Detailed information NTG0040381

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SPYALAB49_RS02125
• Genome accession: NC_017596
• Coordinates: 401726..403879 (-)
• Length: 717 a.a.
• NCBI ID: WP_014635341.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes Alab49
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 396726..408879

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYALAB49_RS02110 (SPYALAB49_000433)	-	397918..398666 (+)	749	Protein_368	response regulator transcription factor	-
SPYALAB49_RS02115 (SPYALAB49_000434)	-	398667..400001 (+)	1335	WP_014635339.1	sensor histidine kinase	-
SPYALAB49_RS09240 (SPYALAB49_000435)	-	400149..400274 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SPYALAB49_RS02120 (SPYALAB49_000436)	-	400351..401715 (-)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-
SPYALAB49_RS02125 (SPYALAB49_000437)	comA/nlmT	401726..403879 (-)	2154	WP_014635341.1	peptide cleavage/export ABC transporter	Regulator
SPYALAB49_RS09245	-	404331..405017 (+)	687	Protein_373	transposase	-
SPYALAB49_RS02140 (SPYALAB49_000439)	-	405205..405450 (+)	246	WP_002994504.1	Blp family class II bacteriocin	-
SPYALAB49_RS02145 (SPYALAB49_000440)	-	405465..405647 (+)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SPYALAB49_RS02150 (SPYALAB49_000441)	-	405838..406524 (-)	687	Protein_376	transposase	-
SPYALAB49_RS02155 (SPYALAB49_000442)	-	406842..407069 (+)	228	WP_012560514.1	Blp family class II bacteriocin	-
SPYALAB49_RS02160 (SPYALAB49_000443)	-	407082..407282 (+)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SPYALAB49_RS10040 (SPYALAB49_000444)	-	407643..407771 (+)	129	WP_002985724.1	hypothetical protein	-
SPYALAB49_RS02170	-	407821..408102 (+)	282	WP_011054252.1	hypothetical protein	-
SPYALAB49_RS02175	-	408296..408697 (+)	402	WP_023605036.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80533.41 Da
• Isoelectric Point: 7.0109

>NTDB_id=40381 SPYALAB49_RS02125 WP_014635341.1 401726..403879(-) (comA/nlmT) [Streptococcus pyogenes Alab49]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLASEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=40381 SPYALAB49_RS02125 WP_014635341.1 401726..403879(-) (comA/nlmT) [Streptococcus pyogenes Alab49]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCATCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.867	99.721	0.727
comA	Streptococcus mitis NCTC 12261	67.511	99.163	0.669
comA	Streptococcus mitis SK321	67.089	99.163	0.665
comA	Streptococcus pneumoniae Rx1	67.089	99.163	0.665
comA	Streptococcus pneumoniae D39	67.089	99.163	0.665
comA	Streptococcus pneumoniae R6	67.089	99.163	0.665
comA	Streptococcus pneumoniae TIGR4	66.807	99.163	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	66.014	99.721	0.658