Detailed information NTG0389939

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: HLB22_RS13235
• Genome accession: NZ_CP053101
• Coordinates: 2655456..2657573 (+)
• Length: 705 a.a.
• NCBI ID: WP_001670193.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain EDCC5398
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2650456..2662573

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HLB22_RS13210 (HLB22_13220)	-	2650527..2650745 (+)	219	WP_000011687.1	sterile alpha motif-like domain-containing protein	-
HLB22_RS13215 (HLB22_13225)	-	2651134..2651565 (+)	432	WP_000455858.1	CHAP domain-containing protein	-
HLB22_RS13220 (HLB22_13230)	-	2651704..2652981 (-)	1278	WP_001180327.1	hydroxymethylglutaryl-CoA reductase, degradative	-
HLB22_RS13225 (HLB22_13235)	-	2653235..2654401 (+)	1167	WP_000151986.1	hydroxymethylglutaryl-CoA synthase	-
HLB22_RS13230 (HLB22_13240)	-	2654572..2655093 (-)	522	WP_000262592.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
HLB22_RS13235 (HLB22_13245)	clpE	2655456..2657573 (+)	2118	WP_001670193.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
HLB22_RS13240 (HLB22_13250)	-	2657640..2657810 (-)	171	WP_000111116.1	FeoB-associated Cys-rich membrane protein	-
HLB22_RS13245 (HLB22_13255)	feoB	2657823..2659817 (-)	1995	WP_000432895.1	ferrous iron transport protein B	-
HLB22_RS13250 (HLB22_13260)	-	2659829..2660056 (-)	228	WP_000932073.1	ferrous iron transport protein A	-

Sequence

Protein

• Length: 705 a.a.
• Molecular weight: 78383.79 Da
• Isoelectric Point: 4.6408

>NTDB_id=389939 HLB22_RS13235 WP_001670193.1 2655456..2657573(+) (clpE) [Staphylococcus aureus strain EDCC5398]
MNNNFFNSDFDSILRRMMQDMQSSNQTSNKKYYINGKEVSPEELAQFTQQGGNHSAEQSAQAFQQAALRQQGQQGQQGGN
GNYLEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEI
ISIDISSLEAGTQYRGAFEENIQKLVEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATT
QDEYRNNILKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFEEHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLD
ITAAHLSAQSPAIDKVATEKRISELEHDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTG
IPVSQMDDNDIERLKNISNRLRSKIIGQDQAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGN
KDALIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQG
NVINFKNTIIICTSNAGFGNGTDQEYDDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGIT
MNVSQDAKDWLIEEGYDEDLGARPLRRIVEQQVRDKITDYYLDHTDVKHVDLDIEDNELVVKGKS

