Detailed information NTG0037405

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SARLGA251_RS12880
• Genome accession: NC_017349
• Coordinates: 2564518..2566626 (+)
• Length: 702 a.a.
• NCBI ID: WP_001063333.1
• Uniprot ID: -
• Organism: Staphylococcus aureus subsp. aureus LGA251
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2559518..2571626

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SARLGA251_RS12855 (SARLGA251_23180)	-	2559582..2559800 (+)	219	WP_000011686.1	sterile alpha motif-like domain-containing protein	-
SARLGA251_RS12860 (SARLGA251_23190)	-	2560190..2560621 (+)	432	WP_000455861.1	CHAP domain-containing protein	-
SARLGA251_RS12865 (SARLGA251_23200)	-	2560762..2562042 (-)	1281	WP_001191009.1	hydroxymethylglutaryl-CoA reductase, degradative	-
SARLGA251_RS12870 (SARLGA251_23210)	-	2562297..2563463 (+)	1167	WP_000151980.1	hydroxymethylglutaryl-CoA synthase	-
SARLGA251_RS12875 (SARLGA251_23220)	-	2563634..2564155 (-)	522	WP_000262603.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
SARLGA251_RS12880 (SARLGA251_23230)	clpE	2564518..2566626 (+)	2109	WP_001063333.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
SARLGA251_RS12885 (SARLGA251_23240)	-	2566693..2566863 (-)	171	WP_000022349.1	FeoB-associated Cys-rich membrane protein	-
SARLGA251_RS12890 (SARLGA251_23250)	feoB	2566876..2568870 (-)	1995	WP_000432887.1	ferrous iron transport protein B	-
SARLGA251_RS12895 (SARLGA251_23260)	-	2568882..2569109 (-)	228	WP_000932075.1	FeoA family protein	-

Sequence

Protein

• Length: 702 a.a.
• Molecular weight: 78093.65 Da
• Isoelectric Point: 4.7151

>NTDB_id=37405 SARLGA251_RS12880 WP_001063333.1 2564518..2566626(+) (clpE) [Staphylococcus aureus subsp. aureus LGA251]
MNNNFFNSDFDSILRRMMQDMQNSNQTSNKKYYINGKEVSPEELAQFTQQGGNHSAEQSAQAFQQAALRQQGQQSGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISI
DISSLEAGTQYRGAFEENIQKLVEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNIMKDAALTRRFNEVLVNEPSARDTVEILKGIREKFETHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAIDKVATEKRISELEHDKRKAVSAEEYKKADGIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDANDIERLKNISSRLRSKIIGQDKAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKEA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGTDQEYDDIMQEMKKFFRPEFLNRFNGIVEFLHLDKESLQEIINLLLDDVQVTLDKKGITMNV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDLDIEDNELVVKGKS

