Detailed information NTG0040052

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SGGBAA2069_RS05930
• Genome accession: NC_015215
• Coordinates: 1189237..1189911 (-)
• Length: 224 a.a.
• NCBI ID: WP_009854247.1
• Uniprot ID: A0A139MP14
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1184237..1194911

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGGBAA2069_RS05905 (SGGBAA2069_c11250)	deoC	1184665..1185327 (-)	663	WP_009854243.1	deoxyribose-phosphate aldolase	-
SGGBAA2069_RS05910 (SGGBAA2069_c11260)	-	1185818..1186411 (-)	594	WP_012961986.1	class I SAM-dependent methyltransferase	-
SGGBAA2069_RS05915 (SGGBAA2069_c11270)	coaA	1186525..1187445 (+)	921	WP_009854245.1	type I pantothenate kinase	-
SGGBAA2069_RS05920 (SGGBAA2069_c11280)	rpsT	1187520..1187771 (+)	252	WP_003064878.1	30S ribosomal protein S20	-
SGGBAA2069_RS05925 (SGGBAA2069_c11290)	ciaH	1187907..1189247 (-)	1341	WP_009854246.1	sensor histidine kinase	Regulator
SGGBAA2069_RS05930 (SGGBAA2069_c11300)	ciaR	1189237..1189911 (-)	675	WP_009854247.1	response regulator transcription factor	Regulator
SGGBAA2069_RS05935 (SGGBAA2069_c11310)	-	1190109..1192652 (-)	2544	WP_009854248.1	M1 family metallopeptidase	-
SGGBAA2069_RS05940 (SGGBAA2069_c11320)	phoU	1192875..1193528 (-)	654	WP_009854249.1	phosphate signaling complex protein PhoU	-
SGGBAA2069_RS05945 (SGGBAA2069_c11330)	pstB	1193559..1194317 (-)	759	WP_009854250.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25465.13 Da
• Isoelectric Point: 4.3102

>NTDB_id=40052 SGGBAA2069_RS05930 WP_009854247.1 1189237..1189911(-) (ciaR) [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKYNDNTLSYEELTVDTSTNTTIANGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFAKNLQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=40052 SGGBAA2069_RS05930 WP_009854247.1 1189237..1189911(-) (ciaR) [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGATTAAGATATTATTAGTAGAAGATGATTTGAGTCTATCTAATTCCATTTTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTATTTGACGGCGAAGAAGGTTTGTACGAAGCTGAAAGTGGCGTATATGACCTTATTTTGCTTGACTTGATGT
TACCTGAAAAAGATGGTTTCCAAGTGCTTAAAGAGTTACGAGAAAAAGGTGTGTCAACACCAGTACTTATTATGACTGCC
AAAGAAAGCCTTGATGATAAGGGACATGGTTTCGAGTTGGGAGCAGATGATTACCTTACTAAACCATTTTACCTTGAAGA
GCTAAAAATGCGTATTCAAGCTCTTTTAAAACGTTCGGGTAAATACAACGACAATACCTTATCTTATGAAGAATTAACCG
TTGACACTTCTACCAATACAACAATAGCTAACGGTAAAGAAGTCGAGCTGCTTGGTAAAGAATTTGATTTGTTGGTTTAT
TTCTTACAAAATCAAAATGTTATTTTACCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGATAGTGATACAACGAT
TTCGGTTGTTGAAGTTTACGTTTCAAAAATTCGAAAAAAACTCAAAGGCACTACCTTTGCCAAAAATCTTCAAACCCTAC
GGAGTGTAGGTTATATTCTGAAAAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A139MP14

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	92.825	99.554	0.924
ciaR	Streptococcus pneumoniae Rx1	87.054	100	0.871
ciaR	Streptococcus pneumoniae D39	87.054	100	0.871
ciaR	Streptococcus pneumoniae R6	87.054	100	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.054	100	0.871
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.938	100	0.393
vicR	Streptococcus mutans UA159	35.47	100	0.371
micA	Streptococcus pneumoniae Cp1015	35.622	100	0.371