Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   FQP84_RS05750 Genome accession   NZ_CP043302
Coordinates   1116616..1117977 (+) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus aureus strain 16445     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 1090694..1119602 1116616..1117977 within 0


Gene organization within MGE regions


Location: 1090694..1119602
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FQP84_RS05615 (FQP84_05615) - 1090694..1092208 (+) 1515 WP_001587831.1 hypothetical protein -
  FQP84_RS05620 (FQP84_05620) - 1092279..1093418 (-) 1140 Protein_1079 IS3 family transposase -
  FQP84_RS05625 (FQP84_05625) ssb 1093653..1093946 (+) 294 WP_001587828.1 cassette chromosome ssDNA-binding protein -
  FQP84_RS05630 (FQP84_05630) cch1 1093946..1095739 (+) 1794 WP_031806891.1 cassette chromosome replicative helicase -
  FQP84_RS05635 (FQP84_05635) ccrA 1095973..1097322 (+) 1350 WP_031806890.1 cassette chromosome recombinase CcrA Machinery gene
  FQP84_RS05640 (FQP84_05640) ccrB 1097344..1098972 (+) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  FQP84_RS05645 (FQP84_05645) - 1099494..1099844 (+) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  FQP84_RS05655 (FQP84_05655) - 1099931..1100242 (+) 312 WP_000700851.1 DUF960 family protein -
  FQP84_RS05660 (FQP84_05660) - 1100257..1100763 (+) 507 WP_001092189.1 DUF1643 domain-containing protein -
  FQP84_RS05665 (FQP84_05665) - 1100812..1102422 (+) 1611 Protein_1087 IS1182 family transposase -
  FQP84_RS05670 (FQP84_05670) - 1102413..1102654 (-) 242 Protein_1088 type I restriction enzyme endonuclease domain-containing protein -
  FQP84_RS05675 (FQP84_05675) - 1102644..1103630 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  FQP84_RS05680 (FQP84_05680) mecA 1103727..1105736 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  FQP84_RS05685 (FQP84_05685) - 1105782..1106210 (-) 429 WP_000872606.1 MaoC family dehydratase -
  FQP84_RS05690 (FQP84_05690) - 1106307..1107050 (-) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  FQP84_RS05700 (FQP84_05700) - 1107927..1108316 (-) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  FQP84_RS05705 (FQP84_05705) - 1108352..1109026 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  FQP84_RS05710 (FQP84_05710) - 1109058..1109297 (-) 240 WP_001282728.1 hypothetical protein -
  FQP84_RS05715 (FQP84_05715) - 1109712..1110968 (-) 1257 WP_149590267.1 MrcB family domain-containing protein -
  FQP84_RS05720 (FQP84_05720) - 1112194..1114119 (-) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  FQP84_RS05730 (FQP84_05730) - 1114449..1114775 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  FQP84_RS05735 (FQP84_05735) - 1114982..1115341 (+) 360 WP_001631039.1 hypothetical protein -
  FQP84_RS05740 (FQP84_05740) - 1115453..1115791 (-) 339 Protein_1100 recombinase family protein -
  FQP84_RS05745 (FQP84_05745) - 1115800..1116429 (+) 630 Protein_1101 hypothetical protein -
  FQP84_RS05750 (FQP84_05750) ccrA 1116616..1117977 (+) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  FQP84_RS05755 (FQP84_05755) ccrB 1117974..1119602 (+) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=382713 FQP84_RS05750 WP_001631036.1 1116616..1117977(+) (ccrA) [Staphylococcus aureus strain 16445]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=382713 FQP84_RS05750 WP_001631036.1 1116616..1117977(+) (ccrA) [Staphylococcus aureus strain 16445]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494

Multiple sequence alignment