Detailed information NTG0373510

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FO458_RS03270
• Genome accession: NZ_CP041726
• Coordinates: 667823..668866 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain SL118
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 662823..673866

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FO458_RS03245 (FO458_03245)	-	663113..664474 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
FO458_RS03250 (FO458_03250)	-	664608..665588 (-)	981	WP_070648298.1	aromatic acid exporter family protein	-
FO458_RS03255 (FO458_03255)	map	665833..666588 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
FO458_RS03260 (FO458_03260)	-	666714..667100 (+)	387	WP_002477960.1	hypothetical protein	-
FO458_RS03265 (FO458_03265)	liaF	667125..667826 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
FO458_RS03270 (FO458_03270)	vraS	667823..668866 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
FO458_RS03275 (FO458_03275)	vraR	668856..669485 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
FO458_RS03280 (FO458_03280)	-	669658..670887 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
FO458_RS03285 (FO458_03285)	-	671090..671374 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
FO458_RS03290 (FO458_03290)	-	671381..671845 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
FO458_RS03295 (FO458_03295)	-	672009..672194 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
FO458_RS03300 (FO458_03300)	-	672264..673445 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=373510 FO458_RS03270 WP_002461334.1 667823..668866(+) (vraS) [Staphylococcus lugdunensis strain SL118]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=373510 FO458_RS03270 WP_002461334.1 667823..668866(+) (vraS) [Staphylococcus lugdunensis strain SL118]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911