Detailed information NTG0374975

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: FPL13_RS00285
• Genome accession: NZ_CP041968
• Coordinates: 41124..43553 (+)
• Length: 809 a.a.
• NCBI ID: WP_049514299.1
• Uniprot ID: A0A7L8W337
• Organism: Streptococcus sp. KS 6
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	44315..45260	41124..43553	flank	762

Gene organization within MGE regions

Location: 41124..45260

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FPL13_RS00285 (FPL13_00290)	clpC	41124..43553 (+)	2430	WP_049514299.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
FPL13_RS00290 (FPL13_00295)	-	43596..44036 (+)	441	WP_049514297.1	GNAT family N-acetyltransferase	-
FPL13_RS00295 (FPL13_00305)	-	44315..45260 (+)	946	Protein_59	IS30 family transposase	-

Sequence

Protein

• Length: 809 a.a.
• Molecular weight: 89885.22 Da
• Isoelectric Point: 6.3652

>NTDB_id=374975 FPL13_RS00285 WP_049514299.1 41124..43553(+) (clpC) [Streptococcus sp. KS 6]
MKYSKALTESIESAQLLASHFETDYLESWQLLIAMANNPYSVAGSVLNDYPLEIDDFEKAAFHITGKIYQQEGSFTIWPF
SHRMKVLFLTAERIAEAVHAKNLGTEHVLLAMLFDRGSLAARLLEFTGFSYEDKEGVLRMTDLRKNLEHKASWGKEDIKA
IRHLNKNTAAAKQTMANMMGMPPSTSGGLEDYTHDLTEMARAGLLEPVVGRDEEISRMLQILSRKTKNNPVLVGDAGVGK
TALVLGLAQRVAAGQVPNELAKMRVLELDLMNVVAGTRFRGDFEERMNNIINDIEADGYVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKYIEKDAALSRRFAKVTIEEPTVADSIAILQGLKKSYEEHHKVVITDSAIET
AVKYAHRYLTSKHLPDSAIDLLDEAAAMVQSKGPQNHVKAELSAADEALMAGDWKKVGTLLEKESQPIVYKLKVKDEDIL
ATLSGLSGIPVQKLTQTDAKKYLHLEKELHKRVIGQNEAISAISRAIRRNQSGIRTSKRPIGSFMFLGPTGVGKTELAKA
LAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNRPYSVLLFDEVEKAHPDIFNVLLQVLDDG
VLTDSKGRKVDFSNTIIIMTSNLGATSLRDDKTVGFGARDARFDHENMEKRMMEELKKSYRPEFINRIDEKVVFHSLTSE
DMQEVVKIMVKPLIVSLAEKGIELKFQPSALKLLAKKGYDPEMGARPLRRTLQTQVEDHLSELLLAGELKTGQSLKVGVK
AGQLKFEVL