Nucleotide

• Length: 2109 bp

>NTDB_id=37405 SARLGA251_RS12880 WP_001063333.1 2564518..2566626(+) (clpE) [Staphylococcus aureus subsp. aureus LGA251]
ATGAATAACAATTTTTTCAATAGTGACTTCGATTCTATTTTGCGAAGAATGATGCAAGACATGCAAAACTCAAATCAGAC
TAGTAACAAGAAATACTATATTAATGGTAAAGAAGTTTCACCGGAAGAATTAGCACAATTTACGCAACAAGGTGGTAATC
ATTCTGCCGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACTAAGACAACAAGGTCAACAAAGTGGCAATGGCAATTAT
CTAGAACAAATTGGTCGTAACTTAACGCAAGAGGCTCGTGATGGATTATTAGATCCAGTCATCGGTCGTGATAAAGAAAT
CCAAGAAACTGCAGAAGTCTTAAGTAGACGCACTAAAAACAATCCTATCCTAGTCGGAGAAGCTGGAGTTGGTAAAACTG
CGATTGTCGAAGGTTTAGCGCAAGCAATCGTTGAAGGGAACGTACCTGCAGCAATCAAAGATAAAGAAATTATATCTATA
GATATTTCATCGCTTGAAGCTGGAACGCAATATCGTGGCGCCTTTGAAGAAAACATCCAAAAGTTAGTTGAAGGCGTTAA
ATCATCACAAAATGCTGTGCTCTTCTTTGACGAAATTCACCAAATCATCGGTTCCGGCGCAACAGGAAGTGATTCCGGTA
GTAAAGGGTTATCTGATATTTTAAAACCAGCATTAAGTCGTGGTGAAATTTCAATTATAGGTGCAACAACTCAAGATGAA
TATCGCAATAATATCATGAAAGACGCTGCATTAACACGTCGTTTTAACGAGGTACTGGTTAACGAACCAAGCGCAAGAGA
TACGGTTGAAATTTTAAAAGGAATTCGCGAAAAATTTGAAACACACCATCAAGTCAAATTACCTGATGACGTATTAAAGG
CATGTGTAGACTTATCCATTCAATATATTCCACAACGCTTATTACCTGACAAAGCAATCGATGTATTAGATATTACAGCT
GCACATTTATCTGCACAAAGCCCTGCTATTGATAAAGTCGCGACTGAAAAACGTATTTCTGAATTGGAACATGATAAGCG
TAAAGCTGTAAGTGCTGAAGAATATAAAAAAGCAGATGGCATTCAAAATGAAATCAAATCTCTACAAGATAAATTAGAAA
ACAGTAATGGTGAACATACTGCAGTAGCAACGGTGCATGATATTTCTGATACCATTCAACGATTAACTGGTATTCCTGTA
TCTCAAATGGATGCCAATGACATTGAACGTTTAAAAAATATTTCTAGTCGTTTAAGAAGTAAAATCATCGGTCAAGATAA
AGCTGTAGAAATGGTTTCTCGTGCCATTCGTCGTAATCGAGCTGGTTTTGATGATGGCAATCGTCCAATTGGTAGCTTCC
TATTTGTCGGTCCTACTGGTGTTGGTAAAACAGAGCTTGCCAAACAGTTAGCCATTGATTTATTTGGTAATAAAGAAGCA
CTGATTCGACTTGATATGAGTGAATATAGTGATACTACTGCTGTTTCTAAAATGATTGGTACAACTGCTGGTTATGTCGG
TTATGACGATAATTCAAATACATTAACTGAAAAAGTACGACGCAATCCATATTCAGTCATTCTATTTGATGAAATTGAAA
AGGCTAATCCACAAATATTAACATTATTACTACAAGTGATGGATGATGGTAATTTAACAGATGGTCAAGGTAACGTCATC
AACTTTAAAAACACAATCATTATTTGTACGTCAAACGCTGGTTTTGGTAACGGTACAGACCAAGAATACGATGACATTAT
GCAAGAAATGAAAAAATTCTTCCGCCCTGAATTTCTTAACCGCTTCAATGGTATTGTGGAATTCTTACACCTAGATAAAG
AATCACTACAAGAAATCATTAATTTATTATTGGATGATGTCCAAGTAACATTAGATAAAAAAGGTATTACGATGAATGTC
TCTCAAGATGCAAAAGATTGGTTAATTGAAGAGGGATATGATGAAGAGTTAGGCGCACGCCCATTAAGACGCATTGTTGA
ACAACAAGTGCGTGACAAAATAACAGATTATTATTTAGATCATACAGACGTTAAACATGTGGATTTAGATATCGAAGACA
ACGAATTAGTCGTCAAAGGTAAATCATGA

Domains

Predicted by InterProScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

• AAA lid domain (AAA_lid_9) (265-362)

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-257)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	47.745	91.595	0.437
clpC	Lactococcus lactis subsp. cremoris KW2	46.203	90.028	0.416
clpE	Streptococcus pneumoniae Rx1	47.326	87.892	0.416
clpE	Streptococcus pneumoniae TIGR4	47.326	87.892	0.416
clpE	Streptococcus pneumoniae R6	47.326	87.892	0.416
clpE	Streptococcus pneumoniae D39	47.326	87.892	0.416
clpC	Bacillus subtilis subsp. subtilis str. 168	44.037	93.162	0.41
clpC	Streptococcus thermophilus LMD-9	44.64	89.031	0.397
clpC	Streptococcus thermophilus LMG 18311	44.48	89.031	0.396
clpC	Streptococcus pneumoniae TIGR4	43.78	88.177	0.386
clpC	Streptococcus pneumoniae Rx1	43.78	88.177	0.386
clpC	Streptococcus pneumoniae D39	43.78	88.177	0.386
clpC	Streptococcus mutans UA159	43.902	87.607	0.385
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.215	88.746	0.375