Detailed information NTG0374538

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: G8B42_RS08935
• Genome accession: NZ_CP049690
• Coordinates: 1806272..1808827 (-)
• Length: 851 a.a.
• NCBI ID: WP_011529121.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain ABC208
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1801272..1813827

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B42_RS08890 (G8B42_08970)	-	1801658..1802305 (-)	648	WP_011529101.1	helix-turn-helix transcriptional regulator	-
G8B42_RS08895 (G8B42_08975)	-	1802471..1802668 (+)	198	WP_011529102.1	helix-turn-helix transcriptional regulator	-
G8B42_RS08900 (G8B42_08980)	-	1802682..1803296 (+)	615	WP_021299093.1	Bro-N domain-containing protein	-
G8B42_RS08905 (G8B42_08985)	-	1803323..1803559 (+)	237	Protein_1704	phage antirepressor protein	-
G8B42_RS08910 (G8B42_08990)	-	1803751..1804164 (+)	414	WP_012560493.1	DUF1492 domain-containing protein	-
G8B42_RS08915 (G8B42_08995)	-	1804239..1804439 (+)	201	WP_011529120.1	hypothetical protein	-
G8B42_RS08920 (G8B42_09000)	-	1804506..1804700 (+)	195	Protein_1707	DUF1492 domain-containing protein	-
G8B42_RS08925 (G8B42_09005)	-	1804675..1805058 (+)	384	WP_011285285.1	ArpU family phage packaging/lysis transcriptional regulator	-
G8B42_RS08930 (G8B42_09010)	-	1805259..1805876 (+)	618	WP_021340716.1	hypothetical protein	-
G8B42_RS08935 (G8B42_09015)	hexA	1806272..1808827 (-)	2556	WP_011529121.1	DNA mismatch repair protein MutS	Machinery gene
G8B42_RS09495 (G8B42_09020)	-	1808814..1809166 (-)	353	Protein_1711	YlbF family regulator	-
G8B42_RS08945 (G8B42_09025)	argR	1809163..1809600 (-)	438	WP_002982171.1	arginine repressor	-
G8B42_RS08950 (G8B42_09030)	argS	1809891..1811582 (+)	1692	WP_011529123.1	arginine--tRNA ligase	-
G8B42_RS08955 (G8B42_09035)	-	1811670..1811978 (+)	309	WP_012561077.1	bacteriocin immunity protein	-
G8B42_RS08960 (G8B42_09040)	-	1812005..1812877 (-)	873	WP_011529124.1	YitT family protein	-
G8B42_RS08965 (G8B42_09045)	-	1812920..1813798 (-)	879	WP_021299113.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95518.08 Da
• Isoelectric Point: 5.0199

>NTDB_id=374538 G8B42_RS08935 WP_011529121.1 1806272..1808827(-) (hexA) [Streptococcus pyogenes strain ABC208]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAIDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSAYVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=374538 G8B42_RS08935 WP_011529121.1 1806272..1808827(-) (hexA) [Streptococcus pyogenes strain ABC208]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTATTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTGTCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGTCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAAATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTCTAGATTTGGTAGAGAATGCTAG
AACGAATAAAAAACATGGGAGTCTGTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACAGATTTAAGCAATAGCTTAAAAGGTGTTTACGATATCGAACGCTTATCTAGCCGTGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCCATATTAGAGTCTTTTAACA
GCGCTTATGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTAAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGACCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATGTCAGTCCCTCCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAATATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.563	100	0.716
mutS	Pseudomonas stutzeri strain ATCC 17587	36.959	100	0.371