Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   HRE60_RS07670 Genome accession   NZ_CP054153
Coordinates   1720845..1722950 (-) Length   701 a.a.
NCBI ID   WP_181670650.1    Uniprot ID   -
Organism   Streptococcus salivarius strain DB-B5     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1715845..1727950
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HRE60_RS07635 (HRE60_07635) - 1716006..1716797 (-) 792 WP_002884270.1 phosphotransferase family protein -
  HRE60_RS07640 (HRE60_07640) pptB 1716855..1717892 (-) 1038 WP_181670645.1 ABC transporter permease Regulator
  HRE60_RS07645 (HRE60_07645) pptA 1717889..1718620 (-) 732 WP_181670646.1 ABC transporter ATP-binding protein Regulator
  HRE60_RS07650 (HRE60_07650) - 1718685..1719104 (+) 420 WP_181670647.1 HIT family protein -
  HRE60_RS07655 (HRE60_07655) - 1719101..1719400 (+) 300 WP_084871000.1 hypothetical protein -
  HRE60_RS07660 (HRE60_07660) - 1719487..1719942 (-) 456 WP_238799460.1 glutaredoxin domain-containing protein -
  HRE60_RS07665 (HRE60_07665) - 1719932..1720372 (-) 441 WP_238799464.1 excalibur calcium-binding domain-containing protein -
  HRE60_RS07670 (HRE60_07670) clpE 1720845..1722950 (-) 2106 WP_181670650.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  HRE60_RS07675 (HRE60_07675) - 1723688..1724779 (-) 1092 WP_181670651.1 nucleotidyltransferase -
  HRE60_RS07680 (HRE60_07680) - 1724786..1725526 (-) 741 WP_181670652.1 class I SAM-dependent methyltransferase -
  HRE60_RS07685 (HRE60_07685) rsfS 1725732..1726085 (-) 354 WP_096832635.1 ribosome silencing factor -
  HRE60_RS07690 (HRE60_07690) yqeK 1726108..1726698 (-) 591 WP_181670653.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
  HRE60_RS07695 (HRE60_07695) - 1726695..1727327 (-) 633 WP_002884372.1 nicotinate-nucleotide adenylyltransferase -
  HRE60_RS07700 (HRE60_07700) yhbY 1727435..1727752 (-) 318 WP_181670654.1 ribosome assembly RNA-binding protein YhbY -

Sequence

Protein


Download         Length: 701 a.a.        Molecular weight: 77347.30 Da        Isoelectric Point: 4.7735

>NTDB_id=397550 HRE60_RS07670 WP_181670650.1 1720845..1722950(-) (clpE) [Streptococcus salivarius strain DB-B5]
MNNNFNNMDDLFNQLMGNMGGYRSENRRYMINGREVTPEEFAIYRQTGQLPGNEGEAVNPTQHQGKGPKQDGILAKLGRN
LTEEAREGKLDPVIGRNKEIQEACEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEA
GTQYRGSFEENIQNLVNEVKEAGNIILFFDEIHQILGAGSTGDGQGSKGLADILKPALSRGELTVIGATTQDEYRNTILK
NAALARRFNEVKVNAPSAEDTFKILQGIRDLYEKHHNVILPDEVLKAAVDFSVQYIPQRSLPDKAIDLVDVTAAHLAAQH
PVTDVNAVEHEIEEEKAKQEAAAAKEDYEAALNAKVRIEELEKKIANHTADLKVTATVNDVAESVERMTGIPVSQMGATD
IERLKDMGHRLQTKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGTKDAIIRLDMS
EYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIVLLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVI
IATSNAGFGYEANLTEDADKPELMDRLKPYFRPEFLNRFNAVIEFSHLSKEDLSKIVDLMLVEVNKTLSKKDIDLAVSEA
AKEYMTEEGYDEVMGVRPLRRVVEQQIRDKVTDFHLDNLDAKHLEADMEDGVLVIKEKDAK

