Detailed information NTG0402881

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: HVV27_RS08945
• Genome accession: NZ_CP055246
• Coordinates: 1799615..1802170 (-)
• Length: 851 a.a.
• NCBI ID: WP_011529121.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY767
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1794615..1807170

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HVV27_RS08900 (HVV27_08900)	-	1795001..1795648 (-)	648	WP_011529101.1	helix-turn-helix transcriptional regulator	-
HVV27_RS08905 (HVV27_08905)	-	1795814..1796011 (+)	198	WP_011529102.1	helix-turn-helix transcriptional regulator	-
HVV27_RS08910 (HVV27_08910)	-	1796025..1796639 (+)	615	WP_021299093.1	Bro-N domain-containing protein	-
HVV27_RS08915 (HVV27_08915)	-	1796666..1796902 (+)	237	Protein_1720	phage antirepressor protein	-
HVV27_RS08920 (HVV27_08920)	-	1797094..1797507 (+)	414	WP_012560493.1	DUF1492 domain-containing protein	-
HVV27_RS08925 (HVV27_08925)	-	1797582..1797782 (+)	201	WP_011529120.1	hypothetical protein	-
HVV27_RS08930 (HVV27_08930)	-	1797849..1798043 (+)	195	Protein_1723	DUF1492 domain-containing protein	-
HVV27_RS08935 (HVV27_08935)	-	1798018..1798401 (+)	384	WP_011285285.1	ArpU family phage packaging/lysis transcriptional regulator	-
HVV27_RS08940 (HVV27_08940)	-	1798602..1799219 (+)	618	WP_021340716.1	hypothetical protein	-
HVV27_RS08945 (HVV27_08945)	hexA	1799615..1802170 (-)	2556	WP_011529121.1	DNA mismatch repair protein MutS	Machinery gene
HVV27_RS09510 (HVV27_08950)	-	1802157..1802509 (-)	353	Protein_1727	YlbF family regulator	-
HVV27_RS08955 (HVV27_08955)	argR	1802506..1802943 (-)	438	WP_002982171.1	arginine repressor	-
HVV27_RS08960 (HVV27_08960)	argS	1803234..1804925 (+)	1692	WP_011529123.1	arginine--tRNA ligase	-
HVV27_RS08965 (HVV27_08965)	-	1805013..1805321 (+)	309	WP_012561077.1	bacteriocin immunity protein	-
HVV27_RS08970 (HVV27_08970)	-	1805348..1806220 (-)	873	WP_011529124.1	YitT family protein	-
HVV27_RS08975 (HVV27_08975)	-	1806263..1807141 (-)	879	WP_021299113.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95518.08 Da
• Isoelectric Point: 5.0199

>NTDB_id=402881 HVV27_RS08945 WP_011529121.1 1799615..1802170(-) (hexA) [Streptococcus pyogenes strain TSPY767]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAIDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSAYVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=402881 HVV27_RS08945 WP_011529121.1 1799615..1802170(-) (hexA) [Streptococcus pyogenes strain TSPY767]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTATTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTGTCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGTCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAAATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTCTAGATTTGGTAGAGAATGCTAG
AACGAATAAAAAACATGGGAGTCTGTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACAGATTTAAGCAATAGCTTAAAAGGTGTTTACGATATCGAACGCTTATCTAGCCGTGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCCATATTAGAGTCTTTTAACA
GCGCTTATGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTAAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGACCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATGTCAGTCCCTCCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAATATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.563	100	0.716
mutS	Pseudomonas stutzeri strain ATCC 17587	36.959	100	0.371