Detailed information NTG0373449

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FO456_RS05885
• Genome accession: NZ_CP041724
• Coordinates: 1266634..1267677 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain SL55
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1261634..1272677

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FO456_RS05860 (FO456_05865)	-	1261924..1263285 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
FO456_RS05865 (FO456_05870)	-	1263419..1264399 (-)	981	WP_070648298.1	aromatic acid exporter family protein	-
FO456_RS05870 (FO456_05875)	map	1264644..1265399 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
FO456_RS05875 (FO456_05880)	-	1265525..1265911 (+)	387	WP_002477960.1	hypothetical protein	-
FO456_RS05880 (FO456_05885)	liaF	1265936..1266637 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
FO456_RS05885 (FO456_05890)	vraS	1266634..1267677 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
FO456_RS05890 (FO456_05895)	vraR	1267667..1268296 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
FO456_RS05895 (FO456_05900)	-	1268469..1269698 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
FO456_RS05900 (FO456_05905)	-	1269901..1270185 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
FO456_RS05905 (FO456_05910)	-	1270192..1270656 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
FO456_RS05910 (FO456_05915)	-	1270820..1271005 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
FO456_RS05915 (FO456_05920)	-	1271075..1272256 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=373449 FO456_RS05885 WP_002461334.1 1266634..1267677(+) (vraS) [Staphylococcus lugdunensis strain SL55]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=373449 FO456_RS05885 WP_002461334.1 1266634..1267677(+) (vraS) [Staphylococcus lugdunensis strain SL55]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911