Detailed information NTG0386221

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: F1613_RS10790
• Genome accession: NZ_CP043845
• Coordinates: 2215517..2216563 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain ATCC 12228
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2210517..2221563

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F1613_RS10760 (F1613_10770)	-	2210901..2212142 (-)	1242	WP_001832467.1	aminopeptidase	-
F1613_RS10765 (F1613_10775)	-	2212144..2212359 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
F1613_RS10770 (F1613_10780)	-	2212500..2212964 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
F1613_RS10775 (F1613_10785)	-	2212972..2213256 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
F1613_RS10780 (F1613_10790)	-	2213663..2214841 (+)	1179	WP_002485151.1	YihY/virulence factor BrkB family protein	-
F1613_RS10785 (F1613_10795)	vraR	2214898..2215527 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
F1613_RS10790 (F1613_10800)	vraS	2215517..2216563 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
F1613_RS10795 (F1613_10805)	liaF	2216560..2217261 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
F1613_RS10800 (F1613_10810)	-	2217276..2217662 (-)	387	WP_001830382.1	hypothetical protein	-
F1613_RS10805 (F1613_10815)	map	2217820..2218575 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
F1613_RS10810 (F1613_10820)	-	2218749..2219735 (+)	987	WP_011082745.1	FUSC family protein	-
F1613_RS10815 (F1613_10825)	isaB	2219886..2220422 (-)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=386221 F1613_RS10790 WP_001830374.1 2215517..2216563(-) (vraS) [Staphylococcus epidermidis strain ATCC 12228]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=386221 F1613_RS10790 WP_001830374.1 2215517..2216563(-) (vraS) [Staphylococcus epidermidis strain ATCC 12228]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92