Detailed information NTG0036617

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SMUNN2025_RS09095
• Genome accession: NC_013928
• Coordinates: 1861372..1863813 (-)
• Length: 813 a.a.
• NCBI ID: WP_002287727.1
• Uniprot ID: -
• Organism: Streptococcus mutans NN2025
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1856372..1868813

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUNN2025_RS09080 (SmuNN2025_1764)	rpsJ	1857194..1857502 (-)	309	WP_002262341.1	30S ribosomal protein S10	-
SMUNN2025_RS09085 (SmuNN2025_1765)	-	1857822..1858508 (+)	687	WP_002266894.1	helix-turn-helix domain-containing protein	-
SMUNN2025_RS09090 (SmuNN2025_1766)	-	1858699..1861086 (-)	2388	WP_012997960.1	glycoside hydrolase family 68 protein	-
SMUNN2025_RS09095 (SmuNN2025_1767)	clpC	1861372..1863813 (-)	2442	WP_002287727.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SMUNN2025_RS09100 (SmuNN2025_1768)	ctsR	1863810..1864274 (-)	465	WP_002277504.1	transcriptional regulator CtsR	-
SMUNN2025_RS09105 (SmuNN2025_1769)	-	1864548..1864910 (+)	363	WP_226707807.1	COG2426 family protein	-
SMUNN2025_RS09110 (SmuNN2025_1770)	-	1865116..1866912 (-)	1797	WP_002277502.1	DHA2 family efflux MFS transporter permease subunit	-
SMUNN2025_RS09115 (SmuNN2025_1771)	-	1867091..1867633 (+)	543	WP_002277501.1	TetR/AcrR family transcriptional regulator	-
SMUNN2025_RS09120 (SmuNN2025_1772)	-	1867775..1868317 (-)	543	WP_002277500.1	TetR/AcrR family transcriptional regulator	-

Sequence

Protein

• Length: 813 a.a.
• Molecular weight: 90449.25 Da
• Isoelectric Point: 7.0221

>NTDB_id=36617 SMUNN2025_RS09095 WP_002287727.1 1861372..1863813(-) (clpC) [Streptococcus mutans NN2025]
MTDYSLKMQEVFRLAQFEAARFESSYLESWHVLLAMVEIDSSVAGLSFAEFEADVRFEDYQAAAILAIGKKPKSSSNDIM
LLEQSHALKRTLAEAAAISQVTHAKEVGTEHVLFAMLLNPNLLATRILELVGFHAKDDGESIRLLDLRKVIERYAGFSKE
DIKAIFEMRKPKKVKNSSSFSDLMKPPSVTGELADFTRDLTELARQGRLEPVIGREQEISRMVQILSRKTKNNPVLVGDA
GVGKTALAYGLAQRIVDSAVPFELADMKVLELDMMSVVAGTRFRGDFEERMNQIIADIEADGHIVLFIDELHTIMGSGSG
IDSTLDAANILKPALARGSLRTIGATTQEEYQKHIEKDAALSRRFAKVTIEEPSEEEAYQILFGLKKSYETYHHVIISDA
AVMAAVKGAHRYLSGKNLPDSAIDLLDEASATVQGLVKKKAPAYLTDLDHALITNDYQLAKRLLKKEKKPLLKKRAEVKE
EDILATLSKLSGIPVKKLTQADSKKYLNLERELHKRVIGQDDAVSSISRAIRRNQSGIRVGKRPIGSFMFLGPTGVGKTE
LAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNILLQV
LDDGVLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKSFSQDYKAMESRILEELKKVYRPEFINRIDEKVVFHN
LGQEDIRHVVKIMVAPLIAHLADQGITLKFQPSALKHLALAGYDAEMGARPLRRTLQTEVEDKLAELILSRKLASGQTLK
IGIQKEKLKFDIV

