Detailed information NTG0394119

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SA08028_RS10385
• Genome accession: NZ_CP045435
• Coordinates: 2070638..2071681 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 08-028
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2065638..2076681

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SA08028_RS10355 (SA08028_03091)	-	2066066..2067322 (-)	1257	WP_001793428.1	aminopeptidase	-
SA08028_RS10360	-	2067325..2067525 (-)	201	WP_000180460.1	DUF1128 family protein	-
SA08028_RS10365 (SA08028_01594)	-	2067672..2068136 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SA08028_RS10370 (SA08028_01595)	-	2068143..2068418 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SA08028_RS10375 (SA08028_01596)	-	2068696..2069907 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
SA08028_RS10380 (SA08028_01597)	vraR	2070019..2070648 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SA08028_RS10385 (SA08028_01598)	vraS	2070638..2071681 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SA08028_RS10390 (SA08028_01599)	liaF	2071678..2072379 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SA08028_RS10395 (SA08028_03093)	-	2072394..2072780 (-)	387	WP_001110179.1	hypothetical protein	-
SA08028_RS10400 (SA08028_01601)	map	2072997..2073755 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SA08028_RS10405 (SA08028_01602)	-	2074284..2075270 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SA08028_RS10410 (SA08028_01604)	-	2075759..2076172 (-)	414	WP_001837236.1	hypothetical protein	-
SA08028_RS10415	-	2076201..2076312 (-)	112	Protein_2031	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=394119 SA08028_RS10385 WP_001017131.1 2070638..2071681(-) (vraS) [Staphylococcus aureus strain 08-028]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=394119 SA08028_RS10385 WP_001017131.1 2070638..2071681(-) (vraS) [Staphylococcus aureus strain 08-028]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1