Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   GOM46_RS01115 Genome accession   NZ_CP046525
Coordinates   222289..223227 (+) Length   312 a.a.
NCBI ID   WP_235083711.1    Uniprot ID   -
Organism   Streptococcus infantis strain SO     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 210915..253523 222289..223227 within 0


Gene organization within MGE regions


Location: 210915..253523
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM46_RS01060 (GOM46_01045) - 210915..212066 (-) 1152 WP_235083702.1 tyrosine-type recombinase/integrase -
  GOM46_RS01065 (GOM46_01050) - 212118..212456 (-) 339 WP_235083703.1 DUF771 domain-containing protein -
  GOM46_RS01070 (GOM46_01055) - 212521..213756 (-) 1236 WP_235083704.1 replication protein RepA -
  GOM46_RS01075 (GOM46_01060) - 213905..214522 (-) 618 WP_235083705.1 hypothetical protein -
  GOM46_RS01080 (GOM46_01065) - 214519..215688 (-) 1170 WP_235083706.1 FtsK/SpoIIIE domain-containing protein -
  GOM46_RS01085 (GOM46_01070) - 215692..216048 (-) 357 WP_235083707.1 hypothetical protein -
  GOM46_RS01090 (GOM46_01075) - 216280..216825 (+) 546 WP_235083708.1 hypothetical protein -
  GOM46_RS01095 (GOM46_01080) - 216841..217179 (-) 339 WP_235083709.1 helix-turn-helix domain-containing protein -
  GOM46_RS01100 (GOM46_01085) - 217344..219962 (+) 2619 WP_235083710.1 SEC10/PgrA surface exclusion domain-containing protein -
  GOM46_RS01105 (GOM46_01090) nagA 220543..221694 (+) 1152 WP_006150219.1 N-acetylglucosamine-6-phosphate deacetylase -
  GOM46_RS01110 (GOM46_01095) - 221860..222237 (+) 378 WP_006150119.1 DUF1033 family protein -
  GOM46_RS01115 (GOM46_01100) comGA/cglA/cilD 222289..223227 (+) 939 WP_235083711.1 competence type IV pilus ATPase ComGA Machinery gene
  GOM46_RS01120 (GOM46_01105) comGB/cglB 223151..224194 (+) 1044 WP_235083712.1 competence type IV pilus assembly protein ComGB Machinery gene
  GOM46_RS01125 (GOM46_01110) comGC/cglC 224195..224518 (+) 324 WP_235083713.1 competence type IV pilus major pilin ComGC Machinery gene
  GOM46_RS01130 (GOM46_01115) comGD/cglD 224481..224915 (+) 435 WP_029689590.1 competence type IV pilus minor pilin ComGD Machinery gene
  GOM46_RS01135 (GOM46_01120) comGE/cglE 224878..225180 (+) 303 WP_025169999.1 competence type IV pilus minor pilin ComGE Machinery gene
  GOM46_RS01140 (GOM46_01125) comGF/cglF 225143..225604 (+) 462 WP_235083714.1 competence type IV pilus minor pilin ComGF Machinery gene
  GOM46_RS01145 (GOM46_01130) comGG 225582..226019 (+) 438 WP_235083715.1 competence type IV pilus minor pilin ComGG -
  GOM46_RS01150 (GOM46_01135) - 226078..226779 (+) 702 WP_235083716.1 histidine phosphatase family protein -
  GOM46_RS01155 (GOM46_01140) - 226971..228677 (+) 1707 WP_235083717.1 ABC transporter ATP-binding protein -
  GOM46_RS01160 (GOM46_01145) - 228679..230445 (+) 1767 WP_235083718.1 ABC transporter ATP-binding protein -
  GOM46_RS01165 (GOM46_01150) - 230583..231272 (+) 690 WP_070889112.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
  GOM46_RS01170 (GOM46_01155) - 231444..232793 (+) 1350 WP_000018239.1 glucose-6-phosphate isomerase -
  GOM46_RS01175 (GOM46_01160) - 232977..233777 (+) 801 WP_001000837.1 SDR family oxidoreductase -
  GOM46_RS01180 (GOM46_01165) - 233840..235666 (+) 1827 WP_080981318.1 BglG family transcription antiterminator -
  GOM46_RS01185 (GOM46_01170) - 235666..236163 (+) 498 WP_001086645.1 transcriptional regulator GutM -
  GOM46_RS01190 (GOM46_01175) - 236160..236705 (+) 546 WP_001015684.1 PTS glucitol/sorbitol transporter subunit IIC -
  GOM46_RS01195 (GOM46_01180) - 236719..237699 (+) 981 WP_000120696.1 PTS glucitol/sorbitol transporter subunit IIB -
  GOM46_RS01200 (GOM46_01185) - 237797..238168 (+) 372 WP_033585537.1 PTS glucitol/sorbitol transporter subunit IIA -
  GOM46_RS01205 (GOM46_01190) pgi 238365..238841 (+) 477 Protein_214 glucose-6-phosphate isomerase -
  GOM46_RS01210 (GOM46_01195) gltX 238973..240433 (+) 1461 WP_235083719.1 glutamate--tRNA ligase -
  GOM46_RS01215 (GOM46_01200) - 240908..242122 (+) 1215 WP_235083720.1 pyridoxal phosphate-dependent aminotransferase -
  GOM46_RS01220 (GOM46_01205) rpmH 242267..242401 (+) 135 WP_000831905.1 50S ribosomal protein L34 -
  GOM46_RS01225 (GOM46_01210) - 242581..244425 (-) 1845 WP_235083721.1 APC family permease -
  GOM46_RS01230 (GOM46_01215) - 244582..245358 (+) 777 WP_235083722.1 TatD family hydrolase -
  GOM46_RS01235 (GOM46_01220) rnmV 245355..245918 (+) 564 WP_235083723.1 ribonuclease M5 -
  GOM46_RS01240 (GOM46_01225) - 246052..247470 (+) 1419 WP_235083724.1 SseB family protein -
  GOM46_RS01245 (GOM46_01230) - 247561..248277 (+) 717 WP_235084135.1 dimethyladenosine transferase -
  GOM46_RS01250 (GOM46_01235) rsmA 248290..249162 (+) 873 WP_235083725.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
  GOM46_RS01255 (GOM46_01240) rsgA 249164..250042 (+) 879 WP_235083726.1 ribosome small subunit-dependent GTPase A -
  GOM46_RS01260 (GOM46_01245) rpe 250053..250709 (+) 657 WP_235083727.1 ribulose-phosphate 3-epimerase -
  GOM46_RS01265 (GOM46_01250) - 250672..251334 (+) 663 WP_235083728.1 thiamine diphosphokinase -
  GOM46_RS01270 (GOM46_01255) rmuC 251336..252592 (+) 1257 WP_235083729.1 DNA recombination protein RmuC -
  GOM46_RS01275 (GOM46_01260) - 252582..253523 (+) 942 WP_045614706.1 3'-5' exoribonuclease YhaM family protein -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35500.46 Da        Isoelectric Point: 6.5661