Nucleotide


Download         Length: 2106 bp        

>NTDB_id=397550 HRE60_RS07670 WP_181670650.1 1720845..1722950(-) (clpE) [Streptococcus salivarius strain DB-B5]
ATGAACAACAACTTTAACAATATGGACGATCTTTTCAATCAATTGATGGGTAACATGGGTGGTTACCGTTCAGAAAACCG
TCGCTACATGATTAACGGTCGTGAAGTGACACCTGAAGAATTTGCTATCTACCGTCAAACAGGTCAATTGCCTGGTAATG
AAGGTGAAGCAGTGAACCCAACTCAACATCAAGGTAAAGGACCTAAACAAGATGGTATCCTTGCTAAACTTGGTCGTAAC
TTGACTGAAGAAGCTCGCGAAGGTAAATTGGATCCTGTTATCGGACGTAACAAAGAAATCCAAGAAGCTTGCGAAATCTT
GGCTCGTCGTACCAAGAATAACCCAGTCCTTGTCGGGGACGCTGGGGTTGGTAAAACAGCCGTAGTTGAAGGTTTGGCTC
AAGCTATCGTTAATGGTGATGTCCCAGCTGCTATCAAGAACAAAGAAATCATCTCAATCGATATTTCTGGACTTGAAGCT
GGTACGCAATACCGTGGTAGCTTTGAAGAAAACATTCAAAACTTGGTAAATGAAGTCAAAGAAGCTGGAAATATTATCCT
CTTCTTCGATGAAATCCACCAAATTCTTGGTGCCGGAAGCACTGGCGATGGCCAAGGCTCTAAAGGTCTTGCTGATATCT
TGAAACCTGCTCTTTCACGTGGTGAATTGACAGTGATTGGTGCAACAACTCAAGATGAATACCGTAACACTATCTTGAAG
AACGCTGCTCTTGCTCGTCGTTTCAACGAAGTTAAGGTTAATGCTCCTTCTGCTGAAGATACCTTCAAGATTCTCCAAGG
TATCCGTGATCTTTATGAAAAACACCACAATGTTATCTTGCCAGATGAAGTTTTGAAAGCAGCAGTAGATTTCTCTGTAC
AATACATTCCACAACGTAGCTTGCCAGATAAGGCTATCGACCTTGTCGATGTAACAGCGGCTCACTTGGCTGCTCAACAC
CCAGTGACTGATGTGAATGCTGTTGAACATGAAATCGAAGAAGAAAAAGCTAAACAAGAAGCTGCAGCTGCTAAAGAAGA
TTATGAAGCAGCTCTAAATGCTAAAGTTCGCATTGAAGAACTTGAAAAGAAAATTGCTAACCACACAGCAGACCTTAAAG
TCACAGCAACTGTCAACGATGTGGCTGAATCTGTAGAACGTATGACTGGTATTCCAGTGTCACAAATGGGTGCAACTGAT
ATCGAACGTTTGAAAGATATGGGTCACCGTTTGCAAACTAAGGTTATCGGTCAAGATAAAGCCGTTGAAGCAGTGGCACG
TGCCATCCGTCGTAACCGTGCAGGATTTGACGAAGGTAACCGTCCAATTGGTAGCTTCCTCTTTGTAGGACCTACTGGTG
TTGGTAAAACTGAGTTGGCTAAACAATTGGCTCTTGATATGTTCGGAACTAAAGATGCTATCATCCGTTTGGACATGTCA
GAATACAGTGACCGCACAGCCGTTTCTAAATTGATTGGTACAACAGCTGGTTATGTTGGTTATGATGACAATAGCAATAC
TTTGACAGAACGTGTTCGTCGTAACCCATACTCAATCGTCCTTCTCGACGAAATTGAAAAGGCTGACCCTCAAGTTATCA
CACTTCTTCTCCAAGTTTTGGATGATGGTCGTTTGACAGATGGTCAAGGTAACACTGTAAACTTCAAGAATACTGTGATT
ATCGCAACTTCAAACGCAGGTTTTGGCTATGAAGCTAACTTGACAGAAGATGCTGATAAACCAGAACTTATGGATCGTTT
GAAACCTTACTTCCGTCCAGAATTCCTTAACCGTTTCAATGCTGTCATCGAATTCTCACACTTGAGCAAAGAAGATCTTT
CTAAGATCGTAGACCTTATGTTGGTTGAAGTTAACAAGACGCTTTCTAAGAAAGACATTGACTTGGCAGTTAGCGAAGCT
GCTAAAGAATACATGACTGAAGAAGGCTACGATGAAGTCATGGGTGTTCGTCCACTCCGTCGTGTGGTTGAACAACAAAT
CCGTGACAAAGTCACAGACTTCCACTTGGATAACCTTGATGCTAAACACCTAGAAGCTGATATGGAAGATGGTGTCTTGG
TTATCAAAGAAAAAGATGCTAAATAA

Domains

Predicted by InterProScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(608-678)

AAA lid domain (AAA_lid_9)

(257-351)

ATPase family associated with various cellular activities (AAA) (AAA)

(116-248)

AAA domain (Cdc48 subfamily) (AAA_2)

(441-601)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

46.79

100

0.468
  clpC Lactococcus lactis subsp. cremoris KW2

49.155

92.867

0.456
  clpE Streptococcus pneumoniae D39

48.678

91.726

0.447
  clpE Streptococcus pneumoniae R6

48.678

91.726

0.447
  clpE Streptococcus pneumoniae TIGR4

48.678

91.726

0.447
  clpE Streptococcus pneumoniae Rx1

48.678

91.726

0.447
  clpC Bacillus subtilis subsp. subtilis str. 168

45.511

92.154

0.419
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

42.089

92.867

0.391
  clpC Streptococcus pneumoniae TIGR4

43.248

88.73

0.384
  clpC Streptococcus pneumoniae Rx1

43.248

88.73

0.384
  clpC Streptococcus pneumoniae D39

43.248

88.73

0.384
  clpC Streptococcus thermophilus LMD-9

43.436

88.017

0.382
  clpC Streptococcus thermophilus LMG 18311

42.973

88.302

0.379
  clpC Streptococcus mutans UA159

42.332

89.301

0.378

Multiple sequence alignment