Detailed information NTG0378046

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: HB750_RS09725
• Genome accession: NZ_CP050273
• Coordinates: 1982188..1984737 (+)
• Length: 849 a.a.
• NCBI ID: WP_019804940.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain P1
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1977188..1989737

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB750_RS09695 (HB750_09695)	argS	1977288..1978979 (-)	1692	WP_002311793.1	arginine--tRNA ligase	-
HB750_RS09700 (HB750_09700)	-	1979080..1979520 (-)	441	Protein_1876	arginine repressor	-
HB750_RS10530 (HB750_09705)	-	1979758..1980412 (+)	655	Protein_1877	B3/4 domain-containing protein	-
HB750_RS09710 (HB750_09710)	-	1980432..1980917 (+)	486	WP_019804942.1	cyclic nucleotide-binding domain-containing protein	-
HB750_RS09715 (HB750_09715)	argR	1981414..1981851 (+)	438	WP_002262400.1	arginine repressor	-
HB750_RS09720 (HB750_09720)	-	1981848..1982195 (+)	348	WP_019804941.1	YlbF family regulator	-
HB750_RS09725 (HB750_09725)	hexA	1982188..1984737 (+)	2550	WP_019804940.1	DNA mismatch repair protein MutS	Machinery gene
HB750_RS09730 (HB750_09730)	-	1984732..1985010 (-)	279	Protein_1882	transposase	-
HB750_RS09735 (HB750_09735)	hexB	1985235..1987190 (+)	1956	WP_019804939.1	DNA mismatch repair endonuclease MutL	Machinery gene
HB750_RS09740 (HB750_09740)	ruvA	1987375..1987968 (+)	594	WP_002262395.1	Holliday junction branch migration protein RuvA	Machinery gene
HB750_RS09745 (HB750_09745)	-	1988050..1988610 (+)	561	WP_002271569.1	DNA-3-methyladenine glycosylase I	-

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 95255.54 Da
• Isoelectric Point: 4.9476

>NTDB_id=378046 HB750_RS09725 WP_019804940.1 1982188..1984737(+) (hexA) [Streptococcus mutans strain P1]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
DLGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSTKPDSANNFLVSLDTDGSQFGLSYMDLSTGEFYATTLADLPA
VRSEVLNLKARELVIGFELSENEEQLFRKQMNLLLSFEKTVYDDVHLLDDQLKAIELAAAGKLLQYVHNTQKRELSHLQK
LVHYEIKDYLQMAYATKSSLDLLENARSGKKHGSLYWLLDETKTAMGTRLLRTWIDRPLVSSSLISKRQDIIQTFLDHFF
ERSDLSDSLKGVYDIERLASRVSFGKANPKDLLQLGQTLSQVPVIKTILESFASSSLESLINQIDTLPELEALIRSAVDS
NAPITITEGGMIREGFDETLDKYRTVMREGTSWIADIETKERQKSGISTLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKA
TLKNSERFGTAELAKIEGEMLEAREESANLEYDIFMRIRSQVESYIERLQNLAKSLATVDVLQSLAVVAENNHYVRPSFN
HQQEISIENGRHAVVEKVMGSQEYIPNTINFDQKTSIQLITGPNMSGKSTYMRQLALTVIMAQLGSFVAADSADLPIFDA
IFTRIGAADDLISGQSTFMVEMMEANHAIKAATPNSLILFDELGRGTATYDGMALAQAIIEYIHNKVGAKTLFATHYHEL
TDLSTTLTSLVNVHVATLEKDGEVTFLHKIADGPADKSYGIHVAKIAGLPKDLLNRADHILVDLEKMSAAVSVNLKNETK
ESQPVEEQLSLFAIDNNYEELIKKLKQLDLTNLTPRESMNALFDLKELL

