Detailed information NTG0409130

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: GP482_RS07020
• Genome accession: NZ_CP046875
• Coordinates: 1440691..1441425 (-)
• Length: 244 a.a.
• NCBI ID: WP_158914534.1
• Uniprot ID: A0AAE6R599
• Organism: Streptococcus ruminicola strain CNU_77-61
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1435691..1446425

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GP482_RS06990 (GP482_06990)	-	1436003..1436941 (-)	939	WP_158914530.1	3'-5' exoribonuclease YhaM family protein	-
GP482_RS06995 (GP482_06995)	-	1436931..1438205 (-)	1275	WP_006531897.1	DNA recombination protein RmuC	-
GP482_RS07000 (GP482_07000)	-	1438207..1438839 (-)	633	WP_158914532.1	thiamine diphosphokinase	-
GP482_RS07005 (GP482_07005)	rpe	1438832..1439494 (-)	663	WP_006531895.1	ribulose-phosphate 3-epimerase	-
GP482_RS07010 (GP482_07010)	rsgA	1439501..1440373 (-)	873	WP_006531894.1	ribosome small subunit-dependent GTPase A	-
GP482_RS07020 (GP482_07020)	comE/comE2	1440691..1441425 (-)	735	WP_158914534.1	LytTR family DNA-binding domain-containing protein	Regulator
GP482_RS07025 (GP482_07025)	comD/comD3	1442087..1443460 (-)	1374	WP_254058924.1	GHKL domain-containing protein	Regulator
GP482_RS09650	comD/comD3	1443453..1444244 (-)	792	WP_240187156.1	GHKL domain-containing protein	Regulator
GP482_RS07035 (GP482_07035)	-	1444994..1445287 (-)	294	WP_158914536.1	bacteriocin immunity protein	-
GP482_RS07040 (GP482_07040)	-	1445315..1445620 (-)	306	WP_158914537.1	bacteriocin immunity protein	-
GP482_RS07045 (GP482_07045)	-	1445633..1445782 (-)	150	WP_039696228.1	hypothetical protein	-
GP482_RS07050 (GP482_07050)	comC/comC1	1446045..1446197 (+)	153	WP_158914538.1	hypothetical protein	Regulator

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28885.15 Da
• Isoelectric Point: 6.5012

>NTDB_id=409130 GP482_RS07020 WP_158914534.1 1440691..1441425(-) (comE/comE2) [Streptococcus ruminicola strain CNU_77-61]
MIDIYVLEDNVNQQFRIEKMIGDLLETNQWETRHFDLFSEPDYLTNLVEESFPQIFFLDIDIHGDNTKGIEVAKAIREKS
RTATIVFVTTHSEFMLLTYRAQVSALDFIDKTDKDDAIKDNLKKCLQKVFEDQGFNIPKEIFVFENNKTKIRIPLEDILY
FETAESHRLKLITKTGQRHFYGSIKEVMQANQKLFRCHKSYLINLNNIVRLDKKEGLVYFDDDKACYVSRKYIKDLRSKM
ENLK

Nucleotide

• Length: 735 bp

>NTDB_id=409130 GP482_RS07020 WP_158914534.1 1440691..1441425(-) (comE/comE2) [Streptococcus ruminicola strain CNU_77-61]
ATGATTGATATCTATGTATTAGAAGATAATGTAAATCAGCAGTTCCGTATTGAAAAAATGATTGGAGATTTACTCGAGAC
AAATCAGTGGGAAACTCGTCATTTTGATTTATTTAGTGAACCTGATTATTTAACTAACCTAGTTGAGGAGTCTTTTCCTC
AAATTTTTTTCCTGGATATTGATATTCATGGAGATAATACCAAAGGAATTGAAGTGGCTAAGGCGATAAGGGAAAAATCA
CGCACAGCGACAATTGTTTTTGTGACGACTCACTCTGAATTCATGTTATTAACTTATCGAGCGCAAGTTAGTGCACTTGA
TTTTATTGATAAAACAGATAAAGATGATGCGATAAAAGATAACTTAAAAAAATGCTTGCAAAAGGTCTTTGAGGACCAAG
GTTTTAACATTCCTAAGGAAATATTTGTTTTTGAAAATAACAAAACGAAAATCCGCATTCCCTTGGAAGATATCCTTTAT
TTTGAAACCGCGGAAAGTCATCGCCTGAAGTTGATTACAAAAACTGGACAACGTCATTTTTATGGTTCAATCAAAGAAGT
GATGCAAGCTAATCAGAAATTATTTAGATGTCATAAATCATATCTGATTAACCTAAATAATATTGTTAGGTTAGATAAAA
AAGAAGGTTTGGTTTATTTTGACGATGATAAAGCCTGTTATGTTTCTAGAAAATATATCAAAGACTTAAGGTCAAAAATG
GAAAATCTGAAATAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (19-120)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	99.59	100	0.996
comE/comE1	Streptococcus equinus JB1	45.041	99.18	0.447
comE/blpR	Streptococcus mutans UA159	40.664	98.77	0.402
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.5	100	0.381
comE/comE2	Streptococcus gordonii strain NCTC7865	37.5	100	0.381
comE	Streptococcus pneumoniae R6	35.039	100	0.365
comE	Streptococcus pneumoniae TIGR4	35.039	100	0.365
comE	Streptococcus pneumoniae Rx1	35.039	100	0.365
comE	Streptococcus pneumoniae D39	35.039	100	0.365