Detailed information NTG0404559

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GOL67_RS09225
• Genome accession: NZ_CP046476
• Coordinates: 1897800..1898843 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MEI001
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1892800..1903843

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GOL67_RS09195 (GOL67_09250)	-	1893222..1894478 (-)	1257	WP_001793428.1	aminopeptidase	-
GOL67_RS09200 (GOL67_09255)	-	1894481..1894681 (-)	201	WP_000180463.1	DUF1128 family protein	-
GOL67_RS09205 (GOL67_09260)	-	1894828..1895292 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
GOL67_RS09210 (GOL67_09265)	-	1895299..1895574 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
GOL67_RS09215 (GOL67_09270)	-	1895852..1897069 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
GOL67_RS09220 (GOL67_09275)	vraR	1897181..1897810 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
GOL67_RS09225 (GOL67_09280)	vraS	1897800..1898843 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
GOL67_RS09230 (GOL67_09285)	liaF	1898840..1899541 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
GOL67_RS09235 (GOL67_09290)	-	1899556..1899942 (-)	387	WP_001110179.1	hypothetical protein	-
GOL67_RS09240 (GOL67_09295)	map	1900159..1900917 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
GOL67_RS09245 (GOL67_09300)	-	1901448..1902434 (+)	987	WP_031811349.1	aromatic acid exporter family protein	-
GOL67_RS09250 (GOL67_09305)	-	1902924..1903337 (-)	414	WP_001549145.1	hypothetical protein	-
GOL67_RS09255 (GOL67_09310)	-	1903366..1903476 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=404559 GOL67_RS09225 WP_001017131.1 1897800..1898843(-) (vraS) [Staphylococcus aureus strain MEI001]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=404559 GOL67_RS09225 WP_001017131.1 1897800..1898843(-) (vraS) [Staphylococcus aureus strain MEI001]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1