Detailed information NTG0374995

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: FPL13_RS02090
• Genome accession: NZ_CP041968
• Coordinates: 423243..425522 (-)
• Length: 759 a.a.
• NCBI ID: WP_049513098.1
• Uniprot ID: A0A7L8W3T5
• Organism: Streptococcus sp. KS 6
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	421951..423207	423243..425522	flank	36

Gene organization within MGE regions

Location: 421951..425522

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FPL13_RS02085 (FPL13_02135)	-	421951..423207 (+)	1257	WP_192208641.1	ISL3 family transposase	-
FPL13_RS02090 (FPL13_02140)	clpE	423243..425522 (-)	2280	WP_049513098.1	ATP-dependent Clp protease ATP-binding subunit	Regulator

Sequence

Protein

• Length: 759 a.a.
• Molecular weight: 84559.65 Da
• Isoelectric Point: 4.9167

>NTDB_id=374995 FPL13_RS02090 WP_049513098.1 423243..425522(-) (clpE) [Streptococcus sp. KS 6]
MLCQNCKINESTIHLYTNVNGKQHQVDLCQNCYQIMKTDPNNALFRGMTNMNNQNNLDPFDDFFSNLGNFQNHQEPQTPP
TQSGGGYGNGGYGSNQGGGARQQAPQQPKGLLEEFGINVTEFARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEPG
VGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRSRQDVILFIDEIHEIVGAGAAG
DGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDDAI
EAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLVEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQ
QNKMADQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLISLADDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNRPIG
SFLFVGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEV
EKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEANVGFGAAREGRTNSVLGELGNFFSPEFMNRFD
GIIEFKSLDKENLLKIVDLMLEDVNERLATNDIHLDVTDKVKEKLVNLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPS
EKELKAVMTSNGKIVIKSAKKAENEAGKEIQTPADDNAN

