Detailed information NTG0392246

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GA597_RS05380
• Genome accession: NZ_CP045137
• Coordinates: 1078740..1079786 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain VB5326
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1073740..1084786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GA597_RS05355 (GA597_11440)	map	1074600..1075352 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
GA597_RS05360 (GA597_11435)	-	1075477..1076334 (-)	858	WP_011275370.1	SDR family oxidoreductase	-
GA597_RS05365 (GA597_11430)	-	1076406..1077418 (-)	1013	Protein_1060	HoxN/HupN/NixA family nickel/cobalt transporter	-
GA597_RS05370 (GA597_11425)	-	1077631..1078017 (+)	387	WP_011275373.1	hypothetical protein	-
GA597_RS05375 (GA597_11420)	liaF	1078042..1078743 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
GA597_RS05380 (GA597_11415)	vraS	1078740..1079786 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
GA597_RS05385 (GA597_11410)	vraR	1079776..1080405 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
GA597_RS05390 (GA597_11405)	-	1080469..1081680 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
GA597_RS05395 (GA597_11400)	-	1081877..1082161 (-)	285	WP_011275378.1	YtxH domain-containing protein	-
GA597_RS05400 (GA597_11395)	-	1082167..1082631 (-)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
GA597_RS05405 (GA597_11390)	-	1082773..1082982 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
GA597_RS05410 (GA597_11385)	-	1082996..1084243 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=392246 GA597_RS05380 WP_011275375.1 1078740..1079786(+) (vraS) [Staphylococcus haemolyticus strain VB5326]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=392246 GA597_RS05380 WP_011275375.1 1078740..1079786(+) (vraS) [Staphylococcus haemolyticus strain VB5326]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914