Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   MGAS2221_RS08250 Genome accession   NZ_CP043530
Coordinates   1620661..1621422 (-) Length   253 a.a.
NCBI ID   WP_002986029.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS2221     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1615661..1626422
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS2221_RS08230 (MGAS2221_1643) - 1615979..1617205 (-) 1227 WP_010921888.1 cysteine desulfurase -
  MGAS2221_RS08235 (MGAS2221_1644) sufD 1617236..1618498 (-) 1263 WP_010921887.1 Fe-S cluster assembly protein SufD -
  MGAS2221_RS08240 (MGAS2221_1645) sufC 1618593..1619363 (-) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  MGAS2221_RS08245 (MGAS2221_1646) - 1619485..1620654 (-) 1170 WP_002991122.1 MraY family glycosyltransferase -
  MGAS2221_RS08250 (MGAS2221_1647) mecA 1620661..1621422 (-) 762 WP_002986029.1 adaptor protein MecA Regulator
  MGAS2221_RS08255 (MGAS2221_1648) - 1621568..1622407 (-) 840 WP_002986031.1 undecaprenyl-diphosphate phosphatase -
  MGAS2221_RS08260 (MGAS2221_1649) - 1622473..1624371 (-) 1899 WP_010921886.1 DUF2207 domain-containing protein -
  MGAS2221_RS08265 (MGAS2221_1650) - 1624569..1626137 (+) 1569 WP_011285384.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1622

>NTDB_id=384864 MGAS2221_RS08250 WP_002986029.1 1620661..1621422(-) (mecA) [Streptococcus pyogenes strain MGAS2221]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=384864 MGAS2221_RS08250 WP_002986029.1 1620661..1621422(-) (mecA) [Streptococcus pyogenes strain MGAS2221]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAACGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment