Detailed information NTG0375006

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: G8B37_RS07445
• Genome accession: NZ_CP049695
• Coordinates: 1480525..1481274 (-)
• Length: 249 a.a.
• NCBI ID: WP_011528343.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain ABC76
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1475525..1486274

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B37_RS07430 (G8B37_07480)	-	1477476..1478840 (+)	1365	Protein_1421	bacteriocin secretion accessory protein	-
G8B37_RS07435 (G8B37_07485)	-	1478917..1479042 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
G8B37_RS07440 (G8B37_07490)	-	1479190..1480524 (-)	1335	WP_011528344.1	sensor histidine kinase	-
G8B37_RS07445 (G8B37_07495)	comE/blpR	1480525..1481274 (-)	750	WP_011528343.1	response regulator transcription factor	Regulator
G8B37_RS09555	-	1481652..1482736 (-)	1085	Protein_1425	IS3 family transposase	-
G8B37_RS07470 (G8B37_07520)	-	1482856..1483173 (-)	318	WP_021299375.1	hypothetical protein	-
G8B37_RS07475 (G8B37_07525)	-	1483222..1483449 (-)	228	WP_042769846.1	Blp family class II bacteriocin	-
G8B37_RS09560	-	1483847..1483975 (-)	129	WP_002994583.1	hypothetical protein	-
G8B37_RS09685 (G8B37_07530)	-	1484060..1484344 (-)	285	WP_079891230.1	CPBP family intramembrane glutamic endopeptidase	-
G8B37_RS07485 (G8B37_07535)	-	1484665..1484841 (-)	177	WP_002994581.1	hypothetical protein	-
G8B37_RS07490 (G8B37_07540)	-	1484819..1485043 (-)	225	WP_002994580.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29119.48 Da
• Isoelectric Point: 6.0419

>NTDB_id=375006 G8B37_RS07445 WP_011528343.1 1480525..1481274(-) (comE/blpR) [Streptococcus pyogenes strain ABC76]
MNIFVLEDDFLHQTRIGKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=375006 G8B37_RS07445 WP_011528343.1 1480525..1481274(-) (comE/blpR) [Streptococcus pyogenes strain ABC76]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGGAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGAGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.098	97.992	0.53
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE1	Streptococcus equinus JB1	41.597	95.582	0.398
comE/comE2	Streptococcus equinus JB1	40.164	97.992	0.394
comE	Streptococcus mitis NCTC 12261	38.4	100	0.386
comE	Streptococcus mitis SK321	38.4	100	0.386
comE	Streptococcus pneumoniae TIGR4	38	100	0.382
comE	Streptococcus pneumoniae Rx1	38	100	0.382
comE	Streptococcus pneumoniae D39	38	100	0.382
comE	Streptococcus pneumoniae R6	38	100	0.382
comE	Streptococcus infantis strain Atu-4	37.698	100	0.382