Nucleotide

• Length: 2280 bp

>NTDB_id=374995 FPL13_RS02090 WP_049513098.1 423243..425522(-) (clpE) [Streptococcus sp. KS 6]
ATGCTTTGTCAAAACTGTAAAATAAATGAATCAACCATTCACCTTTACACAAATGTGAATGGAAAACAACACCAAGTCGA
CCTCTGTCAAAATTGTTATCAAATCATGAAAACAGACCCCAATAATGCTCTATTTCGTGGAATGACTAATATGAATAATC
AAAACAACTTAGATCCTTTTGATGACTTCTTTAGTAATCTCGGGAATTTTCAAAACCATCAAGAACCACAAACCCCTCCG
ACTCAATCTGGAGGCGGTTACGGCAATGGAGGTTACGGTTCCAATCAAGGTGGAGGTGCACGCCAGCAAGCTCCGCAACA
GCCTAAAGGCCTCCTAGAAGAATTTGGTATCAATGTAACCGAATTTGCTCGGCGCGGTGAAATTGACCCTGTCATCGGTC
GTGATGAGGAAATCGTCCGCGTCATTGAAATTCTCAACCGTCGGACGAAGAACAACCCTGTCCTCATCGGAGAGCCCGGT
GTCGGTAAAACAGCTGTTGTAGAAGGCTTGGCCCAGAAGATTGTGGACGGTGATGTTCCACACAAACTCCAAGGAAAAGA
AGTCATCCGTTTAGATGTAGTCAGCCTAGTGCAAGGAACTGGTATCCGTGGTCAATTTGAAGAACGAATGCAAAAACTCA
TGGAAGAAATCCGTTCTCGTCAGGATGTGATTTTATTCATTGATGAAATCCATGAAATCGTTGGAGCTGGTGCAGCTGGA
GATGGCAATATGGATGCTGGCAACATCTTAAAACCCGCTCTTGCTCGCGGTGAGCTTCAATTAGTTGGTGCCACAACTCT
CAATGAGTATCGCATTATCGAAAAAGATGCAGCACTGGAACGCCGTATGCAGCCTGTAAAAGTTGATGAACCAACAGTTG
AAGAAACGATCACTATCCTCAAAGGTATTCAAAAGAAATACGAAGACTATCACCACGTCAAATACACAGATGATGCCATT
GAAGCGGCAGCTGTCTTATCCAATCGTTATATCCAAGATCGTTTCTTGCCAGATAAGGCTATTGACTTGCTGGACGAAGC
AGGTTCTAAAATGAATCTGACACTTAACTTTGTCGATCCAAAAGTCATTGATCAACGCTTGGTAGAAGCTGAAAATCTCA
AGGCACAAGCTACTCGTGATGAAGATTTTGAAAAAGCTGCCTATTTCCGTGACCAAATTGCCAAATACAAAGAAATGCAG
CAAAATAAAATGGCAGACCAAGATACACCTATTATCAGTGAAAAAACCATTGAGCATATCATTGAGCAAAAAACAAATAT
CCCAGTTGGTGACCTAAAAGAAAAGGAACAATCGCAACTAATTAGTCTAGCTGATGATTTGAAAGCTCATGTCATCGGTC
AAGATGATGCCGTTGATAAAATTGCCAAAGCTATTCGCCGTAATCGTGTCGGGCTTGGCTCTCCTAATCGACCAATTGGT
TCCTTCCTCTTTGTCGGACCAACCGGTGTCGGTAAAACAGAACTTTCTAAACAATTAGCGATTGAGCTCTTTGGTTCATC
TGACAGCATGATTCGCTTTGATATGTCTGAGTATATGGAAAAACACAGCGTAGCCAAACTCGTTGGAGCACCTCCAGGCT
ATGTTGGCTACGAAGAAGCCGGACAATTGACAGAGCGCGTACGCCGCAATCCTTACTCTCTCATTTTACTTGACGAAGTA
GAAAAAGCGCACCCAGATGTCATGCACATGTTCCTGCAAGTTCTTGATGACGGACGTCTGACAGACGGACAAGGGCGCAC
AGTTAGCTTTAAAGATACGATTATCATTATGACTTCAAACGCTGGTACTGGCAAAGTCGAAGCAAATGTTGGCTTTGGAG
CAGCGCGTGAAGGACGGACTAACTCTGTTCTCGGTGAATTAGGCAACTTCTTCAGTCCAGAATTTATGAACCGCTTTGAC
GGTATTATCGAATTCAAGTCCCTTGATAAGGAAAATCTCCTAAAAATCGTAGACTTGATGCTTGAAGATGTCAATGAACG
GCTTGCAACAAATGACATTCACCTCGACGTGACAGACAAAGTCAAAGAAAAATTAGTTAATTTGGGTTACGATCCGAAAA
TGGGAGCTCGTCCGCTCCGTCGGACAATCCAAGATCACATCGAAGACGCCATTACTGATTACTACCTTGAACACCCAAGT
GAAAAAGAACTCAAGGCTGTCATGACAAGCAACGGCAAGATTGTCATCAAATCAGCTAAAAAAGCTGAAAACGAAGCCGG
CAAAGAAATCCAAACACCAGCAGATGACAATGCTAATTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (648-722)

• AAA domain (Cdc48 subfamily) (AAA_2) (477-640)

• AAA lid domain (AAA_lid_9) (292-389)

• ATPase family associated with various cellular activities (AAA) (AAA) (154-273)

3D structure

• AlphaFold DB: A0A7L8W3T5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	87.651	98.155	0.86
clpE	Streptococcus pneumoniae D39	87.651	98.155	0.86
clpE	Streptococcus pneumoniae R6	87.651	98.155	0.86
clpE	Streptococcus pneumoniae TIGR4	87.517	98.155	0.859
clpE	Streptococcus mutans UA159	85.408	98.419	0.841
clpC	Lactococcus lactis subsp. cremoris KW2	76.974	100	0.771
clpC	Bacillus subtilis subsp. subtilis str. 168	49.713	91.963	0.457
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.325	82.609	0.399
clpC	Streptococcus pneumoniae Rx1	48.148	81.818	0.394
clpC	Streptococcus pneumoniae D39	48.148	81.818	0.394
clpC	Streptococcus pneumoniae TIGR4	47.987	81.818	0.393
clpC	Streptococcus mutans UA159	47.115	82.213	0.387
clpC	Streptococcus thermophilus LMG 18311	46.314	82.213	0.381
clpC	Streptococcus thermophilus LMD-9	46.388	82.082	0.381