Nucleotide

• Length: 2430 bp

>NTDB_id=374975 FPL13_RS00285 WP_049514299.1 41124..43553(+) (clpC) [Streptococcus sp. KS 6]
ATGAAATATTCAAAAGCTTTGACAGAAAGTATTGAATCAGCACAGTTATTGGCAAGTCATTTTGAAACGGATTATTTAGA
GTCTTGGCAGCTGTTGATTGCTATGGCAAATAATCCTTATAGTGTTGCTGGTTCAGTTTTAAATGATTACCCACTTGAAA
TTGATGATTTTGAGAAAGCAGCCTTTCATATCACAGGAAAGATTTATCAACAAGAGGGAAGCTTTACCATTTGGCCATTT
TCTCATCGTATGAAAGTGTTGTTTTTGACAGCTGAGCGAATTGCAGAGGCTGTGCATGCTAAGAATCTTGGGACAGAGCA
TGTGTTGTTAGCTATGCTGTTTGACAGAGGAAGTTTGGCGGCACGTCTCCTTGAATTTACAGGCTTTAGCTATGAGGATA
AAGAAGGCGTTTTGCGCATGACCGATCTTCGGAAAAACTTAGAGCATAAGGCTAGCTGGGGTAAAGAAGATATAAAGGCT
ATTCGCCACTTAAATAAAAATACTGCTGCAGCGAAACAAACGATGGCCAATATGATGGGAATGCCTCCTTCTACCAGCGG
CGGGCTAGAAGACTATACCCATGATTTAACCGAAATGGCTCGTGCTGGTCTTTTAGAACCGGTCGTTGGGCGTGATGAAG
AAATTTCGCGTATGCTTCAGATTTTAAGTCGCAAGACGAAGAATAATCCAGTGTTGGTAGGAGATGCAGGAGTTGGGAAG
ACAGCATTGGTCCTTGGTTTGGCACAGCGTGTGGCTGCTGGTCAGGTGCCAAATGAGCTTGCAAAGATGAGAGTTCTAGA
GCTGGATTTGATGAATGTGGTAGCTGGGACTCGTTTTCGCGGCGATTTTGAAGAGCGGATGAATAATATTATCAATGATA
TTGAAGCAGACGGGTACGTGATTCTCTTCATTGATGAGCTTCATACCATTATGGGTTCTGGCAGCGGGATTGATTCGACA
TTAGATGCAGCGAACATTCTCAAGCCGGCTTTGGCTAGAGGGACACTCAGAACGGTTGGCGCAACGACACAAGAAGAGTA
CCAGAAATATATTGAAAAGGATGCAGCTCTTTCACGGCGATTTGCCAAAGTTACTATTGAAGAGCCGACAGTAGCTGATA
GTATTGCGATTTTACAGGGACTCAAGAAAAGCTATGAAGAACACCACAAGGTGGTGATTACAGATTCAGCGATTGAGACA
GCTGTTAAGTATGCTCATCGTTATCTAACAAGCAAACATCTACCTGACTCGGCGATTGATTTGCTAGATGAAGCTGCTGC
AATGGTACAAAGTAAAGGTCCGCAAAATCATGTAAAAGCAGAATTGAGTGCAGCAGACGAGGCTTTAATGGCAGGCGATT
GGAAAAAAGTTGGCACTTTGTTGGAGAAAGAAAGTCAGCCAATTGTCTACAAACTAAAGGTTAAAGACGAGGATATTTTG
GCAACACTCAGCGGTTTATCGGGCATTCCTGTGCAAAAGCTGACGCAAACAGATGCGAAGAAATACCTCCATTTAGAAAA
GGAACTGCACAAACGGGTCATTGGGCAAAATGAAGCAATTTCTGCTATCAGTCGAGCGATTCGGCGCAATCAATCCGGCA
TCCGCACCAGCAAACGTCCAATTGGTTCCTTTATGTTCTTGGGTCCAACCGGGGTTGGAAAAACTGAGCTGGCTAAGGCT
TTGGCGGAAGTCCTCTTTGATGATGAGTCAGCACTGATTCGCTTTGATATGTCCGAATATATGGAGAAATTTGCTGCCAG
TCGTCTCAATGGAGCGCCTCCAGGTTATGTCGGTTATGAAGAAGGGGGCGAATTGACTGAAAAAGTTCGCAATCGTCCTT
ATTCGGTGCTCCTCTTTGACGAGGTGGAAAAAGCTCATCCTGATATTTTCAATGTGCTTCTTCAAGTCTTAGATGACGGG
GTGCTGACCGACAGCAAGGGACGTAAGGTGGATTTTTCTAATACCATTATCATTATGACCAGCAATCTTGGTGCGACAAG
TTTGCGGGACGATAAGACAGTCGGTTTTGGAGCGCGTGATGCCCGCTTTGATCATGAAAACATGGAAAAACGGATGATGG
AAGAGCTCAAGAAAAGTTATCGTCCGGAATTTATCAACCGGATTGATGAAAAGGTTGTTTTCCATAGCCTGACTAGCGAA
GACATGCAAGAAGTGGTAAAAATTATGGTGAAACCACTCATTGTCAGTCTCGCTGAAAAAGGAATTGAGCTGAAATTCCA
ACCTAGTGCTTTGAAACTTCTGGCTAAAAAAGGTTACGATCCTGAAATGGGAGCAAGGCCACTTCGCAGAACCCTACAAA
CTCAGGTGGAAGACCATTTATCAGAATTACTTTTAGCAGGTGAGCTAAAAACGGGACAAAGCTTGAAAGTCGGTGTCAAG
GCTGGGCAGCTGAAGTTTGAAGTGCTATGA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (371-439)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (717-797)

• AAA domain (Cdc48 subfamily) (AAA_2) (539-710)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-60)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (91-130)

• ATPase family associated with various cellular activities (AAA) (AAA) (231-347)

3D structure

• AlphaFold DB: A0A7L8W337

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	77.682	100	0.779
clpC	Streptococcus pneumoniae D39	77.682	100	0.779
clpC	Streptococcus pneumoniae TIGR4	77.682	100	0.779
clpC	Streptococcus mutans UA159	66.626	100	0.671
clpC	Streptococcus thermophilus LMG 18311	66.093	100	0.665
clpC	Streptococcus thermophilus LMD-9	65.971	100	0.664
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.88	100	0.512
clpC	Bacillus subtilis subsp. subtilis str. 168	44.583	99.258	0.443
clpE	Streptococcus pneumoniae Rx1	47.284	77.379	0.366
clpE	Streptococcus pneumoniae D39	47.284	77.379	0.366
clpE	Streptococcus pneumoniae R6	47.284	77.379	0.366
clpE	Streptococcus pneumoniae TIGR4	47.284	77.379	0.366
clpC	Lactococcus lactis subsp. cremoris KW2	44.31	81.459	0.361
clpE	Streptococcus mutans UA159	47.021	76.761	0.361