Detailed information NTG0392513

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D5R78_RS05175
• Genome accession: NZ_CP045187
• Coordinates: 1078916..1079962 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain VB19458
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1073916..1084962

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D5R78_RS05150 (D5R78_009430)	map	1074776..1075528 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
D5R78_RS05155 (D5R78_009425)	-	1075653..1076510 (-)	858	WP_011275370.1	SDR family oxidoreductase	-
D5R78_RS05160 (D5R78_009420)	-	1076582..1077594 (-)	1013	Protein_1040	HoxN/HupN/NixA family nickel/cobalt transporter	-
D5R78_RS05165 (D5R78_009415)	-	1077807..1078193 (+)	387	WP_011275373.1	hypothetical protein	-
D5R78_RS05170 (D5R78_009410)	liaF	1078218..1078919 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
D5R78_RS05175 (D5R78_009405)	vraS	1078916..1079962 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
D5R78_RS05180 (D5R78_009400)	vraR	1079952..1080581 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
D5R78_RS05185 (D5R78_009395)	-	1080645..1081856 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
D5R78_RS05190 (D5R78_009390)	-	1082053..1082337 (-)	285	WP_011275378.1	YtxH domain-containing protein	-
D5R78_RS05195 (D5R78_009385)	-	1082343..1082807 (-)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
D5R78_RS05200 (D5R78_009380)	-	1082949..1083158 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
D5R78_RS05205 (D5R78_009375)	-	1083172..1084419 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=392513 D5R78_RS05175 WP_011275375.1 1078916..1079962(+) (vraS) [Staphylococcus haemolyticus strain VB19458]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=392513 D5R78_RS05175 WP_011275375.1 1078916..1079962(+) (vraS) [Staphylococcus haemolyticus strain VB19458]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914