Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   GFB63_RS07645 Genome accession   NZ_CP045596
Coordinates   1488935..1491193 (-) Length   752 a.a.
NCBI ID   WP_084828592.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain TK-P3A     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1483935..1496193
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GFB63_RS07615 (GFB63_07825) - 1484333..1484953 (+) 621 WP_014621341.1 DUF3862 domain-containing protein -
  GFB63_RS07620 (GFB63_07830) - 1485166..1485708 (+) 543 WP_014621342.1 TVP38/TMEM64 family protein -
  GFB63_RS07625 (GFB63_07835) - 1485686..1486921 (+) 1236 WP_084825857.1 aminoacyltransferase -
  GFB63_RS07630 (GFB63_07840) - 1487020..1487981 (+) 962 Protein_1463 Gfo/Idh/MocA family protein -
  GFB63_RS07635 (GFB63_07845) - 1488022..1488324 (-) 303 WP_084825858.1 DUF1827 family protein -
  GFB63_RS07640 (GFB63_07850) - 1488334..1488792 (-) 459 WP_002950198.1 NUDIX hydrolase -
  GFB63_RS07645 (GFB63_07855) clpE 1488935..1491193 (-) 2259 WP_084828592.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  GFB63_RS07650 (GFB63_07860) argF 1491434..1492414 (+) 981 WP_100262187.1 ornithine carbamoyltransferase -
  GFB63_RS07655 (GFB63_07865) - 1492483..1492713 (+) 231 WP_011225686.1 DUF1797 family protein -
  GFB63_RS07660 (GFB63_07870) - 1492983..1493663 (+) 681 WP_014608117.1 amino acid ABC transporter permease -
  GFB63_RS07665 (GFB63_07875) - 1493663..1494397 (+) 735 WP_179972785.1 amino acid ABC transporter ATP-binding protein -
  GFB63_RS07670 (GFB63_07880) - 1494571..1495047 (+) 477 WP_193838221.1 ferrous iron transport protein A -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83788.94 Da        Isoelectric Point: 5.1506

>NTDB_id=395491 GFB63_RS07645 WP_084828592.1 1488935..1491193(-) (clpE) [Streptococcus thermophilus strain TK-P3A]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIMKSDPENPLNQFNQAGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAA
ELSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPIGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEKAH
PDVLHMFLQILDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSVINHLGDFFSPEFMNRFDGIIE
FSALSKENLLTIVDLMLDGVNQRLANNGIHLSVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKGHITIKSAQKTEKTSQKTEALKEVN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=395491 GFB63_RS07645 WP_084828592.1 1488935..1491193(-) (clpE) [Streptococcus thermophilus strain TK-P3A]
ATGCTCTGCCAAAACTGTAACCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATGAAATCTGATCCAGAGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAACTTCCGTTCTTCTAACGGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCAGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACCTCAAGGCCT
TCTCGAAGAATTTGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATCGTTGATGGAGATGTGCCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAAAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCAACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCTGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGTATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGCA
GAATTATCCAACCGCTACATTCAGGACCGTTTCTTGCCAGACAAGGCCATCGATCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATCGATCCTAAGGACCTCGATAAACGTTTGATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGTGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAAAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTATCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCCGCAG
TTGATAAGATTGCCAAAGCTATCCGCCGTAATCGTGTTGGACTTGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTAGGCCCTACAGGAGTCGGTAAAACTGAACTCTCCAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACTGAAAAGGTCCGCCGTAACCCTTATTCACTCATTCTCCTTGATGAGGTTGAAAAAGCTCAC
CCAGATGTGCTTCACATGTTCCTTCAGATACTTGATGATGGTCGTCTGACTGATGGTCAAGGGAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCAAGTGTAGGTTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTGTTATCAACCACCTCGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCTCTGCCCTAAGCAAGGAAAATCTCCTTACTATCGTGGACCTTATGCTTGATGGCGTCAACCAACGCTTGGCAAACAA
CGGTATCCACCTCAGTGTAACTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCACATCGAAGATGCCATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGGGACACATCACCATTAAATCTGCTCAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGTCAACTAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(288-386)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-269)

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.554

99.867

0.844
  clpE Streptococcus pneumoniae Rx1

81.782

100

0.818
  clpE Streptococcus pneumoniae D39

81.782

100

0.818
  clpE Streptococcus pneumoniae R6

81.782

100

0.818
  clpE Streptococcus pneumoniae TIGR4

81.649

100

0.816
  clpC Lactococcus lactis subsp. cremoris KW2

76.903

99.601

0.766
  clpC Bacillus subtilis subsp. subtilis str. 168

51.618

86.303

0.445
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.189

87.234

0.403
  clpC Streptococcus pneumoniae TIGR4

46.248

86.835

0.402
  clpC Streptococcus pneumoniae Rx1

46.825

83.777

0.392
  clpC Streptococcus pneumoniae D39

46.825

83.777

0.392
  clpC Streptococcus thermophilus LMD-9

46.24

83.112

0.384
  clpC Streptococcus mutans UA159

46.166

83.245

0.384
  clpC Streptococcus thermophilus LMG 18311

45.92

83.112

0.382

Multiple sequence alignment