Detailed information NTG0384483

Bioinformatically predicted

Overview

• Name: pepF
• Type: Regulator
• Locus tag: FZP47_RS11105
• Genome accession: NZ_CP043484
• Coordinates: 2246590..2248398 (-)
• Length: 602 a.a.
• NCBI ID: WP_002315655.1
• Uniprot ID: A0AB74CUB9
• Organism: Enterococcus faecium strain DMEA02
• Function: degradation of XIP; competence shut-off (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	2235560..2251655	2246590..2248398	within	0

Gene organization within MGE regions

Location: 2235560..2251655

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FZP47_RS11050 (FZP47_11050)	-	2235560..2238130 (-)	2571	WP_002335458.1	ATP-dependent RecD-like DNA helicase	-
FZP47_RS11055 (FZP47_11055)	-	2238150..2238809 (-)	660	WP_002328917.1	histidine phosphatase family protein	-
FZP47_RS11060 (FZP47_11060)	trmL	2238858..2239361 (-)	504	WP_002328916.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
FZP47_RS11065 (FZP47_11065)	-	2239582..2240448 (-)	867	WP_002328915.1	methyltransferase domain-containing protein	-
FZP47_RS11070 (FZP47_11070)	-	2240557..2241198 (+)	642	WP_002309986.1	copper homeostasis protein CutC	-
FZP47_RS11075 (FZP47_11075)	mgtE	2241258..2242619 (-)	1362	WP_002315660.1	magnesium transporter	-
FZP47_RS11080 (FZP47_11080)	-	2242637..2243536 (-)	900	WP_002315659.1	RluA family pseudouridine synthase	-
FZP47_RS11085 (FZP47_11085)	-	2243538..2244335 (-)	798	WP_002315658.1	NAD kinase	-
FZP47_RS11090 (FZP47_11090)	-	2244310..2245017 (-)	708	WP_002309982.1	GTP pyrophosphokinase family protein	-
FZP47_RS11095 (FZP47_11095)	-	2245148..2245723 (+)	576	WP_002315657.1	CYTH domain-containing protein	-
FZP47_RS11100 (FZP47_11100)	-	2245841..2246518 (+)	678	WP_002328914.1	ClpXP adapter SpxH family protein	-
FZP47_RS11105 (FZP47_11105)	pepF	2246590..2248398 (-)	1809	WP_002315655.1	oligoendopeptidase F	Regulator
FZP47_RS11110 (FZP47_11110)	-	2248577..2249575 (-)	999	WP_002328913.1	competence protein CoiA	-
FZP47_RS11115 (FZP47_11115)	-	2249673..2250326 (-)	654	WP_002328912.1	adaptor protein MecA	-
FZP47_RS11120 (FZP47_11120)	-	2250696..2251655 (+)	960	WP_002293280.1	IS30-like element IS6770 family transposase	-

Sequence

Protein

• Length: 602 a.a.
• Molecular weight: 69679.05 Da
• Isoelectric Point: 4.7044

>NTDB_id=384483 FZP47_RS11105 WP_002315655.1 2246590..2248398(-) (pepF) [Enterococcus faecium strain DMEA02]
MEVKQLPKREELPENLTWDLTKIFSSDQEFDEKYLELSEKLKKSEKYKGTLDQGASQFLDAIEFVLSVYRQTEIIYVYAH
LKNDQDTGNTEYQALYARASSLFSKVSEAVSWFEPEILQLSDERIWQYFKEEPKLEVYRHYIQQIVDNRAHVLSADQESL
LAGAGEIFEASSDTFAVLNNADLVFPTIEGENGEKVQLSHGVYGQLLESTDRSVREAAFKGLYSVYEQFRNTFASTLSTH
IKGHNFKAKVRNYSSAREASLSNNHIPESVYDTLVAVVNKHLPLLHRYMELRKRLLEVEKLHMYDLYTPVLGEAPITFTY
EEAKEKALEALKPMGEEYMTIVEKAFSERWIDVVENKGKRSGAYSSGSYDTNPYILLNWHDTLDQLFTLVHEMGHSVHSY
FTRSNQPYVYGDYSIFLAEIASTTNENILTEYLLETEKDPRVRAYVLNHYLDGFKGTVFRQTQFAEFEHFMHTEDEKGVP
LTSEYLSDSYGKLNAKYYGPAVEEDPEIKFEWSRIPHFYYNYYVFQYSTGFSAASALAKRILSQEPDALENYLAYLKAGN
SDYPVEVMKKAGVDMTQAAYIEDAMSMFEQRLNELEELIDRL