Nucleotide

• Length: 2118 bp

>NTDB_id=389939 HLB22_RS13235 WP_001670193.1 2655456..2657573(+) (clpE) [Staphylococcus aureus strain EDCC5398]
ATGAATAACAATTTTTTCAATAGTGACTTCGATTCTATTTTACGAAGAATGATGCAAGACATGCAAAGCTCAAATCAGAC
TAGTAACAAGAAATACTATATTAATGGTAAAGAAGTTTCACCGGAAGAATTAGCACAATTTACGCAACAGGGTGGTAATC
ATTCTGCCGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACTAAGACAACAAGGTCAACAAGGTCAACAAGGTGGCAAT
GGCAATTATTTAGAACAAATTGGTCGCAATCTTACGCAAGAGGCTCGTGACGGATTATTAGATCCAGTCATCGGTCGTGA
TAAAGAAATCCAAGAGACTGCAGAAGTCTTAAGTAGACGCACTAAAAACAATCCTATCCTAGTCGGAGAAGCTGGGGTTG
GTAAAACTGCGATTGTCGAAGGTTTAGCGCAAGCAATCGTTGAAGGGAACGTACCTGCAGCAATCAAAGATAAAGAAATT
ATATCTATAGATATTTCATCGCTTGAAGCTGGAACGCAATATCGTGGCGCCTTTGAAGAAAACATCCAAAAGTTAGTTGA
AGGCGTTAAATCATCACAAAATGCTGTGCTCTTCTTTGACGAAATTCACCAAATCATCGGTTCCGGTGCAACTGGAAGTG
ATTCCGGTAGTAAAGGGTTATCTGATATTTTAAAACCAGCATTAAGTCGTGGTGAAATTTCAATTATAGGTGCAACGACT
CAAGATGAATATCGAAACAATATTCTTAAAGATGCTGCATTAACGCGCAGATTTAATGAAGTACTTGTTAATGAACCAAG
TGCTAAAGATACTGTTGAAATTTTAAAAGGTATTCGCGAAAAATTCGAAGAACACCATCAAGTAAAATTACCAGATGACG
TATTAAAAGCATGTGTTGACTTATCAATTCAATATATTCCACAACGATTATTACCAGATAAAGCAATCGATGTGTTAGAT
ATTACAGCAGCACATTTATCTGCACAAAGCCCTGCTATTGATAAAGTCGCGACTGAAAAACGTATTTCTGAATTGGAACA
TGATAAGCGTAAAGCGGTAAGTGCTGAAGAATATAAAAAAGCTGACGACATTCAAAATGAAATCAAATCATTACAAGATA
AATTAGAAAATAGTAATGGTGAACATACTGCCGTTGCTACTGTTCATGATATTTCAGATACTATTCAACGATTAACTGGT
ATTCCAGTTTCTCAAATGGATGATAACGATATTGAACGTTTAAAAAATATTTCTAATCGTTTAAGAAGTAAAATCATAGG
TCAAGATCAAGCTGTAGAAATGGTTTCTCGTGCAATTCGCCGTAATCGTGCTGGGTTTGATGACGGCAACCGTCCAATTG
GCAGTTTCCTATTTGTTGGCCCTACTGGTGTTGGTAAAACAGAGCTTGCTAAACAATTAGCAATTGATCTATTTGGTAAT
AAAGATGCACTGATTCGACTTGATATGAGTGAATATAGTGACACAACAGCTGTTTCAAAAATGATTGGTACAACTGCTGG
TTATGTCGGTTATGATGACAATTCAAATACGTTAACTGAAAAAGTACGCCGTAATCCATATTCAGTCATTCTATTTGATG
AAATCGAAAAAGCAAATCCACAAATTTTAACATTGTTATTACAAGTAATGGATGATGGTAATTTGACTGATGGTCAAGGT
AATGTCATCAACTTTAAAAATACAATTATTATTTGTACATCAAATGCTGGCTTTGGTAACGGTACAGACCAAGAATACGA
TGACATTATGCATGAAATGAAAAAATTCTTCCGCCCTGAATTCCTTAACCGCTTCAACGGTATCGTTGAATTCTTACATT
TAGATAAAGATGCATTACAAGATATCGTCAACTTATTATTAGACGATGTCCAAGTAACATTAGATAAAAAAGGTATTACG
ATGAATGTCTCTCAAGATGCAAAAGATTGGTTAATTGAAGAAGGTTATGATGAAGACTTAGGCGCACGCCCATTAAGACG
TATTGTTGAACAGCAAGTACGTGACAAAATTACAGATTACTATTTAGATCATACTGACGTTAAACATGTGGATTTAGATA
TCGAGGACAATGAATTAGTCGTCAAAGGTAAATCATGA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (451-606)

• AAA lid domain (AAA_lid_9) (267-366)

• ATPase family associated with various cellular activities (AAA) (AAA) (126-260)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (614-685)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	48.287	91.064	0.44
clpC	Lactococcus lactis subsp. cremoris KW2	44.932	93.759	0.421
clpE	Streptococcus pneumoniae Rx1	47.812	87.518	0.418
clpE	Streptococcus pneumoniae TIGR4	47.812	87.518	0.418
clpE	Streptococcus pneumoniae R6	47.812	87.518	0.418
clpE	Streptococcus pneumoniae D39	47.812	87.518	0.418
clpC	Bacillus subtilis subsp. subtilis str. 168	43.951	92.624	0.407
clpC	Streptococcus thermophilus LMD-9	44.48	88.652	0.394
clpC	Streptococcus thermophilus LMG 18311	44.32	88.652	0.393
clpC	Streptococcus pneumoniae TIGR4	43.942	87.801	0.386
clpC	Streptococcus pneumoniae Rx1	43.942	87.801	0.386
clpC	Streptococcus pneumoniae D39	43.942	87.801	0.386
clpC	Streptococcus mutans UA159	43.577	87.234	0.38
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.14	92.057	0.379