Detailed information NTG0387766

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FOB76_RS07420
• Genome accession: NZ_CP044093
• Coordinates: 1428199..1429236 (+)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain FDAARGOS_668
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1423199..1434236

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOB76_RS07395 (FOB76_07395)	-	1423462..1424793 (+)	1332	WP_002989063.1	dipeptidase	-
FOB76_RS07400 (FOB76_07400)	arcC	1424813..1425763 (+)	951	WP_002989065.1	carbamate kinase	-
FOB76_RS07405 (FOB76_07405)	asnA	1426077..1427069 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
FOB76_RS07410 (FOB76_07410)	rsmD	1427192..1427731 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FOB76_RS07415 (FOB76_07415)	coaD	1427721..1428212 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
FOB76_RS07420 (FOB76_07420)	sepM	1428199..1429236 (+)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
FOB76_RS07425 (FOB76_07425)	-	1429641..1430618 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
FOB76_RS07430 (FOB76_07430)	-	1431066..1431686 (+)	621	WP_032461520.1	YutD family protein	-
FOB76_RS07435 (FOB76_07435)	rlmN	1431690..1432769 (+)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FOB76_RS07440 (FOB76_07440)	-	1432851..1433477 (-)	627	WP_002989076.1	A24 family peptidase	-
FOB76_RS07445 (FOB76_07445)	-	1433705..1434232 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=387766 FOB76_RS07420 WP_002989068.1 1428199..1429236(+) (sepM) [Streptococcus pyogenes strain FDAARGOS_668]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=387766 FOB76_RS07420 WP_002989068.1 1428199..1429236(+) (sepM) [Streptococcus pyogenes strain FDAARGOS_668]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69