>NTDB_id=405036 GOM46_RS01115 WP_235083711.1 222289..223227(+) (comGA/cglA/cilD) [Streptococcus infantis strain SO]
MVQALAQELISLAKKNGAQDIYFVPKNQVYELHMRIGDKRHLIDTYDFEKLGSVISHFKFITGMNVGEKRRSQLGSCDYQ
HDDKVSSLRLSTVGDYRGHESLVIRLLHDQEQELHFWFQNLKELEKGFRQRGLYLFAGPVGSGKTTLMHELAKSLFKGQQ
VMSIEDPVEIKQEEMLQLQLNEAIGLNYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSVRGVY
ERLVELGVSEDELAVVLQGVCYQRLIGGGGIIDFANQNYQEHQANKWNEQIDQLLKEGHITTIQAETEKISH

Nucleotide


Download         Length: 939 bp        

>NTDB_id=405036 GOM46_RS01115 WP_235083711.1 222289..223227(+) (comGA/cglA/cilD) [Streptococcus infantis strain SO]
ATGGTACAAGCACTTGCACAAGAATTGATTAGTCTCGCAAAAAAGAATGGAGCGCAGGACATTTATTTTGTTCCCAAGAA
TCAGGTTTATGAGCTACATATGCGAATTGGAGATAAAAGACATCTAATTGATACCTATGATTTTGAAAAGTTGGGGTCTG
TCATTAGTCACTTTAAGTTTATTACGGGGATGAACGTAGGCGAAAAACGTCGTAGCCAGCTTGGTTCCTGTGACTATCAG
CATGATGACAAGGTTTCTTCACTCCGTTTATCAACTGTAGGAGATTATCGTGGGCATGAGAGTCTAGTTATTCGACTTTT
ACATGACCAAGAACAAGAGTTGCACTTCTGGTTTCAGAACCTTAAGGAACTGGAAAAGGGCTTTAGACAACGCGGGCTTT
ATCTTTTTGCAGGCCCTGTAGGAAGTGGGAAAACGACTCTAATGCATGAGTTAGCTAAGTCATTGTTCAAGGGACAGCAA
GTCATGTCCATTGAAGACCCAGTCGAGATTAAGCAGGAAGAGATGCTACAATTACAACTTAATGAAGCAATTGGGCTGAA
CTATGAAAATTTGATAAAACTCTCCCTACGGCATCGTCCAGACCTTTTAATTATTGGAGAAATTCGGGATAGTGAAACAG
CCCGTGCTGTTGTACGAGCCAGTTTAACAGGGGCTACAGTATTCTCGACTATTCATGCAAAGAGTGTTCGTGGGGTCTAT
GAGCGCCTTGTGGAACTTGGAGTTAGTGAAGATGAACTCGCAGTTGTTTTACAAGGTGTTTGTTACCAGAGACTAATTGG
GGGAGGAGGAATTATCGATTTTGCAAACCAAAATTATCAGGAACACCAGGCAAACAAATGGAATGAACAAATTGACCAAC
TTCTTAAAGAAGGACATATCACTACCATTCAAGCTGAAACGGAGAAAATTAGCCACTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(11-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

83.654

100

0.837
  comGA/cglA/cilD Streptococcus pneumoniae D39

83.654

100

0.837
  comGA/cglA/cilD Streptococcus pneumoniae R6

83.654

100

0.837
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

83.654

100

0.837
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

83.654

100

0.837
  comYA Streptococcus gordonii str. Challis substr. CH1

76.774

99.359

0.763
  comYA Streptococcus mutans UA159

63.987

99.679

0.638
  comYA Streptococcus mutans UA140

63.987

99.679

0.638
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

63.226

99.359

0.628
  comGA Lactococcus lactis subsp. cremoris KW2

55.449

100

0.554
  comGA Latilactobacillus sakei subsp. sakei 23K

43.446

85.577

0.372

Multiple sequence alignment