Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   FOB91_RS08640 Genome accession   NZ_CP046328
Coordinates   1777575..1778309 (+) Length   244 a.a.
NCBI ID   WP_011999888.1    Uniprot ID   A8AV82
Organism   Streptococcus gordonii strain FDAARGOS_683     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1762360..1784465 1777575..1778309 within 0


Gene organization within MGE regions


Location: 1762360..1784465
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOB91_RS08560 (FOB91_08560) - 1762360..1762878 (-) 519 WP_000181350.1 helix-turn-helix domain-containing protein -
  FOB91_RS08565 (FOB91_08565) - 1763026..1763307 (+) 282 WP_000005472.1 hypothetical protein -
  FOB91_RS08570 (FOB91_08570) - 1763316..1764155 (+) 840 WP_002914039.1 phage replisome organizer N-terminal domain-containing protein -
  FOB91_RS08575 (FOB91_08575) - 1764514..1764846 (+) 333 WP_001220782.1 hypothetical protein -
  FOB91_RS08580 (FOB91_08580) - 1764827..1765021 (+) 195 WP_000469564.1 hypothetical protein -
  FOB91_RS10860 - 1765482..1765859 (-) 378 Protein_1659 hypothetical protein -
  FOB91_RS10810 (FOB91_08585) - 1766111..1766284 (-) 174 WP_002914036.1 hypothetical protein -
  FOB91_RS08590 (FOB91_08590) - 1766313..1766927 (+) 615 WP_000615750.1 CadD family cadmium resistance transporter -
  FOB91_RS08595 (FOB91_08595) cadX 1766939..1767277 (+) 339 WP_011999882.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  FOB91_RS08600 (FOB91_08600) merR 1767547..1767939 (+) 393 WP_000640389.1 Hg(II)-responsive transcriptional regulator -
  FOB91_RS08605 (FOB91_08605) merA 1767968..1769863 (+) 1896 WP_011999883.1 mercury(II) reductase -
  FOB91_RS08610 (FOB91_08610) - 1770092..1771344 (+) 1253 Protein_1665 ISL3 family transposase -
  FOB91_RS08615 (FOB91_08615) - 1771934..1772812 (-) 879 WP_011999884.1 LysR family transcriptional regulator -
  FOB91_RS08620 (FOB91_08620) - 1772938..1773288 (-) 351 WP_011999885.1 helix-turn-helix domain-containing protein -
  FOB91_RS08625 (FOB91_08625) - 1773659..1775284 (+) 1626 WP_011999886.1 malolactic enzyme -
  FOB91_RS08630 (FOB91_08630) - 1775361..1776308 (+) 948 WP_011999887.1 AEC family transporter -
  FOB91_RS08635 (FOB91_08635) - 1776761..1776907 (-) 147 Protein_1670 site-specific integrase -
  FOB91_RS08640 (FOB91_08640) comE/blpR 1777575..1778309 (+) 735 WP_011999888.1 response regulator transcription factor Regulator
  FOB91_RS08645 (FOB91_08645) - 1778385..1779659 (+) 1275 WP_065428464.1 GHKL domain-containing protein -
  FOB91_RS08650 (FOB91_08650) - 1779934..1780614 (+) 681 WP_011999889.1 ATP-binding cassette domain-containing protein -
  FOB91_RS08655 (FOB91_08655) - 1780607..1781326 (+) 720 WP_041789519.1 ABC transporter permease -
  FOB91_RS08660 (FOB91_08660) - 1781678..1781881 (-) 204 WP_011999891.1 CsbD family protein -
  FOB91_RS08665 (FOB91_08665) - 1782063..1782692 (-) 630 WP_011999892.1 DUF421 domain-containing protein -
  FOB91_RS08670 (FOB91_08670) - 1782692..1783144 (-) 453 WP_011999893.1 DUF3290 family protein -
  FOB91_RS08675 (FOB91_08675) - 1783429..1783977 (+) 549 WP_011999894.1 DUF6609 family protein -

Sequence

Protein


Download         Length: 244 a.a.        Molecular weight: 28581.94 Da        Isoelectric Point: 6.6147

>NTDB_id=402709 FOB91_RS08640 WP_011999888.1 1777575..1778309(+) (comE/blpR) [Streptococcus gordonii strain FDAARGOS_683]
MLNIYVLEDELLQQSRIETIIYKVIKDENLKINKFEIFGKPSQLLAEISERGAHQLFFLDIEIKDEEKKGLELAYQIRKL
DPNATIVFVTTHSEFMPLTFRYKVSALDFIDKALGDLHFYERVKSAIEYTLEKNGSTVAHDSFKFETSLSRVQVPFNKIL
YFETSPTVHKVIMHTVDERLEFYAGISEIEKSDNRLYRCHKSFVVNPENISKIDKENRLILFENGESCLVSKTKLKKLKE
RLDF

Nucleotide


Download         Length: 735 bp        

>NTDB_id=402709 FOB91_RS08640 WP_011999888.1 1777575..1778309(+) (comE/blpR) [Streptococcus gordonii strain FDAARGOS_683]
ATGCTTAACATTTATGTTTTGGAAGACGAATTACTACAGCAGTCTCGCATAGAGACTATTATTTATAAGGTTATAAAAGA
TGAAAATTTAAAAATTAATAAGTTTGAGATTTTTGGAAAGCCATCTCAATTATTAGCAGAGATAAGTGAGAGAGGGGCTC
ATCAGTTATTTTTTTTAGATATTGAGATCAAGGATGAAGAAAAAAAAGGATTAGAGCTTGCTTATCAAATTAGAAAACTC
GATCCCAATGCAACTATTGTCTTTGTGACTACTCATTCTGAGTTTATGCCATTAACATTTAGATATAAAGTTAGTGCTTT
GGATTTTATTGATAAGGCACTTGGTGATCTTCATTTTTATGAAAGAGTAAAATCAGCGATTGAATATACATTGGAAAAAA
ATGGAAGTACTGTTGCTCATGATTCTTTTAAATTCGAAACATCACTATCTCGTGTTCAAGTTCCATTTAATAAAATTCTT
TATTTCGAAACATCGCCTACTGTGCATAAGGTTATTATGCATACGGTAGATGAAAGATTAGAATTTTATGCTGGAATTTC
TGAGATTGAAAAATCGGATAATAGGTTATACAGATGTCACAAGTCATTTGTCGTAAATCCTGAAAACATTAGTAAGATTG
ATAAGGAAAATAGGCTAATTCTATTTGAAAATGGAGAAAGTTGCTTAGTTTCTAAAACTAAATTAAAGAAACTCAAGGAA
AGGTTAGATTTTTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-118)

LytTr DNA-binding domain (LytTR)

(152-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AV82

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

56.198

99.18

0.557
  comE/comE1 Streptococcus equinus JB1

46.218

97.541

0.451
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.891

100

0.414
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.891

100

0.414
  comE/comE2 Streptococcus equinus JB1

38.683

99.59

0.385
  comE Streptococcus mitis NCTC 12261

37.903

100

0.385
  comE Streptococcus pneumoniae D39

37.903

100

0.385
  comE Streptococcus pneumoniae Rx1

37.903

100

0.385
  comE Streptococcus pneumoniae R6

37.903

100

0.385
  comE Streptococcus pneumoniae TIGR4

37.903

100

0.385
  comE Streptococcus mitis SK321

37.903

100

0.385
  comE Streptococcus infantis strain Atu-4

36.29

100

0.369

Multiple sequence alignment