Detailed information NTG0383269

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FZC50_RS10310
• Genome accession: NZ_CP043392
• Coordinates: 2032476..2033519 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NRS384-rpoB-H481N-NCV
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2027476..2038519

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FZC50_RS10280 (FZC50_10280)	-	2027894..2029150 (-)	1257	WP_001795438.1	aminopeptidase	-
FZC50_RS10285 (FZC50_10285)	-	2029153..2029353 (-)	201	WP_000180461.1	DUF1128 family protein	-
FZC50_RS10290 (FZC50_10290)	-	2029500..2029964 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FZC50_RS10295 (FZC50_10295)	-	2029971..2030246 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FZC50_RS10300 (FZC50_10300)	-	2030524..2031741 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FZC50_RS10305 (FZC50_10305)	vraR	2031857..2032486 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
FZC50_RS10310 (FZC50_10310)	vraS	2032476..2033519 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FZC50_RS10315 (FZC50_10315)	liaF	2033516..2034217 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FZC50_RS10320 (FZC50_10320)	-	2034232..2034618 (-)	387	WP_001110179.1	hypothetical protein	-
FZC50_RS10325 (FZC50_10325)	map	2034835..2035593 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
FZC50_RS10330 (FZC50_10330)	-	2036121..2037107 (+)	987	WP_000999713.1	FUSC family protein	-
FZC50_RS10335 (FZC50_10335)	-	2037597..2038010 (-)	414	WP_001549145.1	hypothetical protein	-
FZC50_RS10340 (FZC50_10340)	-	2038039..2038149 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=383269 FZC50_RS10310 WP_001017131.1 2032476..2033519(-) (vraS) [Staphylococcus aureus strain NRS384-rpoB-H481N-NCV]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=383269 FZC50_RS10310 WP_001017131.1 2032476..2033519(-) (vraS) [Staphylococcus aureus strain NRS384-rpoB-H481N-NCV]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1