Detailed information NTG0383546

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: FY406_RS00925
• Genome accession: NZ_CP043405
• Coordinates: 198932..201193 (+)
• Length: 753 a.a.
• NCBI ID: WP_003089336.1
• Uniprot ID: A0A7X9QGN9
• Organism: Streptococcus ratti strain ATCC 31377
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 193932..206193

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FY406_RS00900 (FY406_00900)	-	194999..195463 (-)	465	WP_003089329.1	FeoA domain-containing protein	-
FY406_RS00905 (FY406_00905)	-	195844..196578 (-)	735	WP_003089331.1	amino acid ABC transporter ATP-binding protein	-
FY406_RS00910 (FY406_00910)	-	196578..197264 (-)	687	WP_003089332.1	amino acid ABC transporter permease	-
FY406_RS00915 (FY406_00915)	-	197391..197621 (-)	231	WP_003089333.1	DUF1797 family protein	-
FY406_RS00920 (FY406_00920)	argF	197697..198677 (-)	981	WP_003089335.1	ornithine carbamoyltransferase	-
FY406_RS00925 (FY406_00925)	clpE	198932..201193 (+)	2262	WP_003089336.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
FY406_RS00930 (FY406_00930)	-	201384..201859 (+)	476	Protein_182	NUDIX domain-containing protein	-
FY406_RS00935 (FY406_00935)	-	201927..202229 (+)	303	WP_003089340.1	DUF1827 family protein	-
FY406_RS00940 (FY406_00940)	ileS	202546..205338 (-)	2793	WP_003089342.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 753 a.a.
• Molecular weight: 83790.48 Da
• Isoelectric Point: 4.8304

>NTDB_id=383546 FY406_RS00925 WP_003089336.1 198932..201193(+) (clpE) [Streptococcus ratti strain ATCC 31377]
MLCQNCNLNEATIHLYTSVNGQQKQVDLCQNCYQIMKTDPENNFLNNPSHQNSSSINPFFDDFFGDLNNFRAFNQDLPNS
PQTQSGGNGGGNNRRPGGPRQQGPQRPNGLLEEFGINLTDIARKGEIDPVIGRDDEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDNDVPQKLQGKNVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHHVKYTDEAIE
AAANLSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFVDPKEIDHRLAEAENLKAQATRDEDYEKAAYFRDQIAKYKEMQS
AKIDEQNTPIITEKNIEAIVEQKTNIPVGELKEKEQSQLIHLADDLKQHVIGQDAAVDKIAKAIRRNRVGLGTPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGTSEASVGFGASREGRTNSVLGELGNFFSPEFMNRFDG
IIEFQALSKDNLLKIVDLMLDDVNNRLAVNDIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLENPDQ
KNLKAVMTSQGNISIKAANHKVETVANTASEAE

