Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | GJE17_RS05510 | Genome accession | NZ_CP045930 |
| Coordinates | 1093133..1094938 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain AUSMDU00010539 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1072903..1119972 | 1093133..1094938 | within | 0 |
Gene organization within MGE regions
Location: 1072903..1119972
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJE17_RS05430 (GJE17_05430) | - | 1072941..1074215 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| GJE17_RS05435 (GJE17_05435) | - | 1074310..1075737 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| GJE17_RS05440 (GJE17_05440) | ptsP | 1075922..1077655 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| GJE17_RS05445 (GJE17_05445) | - | 1077660..1077923 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| GJE17_RS05450 (GJE17_05450) | - | 1078316..1078534 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| GJE17_RS05455 (GJE17_05455) | nrdE | 1078554..1080713 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| GJE17_RS05460 (GJE17_05460) | nrdF | 1081046..1082005 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| GJE17_RS05465 (GJE17_05465) | - | 1082067..1083293 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| GJE17_RS05470 (GJE17_05470) | - | 1083389..1084546 (+) | 1158 | Protein_1023 | IS3 family transposase | - |
| GJE17_RS05475 (GJE17_05475) | - | 1084638..1085333 (-) | 696 | WP_031488553.1 | CPBP family intramembrane glutamic endopeptidase | - |
| GJE17_RS05480 (GJE17_05480) | - | 1085352..1086113 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| GJE17_RS05485 (GJE17_05485) | - | 1086110..1086325 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| GJE17_RS05490 (GJE17_05490) | alaS | 1086665..1089283 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| GJE17_RS05495 (GJE17_05495) | prsA | 1089670..1090725 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| GJE17_RS05500 (GJE17_05500) | - | 1090788..1091495 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| GJE17_RS05505 (GJE17_05505) | - | 1091561..1092757 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| GJE17_RS05510 (GJE17_05510) | pepF | 1093133..1094938 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| GJE17_RS05515 (GJE17_05515) | - | 1094951..1095913 (-) | 963 | WP_031488550.1 | competence protein CoiA | - |
| GJE17_RS05520 (GJE17_05520) | - | 1096209..1096925 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| GJE17_RS05525 (GJE17_05525) | nagB | 1097044..1097748 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| GJE17_RS05530 (GJE17_05530) | queA | 1097950..1098978 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| GJE17_RS05535 (GJE17_05535) | - | 1098985..1100205 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| GJE17_RS05540 (GJE17_05540) | - | 1100359..1100949 (-) | 591 | WP_154079612.1 | serine hydrolase | - |
| GJE17_RS08780 (GJE17_05545) | - | 1100946..1101173 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| GJE17_RS05550 (GJE17_05550) | - | 1101174..1101407 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| GJE17_RS05555 (GJE17_05555) | sodA | 1101574..1102179 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| GJE17_RS05560 (GJE17_05560) | holA | 1102276..1103316 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| GJE17_RS05565 (GJE17_05565) | - | 1103387..1105630 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| GJE17_RS05570 (GJE17_05570) | - | 1105611..1106273 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| GJE17_RS05575 (GJE17_05575) | - | 1106473..1107213 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| GJE17_RS05580 (GJE17_05580) | - | 1107331..1108107 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| GJE17_RS05585 (GJE17_05585) | - | 1108097..1108375 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| GJE17_RS05590 (GJE17_05590) | - | 1108399..1110399 (-) | 2001 | WP_031488545.1 | potassium transporter Kup | - |
| GJE17_RS05595 (GJE17_05595) | - | 1110526..1112145 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| GJE17_RS05600 (GJE17_05600) | - | 1112452..1113996 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| GJE17_RS05605 (GJE17_05605) | - | 1114244..1114939 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| GJE17_RS05610 (GJE17_05610) | - | 1115019..1116410 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| GJE17_RS05615 (GJE17_05615) | - | 1116601..1117647 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| GJE17_RS05620 (GJE17_05620) | recR | 1117748..1118344 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| GJE17_RS08915 (GJE17_05625) | - | 1118391..1118582 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| GJE17_RS05630 (GJE17_05630) | - | 1119141..1119920 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=399364 GJE17_RS05510 WP_011054652.1 1093133..1094938(-) (pepF) [Streptococcus pyogenes strain AUSMDU00010539]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=399364 GJE17_RS05510 WP_011054652.1 1093133..1094938(-) (pepF) [Streptococcus pyogenes strain AUSMDU00010539]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |