Detailed information NTG0389587

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HK402_RS10120
• Genome accession: NZ_CP053075
• Coordinates: 2024101..2025144 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: Q99SZ7
• Organism: Staphylococcus aureus strain SA01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2019101..2030144

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HK402_RS10090 (HK402_10100)	-	2019522..2020778 (-)	1257	WP_001795108.1	aminopeptidase	-
HK402_RS10095 (HK402_10105)	-	2020781..2020981 (-)	201	WP_000180460.1	DUF1128 family protein	-
HK402_RS10100 (HK402_10110)	-	2021128..2021592 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HK402_RS10105 (HK402_10115)	-	2021599..2021874 (+)	276	WP_170172378.1	YtxH domain-containing protein	-
HK402_RS10110 (HK402_10120)	-	2022152..2023369 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HK402_RS10115 (HK402_10125)	vraR	2023482..2024111 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HK402_RS10120 (HK402_10130)	vraS	2024101..2025144 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HK402_RS10125 (HK402_10135)	liaF	2025141..2025842 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HK402_RS10130 (HK402_10140)	-	2025857..2026243 (-)	387	WP_001110179.1	hypothetical protein	-
HK402_RS10135 (HK402_10145)	map	2026460..2027218 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HK402_RS10140 (HK402_10150)	-	2027749..2028735 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
HK402_RS10145 (HK402_10155)	-	2029166..2029579 (-)	414	WP_001557448.1	hypothetical protein	-
HK402_RS10150 (HK402_10160)	-	2029608..2029718 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=389587 HK402_RS10120 WP_001017131.1 2024101..2025144(-) (vraS) [Staphylococcus aureus strain SA01]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=389587 HK402_RS10120 WP_001017131.1 2024101..2025144(-) (vraS) [Staphylococcus aureus strain SA01]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: Q99SZ7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1