Nucleotide

• Length: 2262 bp

>NTDB_id=383546 FY406_RS00925 WP_003089336.1 198932..201193(+) (clpE) [Streptococcus ratti strain ATCC 31377]
ATGCTCTGTCAAAATTGTAATTTAAATGAAGCGACTATTCACTTGTACACAAGTGTTAACGGTCAGCAAAAGCAGGTTGA
TCTCTGCCAAAATTGCTATCAAATTATGAAAACAGATCCTGAAAACAACTTTTTGAATAATCCTTCCCATCAAAATTCTT
CATCTATTAATCCTTTCTTTGATGATTTCTTTGGAGATTTGAATAATTTCCGAGCCTTTAATCAAGATCTGCCAAACTCC
CCGCAGACTCAGTCAGGCGGCAATGGCGGCGGAAATAATCGGCGTCCCGGTGGACCTCGTCAGCAGGGTCCTCAAAGACC
AAACGGTCTGCTGGAAGAATTTGGCATCAATTTAACAGATATTGCCCGCAAGGGAGAAATTGATCCTGTTATCGGCCGTG
ACGATGAAATTACCCGGGTCATTGAAATTCTCAACCGCCGAACTAAAAACAATCCTGTTCTCATCGGAGAACCCGGTGTT
GGTAAGACGGCTGTTGTTGAAGGACTTGCTCAAAAAATTGTTGACAACGATGTCCCTCAAAAACTGCAAGGCAAAAATGT
CATCCGCCTTGATGTCGTCAGCCTCGTCCAAGGTACAGGCATCAGAGGACAGTTCGAGGAGCGGATGCAAAAATTAATGG
AAGAAATCCGGCAGCGCCAGGATGTCATCCTCTTCATTGATGAAATCCATGAAATCGTCGGTGCCGGTTCTGCCGGTGAT
GGCAACATGGATGCCGGTAACATTTTGAAGCCCGCTCTGGCCCGTGGAGAACTCCAGCTAGTCGGTGCTACAACGCTCAA
TGAATACCGAATCATTGAAAAAGATGCCGCTCTGGAGCGTCGGATGCAGCCAGTCAAGGTTGATGAGCCTAGTGTTGAAG
AAACAATCACCATTTTAAAGGGTATTCAGCCTAAATACGAAGACTACCATCATGTCAAGTATACTGACGAAGCTATCGAA
GCAGCTGCCAATCTGTCTAACCGCTATATCCAGGACCGCTTCCTGCCAGACAAGGCCATTGACCTGCTGGACGAATCTGG
TTCTAAGATGAATCTGACGCTTAACTTTGTAGATCCAAAAGAAATTGATCACCGCTTGGCTGAAGCTGAAAATCTAAAAG
CTCAGGCAACTCGCGATGAAGATTACGAAAAGGCAGCCTACTTCCGCGATCAGATTGCCAAATATAAGGAAATGCAGTCT
GCTAAGATCGATGAACAAAACACACCAATCATCACAGAAAAGAATATTGAAGCCATTGTTGAACAAAAAACTAACATTCC
TGTTGGTGAGCTCAAAGAAAAAGAACAATCGCAATTAATCCATCTGGCTGATGATTTAAAACAGCACGTTATCGGACAAG
ATGCGGCCGTTGACAAAATTGCTAAGGCTATCCGGCGCAACCGTGTCGGGCTGGGAACACCAAACCGGCCAATCGGAAGC
TTCCTCTTTGTAGGACCTACCGGTGTCGGCAAGACGGAACTGTCCAAGCAATTAGCTATTGAGCTCTTTGGTTCTGCCGA
CAGTATGATTCGCTTTGATATGAGTGAATATATGGAAAAACATGCTGTCGCTAAACTTGTCGGAGCTCCTCCAGGATACG
TTGGCTATGAAGAAGCCGGACAGCTGACGGAAAAAGTCCGCCGCAATCCATATTCTCTCATCTTACTTGATGAGGTTGAA
AAAGCCCATCCAGATGTCATGCACATGTTCCTGCAGGTCTTGGATGACGGCCGCTTGACTGATGGTCAGGGTCGCACAGT
CAGCTTCAAAGATACCATTATTATCATGACTTCCAATGCCGGTACAGGAACGTCTGAAGCCAGTGTTGGCTTTGGTGCCA
GCCGAGAAGGCCGGACGAATTCTGTTCTCGGTGAATTAGGCAACTTCTTCAGTCCCGAATTCATGAATCGTTTTGACGGC
ATCATCGAGTTCCAAGCACTGAGCAAGGACAATCTGCTGAAAATCGTTGACCTCATGCTGGATGACGTTAATAACCGCTT
AGCAGTTAATGACATTCATCTTGATGTTACTGACAAGGTTAAGGAAAAATTGGTTGATCTGGGTTACGATCCAAAAATGG
GTGCGAGACCGCTTCGCAGAACTATTCAAGATCATATTGAAGATGCCATTACCGATTTCTACCTTGAAAACCCTGATCAA
AAGAACTTAAAAGCTGTCATGACCAGCCAGGGAAATATCAGTATCAAGGCTGCTAATCATAAGGTTGAAACAGTAGCTAA
TACAGCGTCAGAGGCAGAATAG

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (476-639)

• ATPase family associated with various cellular activities (AAA) (AAA) (153-272)

• AAA lid domain (AAA_lid_9) (291-388)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (647-718)

3D structure

• AlphaFold DB: A0A7X9QGN9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	91.379	100	0.915
clpE	Streptococcus pneumoniae Rx1	83.401	98.406	0.821
clpE	Streptococcus pneumoniae D39	83.401	98.406	0.821
clpE	Streptococcus pneumoniae R6	83.401	98.406	0.821
clpE	Streptococcus pneumoniae TIGR4	83.266	98.406	0.819
clpC	Lactococcus lactis subsp. cremoris KW2	76.393	100	0.765
clpC	Bacillus subtilis subsp. subtilis str. 168	51.488	89.243	0.459
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.248	86.853	0.41
clpC	Streptococcus pneumoniae Rx1	48.631	82.47	0.401
clpC	Streptococcus pneumoniae D39	48.631	82.47	0.401
clpC	Streptococcus pneumoniae TIGR4	48.47	82.47	0.4
clpC	Streptococcus thermophilus LMD-9	46.72	83.001	0.388
clpC	Streptococcus mutans UA159	46.549	82.736	0.385
clpC	Streptococcus thermophilus LMG 18311	46.4	83.001	0.385