Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC   Type   Machinery gene
Locus tag   HB753_RS00095 Genome accession   NZ_CP050270
Coordinates   24261..24575 (+) Length   104 a.a.
NCBI ID   WP_002263437.1    Uniprot ID   Q8DS51
Organism   Streptococcus mutans strain S4     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 19261..29575
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HB753_RS00080 (HB753_00080) - 21840..22223 (+) 384 WP_002263434.1 DUF1033 family protein -
  HB753_RS00085 (HB753_00085) comGA 22353..23294 (+) 942 WP_019804919.1 competence type IV pilus ATPase ComGA Machinery gene
  HB753_RS00090 (HB753_00090) comGB 23230..24261 (+) 1032 WP_255262721.1 competence type IV pilus assembly protein ComGB Machinery gene
  HB753_RS00095 (HB753_00095) comGC 24261..24575 (+) 315 WP_002263437.1 competence type IV pilus major pilin ComGC Machinery gene
  HB753_RS00100 (HB753_00100) comGD 24562..24966 (+) 405 WP_002263438.1 competence type IV pilus minor pilin ComGD Machinery gene
  HB753_RS00105 (HB753_00105) comGE 24938..25231 (+) 294 WP_002263439.1 competence type IV pilus minor pilin ComGE Machinery gene
  HB753_RS00110 (HB753_00110) comGF 25218..25652 (+) 435 WP_002274770.1 competence type IV pilus minor pilin ComGF Machinery gene
  HB753_RS00115 (HB753_00115) comGG 25630..26019 (+) 390 WP_002263441.1 competence type IV pilus minor pilin ComGG Machinery gene
  HB753_RS00120 (HB753_00120) comGH 26074..27027 (+) 954 WP_019317550.1 class I SAM-dependent methyltransferase Machinery gene
  HB753_RS00125 (HB753_00125) - 27086..28285 (+) 1200 WP_002263443.1 acetate kinase -
  HB753_RS00130 (HB753_00130) tnpA 28498..28961 (+) 464 Protein_20 IS200/IS605 family transposase -

Sequence

Protein


Download         Length: 104 a.a.        Molecular weight: 11591.60 Da        Isoelectric Point: 10.2206

>NTDB_id=377592 HB753_RS00095 WP_002263437.1 24261..24575(+) (comGC) [Streptococcus mutans strain S4]
MKKIKRVSVRAFTLIEMLVVLLIISILLLLFVPNLTKQKDKVKDTGGSAVVKVVESQAELYELNKTDSATLSKLVASGDI
TQEQANSYKDYYAKHPSKTRHVAN

Nucleotide


Download         Length: 315 bp        

>NTDB_id=377592 HB753_RS00095 WP_002263437.1 24261..24575(+) (comGC) [Streptococcus mutans strain S4]
ATGAAAAAGATCAAGAGAGTCAGTGTACGAGCTTTTACGCTTATAGAAATGTTAGTAGTTCTTCTCATTATTAGTATTCT
TTTACTATTATTTGTTCCTAATTTAACTAAGCAAAAAGATAAGGTAAAAGATACTGGCGGTTCTGCCGTGGTTAAAGTTG
TAGAAAGTCAGGCTGAGCTTTATGAGCTTAATAAAACCGATTCTGCTACTCTTTCTAAATTAGTAGCTAGTGGTGATATT
ACACAAGAACAGGCAAATTCATACAAGGATTACTATGCAAAACACCCAAGTAAAACACGGCATGTCGCGAATTAA

Domains

Predicted by InterProScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(9-30)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DS51

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC Streptococcus mutans UA140

100

100

1
  comGC Streptococcus mutans UA159

100

100

1
  comGC Streptococcus gordonii str. Challis substr. CH1

71.429

100

0.721
  comGC/cglC Streptococcus mitis SK321

66.667

95.192

0.635
  comGC/cglC Streptococcus mitis NCTC 12261

69.565

88.462

0.615
  comGC/cglC Streptococcus pneumoniae R6

63.636

95.192

0.606
  comGC/cglC Streptococcus pneumoniae Rx1

63.636

95.192

0.606
  comGC/cglC Streptococcus pneumoniae D39

63.636

95.192

0.606
  comGC/cglC Streptococcus pneumoniae TIGR4

63.636

95.192

0.606
  comGC Lactococcus lactis subsp. cremoris KW2

55.446

97.115

0.538
  comGC Streptococcus suis isolate S10

60.227

84.615

0.51

Multiple sequence alignment