Nucleotide

• Length: 2550 bp

>NTDB_id=378046 HB750_RS09725 WP_019804940.1 1982188..1984737(+) (hexA) [Streptococcus mutans strain P1]
ATGACTAAGGAAAAACTCTCTCCAGGAATGCAACAGTATTTGGATATCAAAAAAGACTATCCAGATGCTTTTTTGCTTTT
CCGCATGGGAGATTTTTATGAACTATTTTATGATGATGCTATCAAGGCCGCTCAAATTTTAGAAATTAGCTTAACAAGTC
GTAATAAAAATGCTGACAATCCTATTCCGATGGCTGGTGTCCCTTATCATTCAGCTCAACAGTATATTGATGTTTTGATT
GATTTGGGTTATAAGGTTGCCATTGCTGAGCAGATGGAAGACCCTAAAAAAGCTGTTGGCGTTGTCAAACGTGAAGTGGT
TCAAGTGATTACCCCGGGTACTGTTGTTGATTCAACTAAGCCAGACAGTGCTAATAATTTTTTAGTCTCTCTGGATACTG
ATGGCAGTCAGTTTGGCCTTTCTTACATGGATTTATCTACTGGGGAATTTTATGCGACAACATTAGCAGATTTGCCAGCA
GTGAGAAGCGAAGTCCTCAATCTCAAGGCGCGTGAATTAGTTATTGGTTTTGAACTGAGTGAGAATGAAGAACAGCTTTT
TCGTAAGCAGATGAACCTGCTCTTATCTTTTGAAAAAACTGTCTATGACGATGTACATTTATTGGATGATCAATTAAAAG
CAATAGAACTTGCTGCAGCTGGCAAACTCTTGCAATATGTTCATAACACACAAAAACGTGAGTTGAGTCATTTGCAAAAG
TTGGTGCATTATGAAATCAAAGATTACTTGCAGATGGCTTATGCTACAAAATCTAGCTTGGATCTGTTAGAAAATGCCAG
AAGCGGGAAAAAACACGGCAGTCTCTACTGGCTTTTAGATGAGACAAAAACAGCTATGGGGACACGCCTTTTGCGAACTT
GGATTGATCGTCCTTTGGTCAGTTCAAGCCTTATCAGTAAACGTCAAGATATTATTCAGACTTTTCTAGATCACTTTTTT
GAGCGCAGTGATCTTAGTGACAGCTTAAAAGGTGTTTATGATATTGAACGTTTGGCCAGCCGTGTTTCATTTGGGAAGGC
CAATCCTAAGGATTTATTGCAATTGGGTCAGACCTTAAGTCAAGTTCCTGTCATTAAGACCATTCTTGAAAGTTTTGCCA
GTTCTAGTTTGGAAAGCCTAATTAATCAGATTGATACTCTTCCAGAATTGGAAGCATTGATTCGTTCGGCTGTTGACTCT
AATGCACCTATAACTATTACAGAAGGCGGTATGATTCGAGAGGGGTTTGATGAAACTTTAGATAAGTATCGAACGGTAAT
GCGCGAAGGGACGAGTTGGATTGCTGACATTGAGACTAAGGAACGTCAGAAAAGCGGCATCTCAACCTTGAAGATTGATT
ATAACAAAAAAGACGGTTATTATTTCCATGTCACCAACTCTAATTTGTCTTTAGTACCAGATTACTTCTTTAGAAAGGCA
ACGCTTAAAAATTCTGAGCGCTTTGGGACAGCAGAGCTTGCAAAAATTGAAGGTGAAATGTTAGAAGCGCGTGAAGAATC
AGCCAATTTAGAATATGATATTTTCATGCGTATCAGATCACAGGTTGAATCTTATATTGAGCGTCTTCAAAATCTGGCCA
AGAGTTTAGCGACTGTTGATGTTTTGCAAAGTTTAGCAGTAGTAGCTGAGAATAATCATTATGTCAGACCTTCTTTTAAT
CATCAGCAGGAAATCAGTATTGAAAATGGTCGCCATGCTGTTGTTGAGAAGGTTATGGGGAGCCAAGAATATATTCCCAA
TACTATCAATTTTGACCAAAAGACTAGTATTCAACTGATTACTGGACCTAATATGAGCGGTAAGTCAACTTACATGCGGC
AATTAGCTCTGACAGTTATTATGGCTCAATTAGGTTCTTTTGTAGCAGCTGATTCAGCTGATTTGCCGATTTTTGATGCT
ATTTTTACACGTATTGGTGCTGCAGATGATTTAATTTCAGGGCAGTCTACCTTTATGGTAGAGATGATGGAAGCCAATCA
TGCTATCAAGGCAGCGACACCTAATTCACTCATTTTATTTGATGAATTAGGACGTGGTACAGCAACTTATGATGGTATGG
CTTTAGCACAGGCTATTATTGAGTATATTCATAATAAAGTTGGGGCTAAAACGCTATTTGCTACCCATTATCATGAGTTG
ACAGACTTGTCAACTACATTGACAAGTCTTGTCAATGTACATGTTGCTACTCTTGAAAAAGATGGAGAGGTCACTTTTCT
TCATAAAATTGCTGATGGACCAGCTGATAAATCTTATGGAATCCATGTTGCTAAAATTGCCGGCTTGCCTAAAGATTTAC
TTAATCGAGCTGATCACATATTAGTTGATTTAGAAAAAATGAGTGCAGCTGTCTCAGTCAATCTTAAAAACGAGACCAAA
GAAAGCCAACCTGTGGAAGAGCAGTTGTCACTTTTTGCTATTGATAATAATTATGAAGAATTAATCAAAAAATTGAAACA
GTTGGACCTTACCAATTTAACACCAAGAGAATCCATGAATGCCTTATTTGATTTAAAGGAACTATTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	72.15	100	0.723
mutS	Pseudomonas stutzeri strain ATCC 17587	37.223	100	0.376