Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   GKC13_RS06530 Genome accession   NZ_CP046134
Coordinates   1258280..1260538 (+) Length   752 a.a.
NCBI ID   WP_207559758.1    Uniprot ID   A0A3G6JY55
Organism   Streptococcus thermophilus strain MAG_rmk202_sterm     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1253280..1265538
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GKC13_RS06505 (GKC13_06570) - 1254424..1254900 (-) 477 WP_014608118.1 ferrous iron transport protein A -
  GKC13_RS06510 (GKC13_06575) - 1255074..1255808 (-) 735 WP_011225688.1 amino acid ABC transporter ATP-binding protein -
  GKC13_RS06515 (GKC13_06580) - 1255808..1256488 (-) 681 WP_180483520.1 amino acid ABC transporter permease -
  GKC13_RS06520 (GKC13_06585) - 1256760..1256990 (-) 231 WP_011225686.1 DUF1797 family protein -
  GKC13_RS06525 (GKC13_06590) argF 1257059..1258039 (-) 981 WP_014608116.1 ornithine carbamoyltransferase -
  GKC13_RS06530 (GKC13_06595) clpE 1258280..1260538 (+) 2259 WP_207559758.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  GKC13_RS06535 (GKC13_06600) - 1260681..1261139 (+) 459 WP_002947302.1 NUDIX hydrolase -
  GKC13_RS06540 (GKC13_06605) - 1261149..1261451 (+) 303 WP_014608115.1 DUF1827 family protein -
  GKC13_RS06545 (GKC13_06610) - 1261492..1262455 (-) 964 Protein_1297 Gfo/Idh/MocA family oxidoreductase -
  GKC13_RS06550 (GKC13_06615) - 1262554..1263789 (-) 1236 WP_014608114.1 aminoacyltransferase -
  GKC13_RS10540 (GKC13_06620) - 1263885..1264259 (-) 375 WP_232979548.1 VTT domain-containing protein -
  GKC13_RS10125 - 1264522..1264788 (-) 267 WP_080998415.1 DUF3862 domain-containing protein -
  GKC13_RS10130 - 1264746..1265144 (-) 399 WP_014608112.1 DUF3862 domain-containing protein -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83828.99 Da        Isoelectric Point: 5.1551

>NTDB_id=401522 GKC13_RS06530 WP_207559758.1 1258280..1260538(+) (clpE) [Streptococcus thermophilus strain MAG_rmk202_sterm]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIIKSDPENPLNQFNQAGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAA
ELSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPIGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEKAH
PDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSVINHLGDFFSPEFMNRFDGIIE
FSALSKENLLTIVDLMLDGVNQRLANNGIHLSVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKEHITIKSAKKTEKTSQKTEALKEVN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=401522 GKC13_RS06530 WP_207559758.1 1258280..1260538(+) (clpE) [Streptococcus thermophilus strain MAG_rmk202_sterm]
ATGCTCTGCCAAAACTGTAACCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATAAAATCTGATCCAGAGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAACTTCCGTTCTTCTAACGGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCAGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACCTCAAGGCCT
TCTCGAAGAATTTGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATCGTTGATGGAGATGTGCCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAAAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCAACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCTGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGTATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGCA
GAATTATCCAACCGCTACATTCAGGACCGTTTCTTGCCAGACAAGGCCATCGACCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATCGATCCTAAGGACCTCGATAAACGTTTGATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGCGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAAAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTATCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCCGCAG
TTGATAAGATTGCCAAAGCTATCCGCCGTAATCGTGTTGGACTTGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTAGGCCCTACAGGAGTCGGTAAAACTGAGCTCTCTAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACCGAAAAGGTCCGCCGTAACCCTTATTCACTCATTCTCCTTGATGAGGTTGAAAAAGCTCAC
CCAGATGTGCTTCACATGTTCCTTCAGGTACTTGACGATGGTCGTCTGACTGATGGTCAAGGGAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCAAGTGTAGGTTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTGTTATCAACCACCTTGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCTCTGCCCTAAGCAAGGAAAATCTCCTTACTATCGTGGACCTTATGCTTGATGGCGTCAACCAACGCTTGGCAAACAA
CGGTATCCACCTCAGTGTGACTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCACATCGAAGATGCCATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGGAACACATCACCATTAAATCTGCTAAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGTCAACTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-269)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)

AAA lid domain (AAA_lid_9)

(288-386)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3G6JY55

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.421

99.867

0.843
  clpE Streptococcus pneumoniae Rx1

82.048

100

0.82
  clpE Streptococcus pneumoniae D39

82.048

100

0.82
  clpE Streptococcus pneumoniae R6

82.048

100

0.82
  clpE Streptococcus pneumoniae TIGR4

81.915

100

0.819
  clpC Lactococcus lactis subsp. cremoris KW2

76.502

99.601

0.762
  clpC Bacillus subtilis subsp. subtilis str. 168

51.618

86.303

0.445
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.189

87.234

0.403
  clpC Streptococcus pneumoniae Rx1

46.984

83.777

0.394
  clpC Streptococcus pneumoniae D39

46.984

83.777

0.394
  clpC Streptococcus pneumoniae TIGR4

46.825

83.777

0.392
  clpC Streptococcus mutans UA159

46.326

83.245

0.386
  clpC Streptococcus thermophilus LMD-9

46.4

83.112

0.386
  clpC Streptococcus thermophilus LMG 18311

46.08

83.112

0.383

Multiple sequence alignment