Detailed information NTG0402842

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: FOB92_RS08895
• Genome accession: NZ_CP046335
• Coordinates: 1848517..1849269 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866073.1
• Uniprot ID: A0A081S8D7
• Organism: Streptococcus mitis strain FDAARGOS_684
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1843517..1854269

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOB92_RS08875 (FOB92_08875)	-	1844962..1847604 (-)	2643	WP_000472064.1	YhgE/Pip domain-containing protein	-
FOB92_RS08880 (FOB92_08880)	-	1847732..1848274 (+)	543	WP_001158274.1	TetR/AcrR family transcriptional regulator	-
FOB92_RS08895 (FOB92_08895)	comE	1848517..1849269 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
FOB92_RS08900 (FOB92_08900)	comD	1849266..1850591 (-)	1326	WP_020902616.1	competence system sensor histidine kinase ComD	Regulator
FOB92_RS08905 (FOB92_08905)	comC	1850604..1850726 (-)	123	WP_004238992.1	competence-stimulating peptide ComC	Regulator
FOB92_RS08915 (FOB92_08915)	rlmH	1851009..1851488 (-)	480	WP_000695934.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FOB92_RS08920 (FOB92_08920)	htrA	1851671..1852852 (+)	1182	WP_000681587.1	S1C family serine protease	Regulator
FOB92_RS08925 (FOB92_08925)	spo0J	1852910..1853668 (+)	759	WP_000410370.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29947.32 Da
• Isoelectric Point: 6.9819

>NTDB_id=402842 FOB92_RS08895 WP_000866073.1 1848517..1849269(-) (comE) [Streptococcus mitis strain FDAARGOS_684]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=402842 FOB92_RS08895 WP_000866073.1 1848517..1849269(-) (comE) [Streptococcus mitis strain FDAARGOS_684]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAATTGAGAAAAAAGGGTTTGAAGTTGCTCAGTTTATTCGTCATCACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGTGTCTCTCATAAATTACGCATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081S8D7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus pneumoniae Rx1	98.4	100	0.984
comE	Streptococcus pneumoniae D39	98.4	100	0.984
comE	Streptococcus pneumoniae R6	98.4	100	0.984
comE	Streptococcus pneumoniae TIGR4	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	41.7	98.8	0.412