATCCAAGTGAAAAACAACTCAAAGCAGTCATGACCAGCAATGGGAATATTAGCATCAAAGCTACTAAAAAAGCAGAAAA
GAACACTTCTGAAAAGGAAGACTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(480-643)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(651-726)

AAA lid domain (AAA_lid_9)

(295-392)

ATPase family associated with various cellular activities (AAA) (AAA)

(157-270)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

87.135

100

0.871
  clpE Streptococcus pneumoniae D39

87.135

100

0.871
  clpE Streptococcus pneumoniae R6

87.135

100

0.871
  clpE Streptococcus pneumoniae TIGR4

87.135

100

0.871
  clpE Streptococcus mutans UA159

83.245

100

0.837
  clpC Lactococcus lactis subsp. cremoris KW2

75.462

100

0.759
  clpC Bacillus subtilis subsp. subtilis str. 168

52.986

86.605

0.459
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.699

86.472

0.412
  clpC Streptococcus pneumoniae Rx1

47.84

82.891

0.397
  clpC Streptococcus pneumoniae D39

47.84

82.891

0.397
  clpC Streptococcus pneumoniae TIGR4

47.68

82.891

0.395
  clpC Streptococcus mutans UA159

46.88

82.891

0.389
  clpC Streptococcus thermophilus LMD-9

47.03

82.626

0.389
  clpC Streptococcus thermophilus LMG 18311

46.785

82.493

0.386

Multiple sequence alignment