Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   GKC13_RS07985 Genome accession   NZ_CP046134
Coordinates   1549598..1551115 (-) Length   505 a.a.
NCBI ID   WP_207559739.1    Uniprot ID   A0A3G6JL13
Organism   Streptococcus thermophilus strain MAG_rmk202_sterm     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1544598..1556115
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GKC13_RS07960 - 1544771..1545439 (-) 669 Protein_1575 HI_0552 family protein -
  GKC13_RS07965 (GKC13_08070) der 1545503..1546813 (-) 1311 WP_179970760.1 ribosome biogenesis GTPase Der -
  GKC13_RS07970 (GKC13_08075) dnaI 1546919..1547821 (-) 903 WP_002946786.1 primosomal protein DnaI -
  GKC13_RS07975 (GKC13_08080) - 1547825..1549000 (-) 1176 WP_002949643.1 DnaD domain protein -
  GKC13_RS07980 (GKC13_08085) nrdR 1548997..1549476 (-) 480 WP_002949642.1 transcriptional regulator NrdR -
  GKC13_RS07985 (GKC13_08090) covS 1549598..1551115 (-) 1518 WP_207559739.1 HAMP domain-containing histidine kinase Regulator
  GKC13_RS07990 (GKC13_08095) covR 1551112..1551801 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  GKC13_RS07995 (GKC13_08100) - 1551957..1552493 (-) 537 WP_002946488.1 YceD family protein -
  GKC13_RS08000 (GKC13_08105) rsmG 1552790..1553503 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  GKC13_RS08005 (GKC13_08110) - 1553573..1554937 (+) 1365 WP_269149496.1 potassium transporter TrkG -
  GKC13_RS08010 (GKC13_08115) - 1554977..1555648 (+) 672 WP_002946492.1 TrkA family potassium uptake protein -
  GKC13_RS10240 - 1555665..1555835 (-) 171 Protein_1586 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57557.99 Da        Isoelectric Point: 5.5179

>NTDB_id=401532 GKC13_RS07985 WP_207559739.1 1549598..1551115(-) (covS) [Streptococcus thermophilus strain MAG_rmk202_sterm]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSSEPLLAAFY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLKFYYALKERLIFLLIFLEVGMTVLVIAVIVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQVTIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=401532 GKC13_RS07985 WP_207559739.1 1549598..1551115(-) (covS) [Streptococcus thermophilus strain MAG_rmk202_sterm]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTTCAGAGCCGCTTTTAGCGGCCTTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGAAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAATTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACAATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTCCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGGTTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

ArlS sensor domain (ArlS_N)

(39-187)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3G6JL13

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.024

99.406

0.935

Multiple sequence alignment