Detailed information NTG0399367

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: GJE17_RS05865
• Genome accession: NZ_CP045930
• Coordinates: 1167529..1168566 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain AUSMDU00010539
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1162529..1173566

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GJE17_RS05845 (GJE17_05845)	-	1163271..1163897 (+)	627	WP_002983834.1	prepilin peptidase	-
GJE17_RS05850 (GJE17_05850)	rlmN	1163979..1165058 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
GJE17_RS05855 (GJE17_05855)	-	1165062..1165682 (-)	621	WP_002992791.1	YutD family protein	-
GJE17_RS05860 (GJE17_05860)	-	1166130..1167107 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
GJE17_RS05865 (GJE17_05865)	sepM	1167529..1168566 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
GJE17_RS05870 (GJE17_05870)	coaD	1168553..1169044 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
GJE17_RS05875 (GJE17_05875)	rsmD	1169034..1169573 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
GJE17_RS05880 (GJE17_05880)	asnA	1169696..1170688 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
GJE17_RS05885 (GJE17_05885)	arcC	1171001..1171951 (-)	951	WP_010922501.1	carbamate kinase	-
GJE17_RS05890 (GJE17_05890)	-	1171971..1173302 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=399367 GJE17_RS05865 WP_010922499.1 1167529..1168566(-) (sepM) [Streptococcus pyogenes strain AUSMDU00010539]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=399367 GJE17_RS05865 WP_010922499.1 1167529..1168566(-) (sepM) [Streptococcus pyogenes strain AUSMDU00010539]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693