Detailed information NTG0373479

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FO457_RS04415
• Genome accession: NZ_CP041725
• Coordinates: 931287..932330 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain SL117
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 926287..937330

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FO457_RS04390 (FO457_04390)	-	926577..927938 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
FO457_RS04395 (FO457_04395)	-	928072..929052 (-)	981	WP_002477959.1	FUSC family protein	-
FO457_RS04400 (FO457_04400)	map	929297..930052 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
FO457_RS04405 (FO457_04405)	-	930178..930564 (+)	387	WP_002477960.1	hypothetical protein	-
FO457_RS04410 (FO457_04410)	liaF	930589..931290 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
FO457_RS04415 (FO457_04415)	vraS	931287..932330 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
FO457_RS04420 (FO457_04420)	vraR	932320..932949 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
FO457_RS04425 (FO457_04425)	-	933122..934351 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
FO457_RS04430 (FO457_04430)	-	934554..934838 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
FO457_RS04435 (FO457_04435)	-	934845..935309 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
FO457_RS04440 (FO457_04440)	-	935473..935658 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
FO457_RS04445 (FO457_04445)	-	935728..936909 (+)	1182	WP_230454756.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=373479 FO457_RS04415 WP_002461334.1 931287..932330(+) (vraS) [Staphylococcus lugdunensis strain SL117]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=373479 FO457_RS04415 WP_002461334.1 931287..932330(+) (vraS) [Staphylococcus lugdunensis strain SL117]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911