Detailed information NTG0368588

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FIU13_RS02385
• Genome accession: NZ_CP040997
• Coordinates: 443851..444888 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain FDAARGOS_774
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 438851..449888

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FIU13_RS02365 (FIU13_02365)	-	439601..440227 (+)	627	WP_010922497.1	prepilin peptidase	-
FIU13_RS02370 (FIU13_02370)	rlmN	440309..441388 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FIU13_RS02375 (FIU13_02375)	-	441392..442012 (-)	621	WP_011285637.1	YutD family protein	-
FIU13_RS02380 (FIU13_02380)	-	442460..443437 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
FIU13_RS02385 (FIU13_02385)	sepM	443851..444888 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
FIU13_RS02390 (FIU13_02390)	coaD	444875..445366 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
FIU13_RS02395 (FIU13_02395)	rsmD	445356..445895 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FIU13_RS02400 (FIU13_02400)	asnA	446018..447010 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
FIU13_RS02405 (FIU13_02405)	arcC	447323..448273 (-)	951	WP_010922501.1	carbamate kinase	-
FIU13_RS02410 (FIU13_02410)	-	448293..449624 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=368588 FIU13_RS02385 WP_010922499.1 443851..444888(-) (sepM) [Streptococcus pyogenes strain FDAARGOS_774]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=368588 FIU13_RS02385 WP_010922499.1 443851..444888(-) (sepM) [Streptococcus pyogenes strain FDAARGOS_774]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693