Detailed information NTG0403706

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: GL187_RS09435
• Genome accession: NZ_CP046379
• Coordinates: 1853129..1854166 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727276.1
• Uniprot ID: A0AAQ2ZXI6
• Organism: Streptococcus pneumoniae strain 563
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1848129..1859166

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL187_RS09410 (GL187_09525)	-	1848868..1850199 (-)	1332	WP_016398203.1	hemolysin family protein	-
GL187_RS09415 (GL187_09530)	endA	1850490..1851314 (-)	825	WP_001036786.1	DNA-entry nuclease EndA	Machinery gene
GL187_RS09420 (GL187_09535)	-	1851353..1851541 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
GL187_RS09425 (GL187_09540)	murA	1851534..1852817 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
GL187_RS09430 (GL187_09545)	-	1852841..1853071 (-)	231	WP_000250392.1	DUF1146 family protein	-
GL187_RS09435 (GL187_09550)	sepM	1853129..1854166 (-)	1038	WP_000727276.1	SepM family pheromone-processing serine protease	Regulator
GL187_RS09440 (GL187_09555)	coaD	1854150..1854638 (-)	489	WP_001280742.1	pantetheine-phosphate adenylyltransferase	-
GL187_RS09445 (GL187_09560)	rsmD	1854628..1855167 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
GL187_RS09450 (GL187_09565)	asnA	1855232..1856224 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
GL187_RS09455 (GL187_09570)	-	1856336..1857019 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
GL187_RS09460 (GL187_09575)	-	1857075..1857815 (-)	741	WP_000152701.1	TrmH family RNA methyltransferase	-
GL187_RS09465 (GL187_09580)	-	1857849..1858127 (+)	279	WP_001174613.1	acylphosphatase	-
GL187_RS09470 (GL187_09585)	yidC	1858205..1859131 (+)	927	WP_000835948.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37553.61 Da
• Isoelectric Point: 5.0724

>NTDB_id=403706 GL187_RS09435 WP_000727276.1 1853129..1854166(-) (sepM) [Streptococcus pneumoniae strain 563]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHLDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=403706 GL187_RS09435 WP_000727276.1 1853129..1854166(-) (sepM) [Streptococcus pneumoniae strain 563]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCTGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.357	99.13	0.588