Nucleotide

• Length: 1809 bp

>NTDB_id=384483 FZP47_RS11105 WP_002315655.1 2246590..2248398(-) (pepF) [Enterococcus faecium strain DMEA02]
ATGGAAGTAAAGCAGTTGCCAAAACGCGAAGAATTGCCTGAAAATTTAACTTGGGACTTGACCAAGATCTTTTCAAGCGA
CCAAGAATTTGATGAGAAATATCTAGAATTATCAGAAAAGTTAAAAAAATCTGAAAAATACAAAGGAACACTTGATCAAG
GGGCTTCTCAATTTCTTGATGCGATTGAATTTGTGTTGAGTGTTTATCGCCAAACTGAAATCATTTATGTCTATGCGCAC
CTTAAAAACGATCAAGATACTGGGAATACAGAATATCAAGCGCTTTATGCAAGAGCAAGTAGTTTGTTTTCAAAGGTTAG
TGAAGCTGTTTCCTGGTTTGAACCAGAAATATTGCAGTTATCAGATGAACGGATTTGGCAATATTTCAAAGAAGAACCGA
AGTTAGAAGTCTATCGTCACTATATCCAGCAAATAGTAGATAATCGTGCCCATGTTTTATCTGCCGATCAGGAATCGCTT
CTTGCAGGAGCAGGTGAAATCTTTGAGGCTTCAAGTGATACATTTGCTGTTTTGAATAATGCAGATTTAGTTTTCCCAAC
GATCGAAGGAGAGAATGGTGAAAAAGTCCAATTATCTCATGGCGTGTACGGTCAGTTGCTAGAAAGCACGGATCGAAGTG
TTCGCGAAGCCGCATTTAAAGGGTTGTACAGTGTTTATGAACAATTTAGAAATACGTTTGCTTCTACTTTAAGTACGCAT
ATAAAAGGACATAATTTTAAAGCAAAAGTTCGTAATTACAGCTCTGCCAGAGAAGCATCTTTGAGCAATAATCATATTCC
TGAAAGTGTATACGACACTTTGGTAGCCGTGGTAAACAAGCATTTGCCTTTGCTGCATCGATATATGGAATTACGGAAAC
GTTTATTAGAAGTGGAAAAACTGCACATGTACGATCTTTATACACCGGTCTTAGGAGAAGCTCCAATCACCTTTACGTAT
GAAGAAGCAAAAGAGAAAGCTTTGGAAGCACTGAAGCCAATGGGTGAAGAGTACATGACTATTGTAGAAAAAGCATTCTC
TGAACGTTGGATCGATGTTGTCGAAAATAAAGGAAAACGAAGTGGTGCCTATTCTTCGGGAAGCTATGACACAAATCCAT
ATATTTTATTGAATTGGCATGATACATTGGATCAGCTGTTTACGCTTGTCCACGAAATGGGACATAGTGTCCACAGTTAT
TTCACACGGTCGAACCAGCCTTATGTATACGGTGACTACTCCATCTTTTTAGCAGAAATTGCTTCGACAACGAACGAAAA
TATCCTAACAGAATATTTATTGGAAACAGAAAAAGACCCTCGTGTCCGGGCTTATGTGCTCAACCATTACTTGGATGGAT
TTAAAGGAACAGTTTTCCGCCAGACACAATTTGCTGAATTCGAGCACTTCATGCATACGGAAGATGAAAAAGGTGTGCCA
TTGACTAGTGAATATCTAAGTGATAGTTATGGTAAATTGAATGCAAAATATTATGGTCCGGCAGTCGAAGAAGATCCAGA
AATCAAATTTGAATGGTCACGGATCCCGCATTTTTACTATAATTACTATGTCTTCCAATACTCGACTGGTTTTTCTGCTG
CTTCAGCGTTGGCGAAAAGAATACTCAGTCAGGAACCAGATGCGCTAGAGAACTATTTGGCTTATCTAAAAGCTGGTAAC
AGTGATTATCCTGTTGAAGTGATGAAAAAAGCAGGAGTAGATATGACACAGGCTGCGTATATCGAAGATGCAATGTCGAT
GTTTGAACAACGACTAAACGAATTAGAAGAATTGATTGATCGTTTATAA

Domains

Predicted by InterproScan.

• Oligopeptidase F (Peptidase_M3_N) (116-185)

• Peptidase family M3 (Peptidase_M3) (206-586)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pepF	Streptococcus salivarius strain HSISS4	55.649	98.505	0.548