Nucleotide

• Length: 2442 bp

>NTDB_id=36617 SMUNN2025_RS09095 WP_002287727.1 1861372..1863813(-) (clpC) [Streptococcus mutans NN2025]
ATGACCGATTACTCATTAAAAATGCAGGAAGTCTTTCGATTGGCGCAATTTGAAGCAGCTCGTTTTGAAAGTTCCTATTT
AGAAAGCTGGCATGTCCTTCTTGCAATGGTAGAGATTGATTCCTCAGTGGCTGGTTTAAGTTTTGCGGAGTTTGAAGCAG
ATGTCCGTTTTGAGGATTATCAGGCTGCTGCTATTTTGGCGATTGGTAAAAAGCCTAAGTCCTCGAGTAATGATATTATG
CTTTTAGAGCAATCACATGCTTTAAAACGAACCCTAGCAGAGGCCGCTGCTATTAGTCAGGTGACACACGCTAAAGAAGT
CGGCACAGAACATGTTCTCTTTGCTATGTTACTGAATCCTAATCTTTTGGCGACTCGCATTTTAGAATTAGTTGGTTTTC
ACGCCAAAGATGATGGAGAGTCTATCCGTCTTTTGGATCTGCGAAAAGTGATTGAACGTTATGCTGGCTTTTCCAAAGAG
GACATTAAGGCCATCTTTGAAATGCGTAAACCTAAAAAGGTCAAAAATAGCAGCAGCTTTTCTGATTTAATGAAGCCACC
TAGCGTTACAGGTGAACTAGCTGATTTTACACGGGATTTGACGGAGTTGGCAAGACAAGGTCGTTTAGAACCTGTTATTG
GCCGTGAACAAGAAATTTCACGGATGGTTCAAATTTTAAGCCGTAAGACAAAAAATAACCCTGTTTTAGTTGGCGATGCT
GGTGTTGGGAAGACGGCTTTAGCTTATGGCCTTGCTCAACGTATTGTGGATAGTGCCGTTCCTTTTGAATTGGCAGATAT
GAAAGTACTAGAGCTCGATATGATGAGTGTTGTTGCAGGAACTCGTTTTCGTGGCGATTTTGAGGAACGAATGAATCAAA
TTATTGCAGACATTGAAGCTGATGGTCACATTGTCCTCTTCATTGATGAGCTGCATACCATTATGGGTTCAGGAAGTGGT
ATTGATAGTACGCTGGATGCTGCTAATATTCTTAAACCAGCTTTAGCGCGCGGCAGTCTTAGAACGATTGGAGCGACTAC
TCAAGAGGAGTATCAAAAGCATATTGAAAAAGATGCTGCTCTTTCTCGCCGTTTTGCTAAGGTAACTATTGAAGAACCAA
GTGAAGAAGAAGCTTATCAGATCTTGTTTGGTTTAAAGAAAAGTTATGAAACTTATCATCATGTTATTATTTCTGATGCA
GCCGTAATGGCGGCAGTCAAAGGAGCACATCGTTATTTAAGTGGTAAAAATTTACCTGATTCGGCTATCGATCTTTTAGA
TGAAGCTAGTGCAACTGTTCAAGGCTTAGTGAAAAAAAAGGCACCAGCTTATTTGACAGATTTAGATCATGCTCTTATCA
CTAACGATTACCAATTAGCTAAGCGTTTGCTGAAAAAGGAGAAGAAACCTCTGCTTAAAAAACGAGCTGAAGTCAAGGAA
GAAGATATCCTAGCTACTCTCAGCAAACTTTCGGGCATCCCTGTCAAAAAATTAACACAGGCTGACAGTAAAAAGTACCT
TAATCTCGAAAGGGAATTACATAAGCGTGTAATTGGTCAAGACGATGCGGTGTCCAGTATCAGCCGTGCTATTCGCCGCA
ATCAATCCGGAATTCGGGTTGGCAAACGTCCCATTGGCTCTTTCATGTTTTTGGGGCCGACAGGTGTTGGTAAAACAGAG
CTTGCTAAGGCTTTGGCAGAAGTGCTTTTTGATGATGAGTCAGCTCTTATTCGTTTTGACATGAGCGAATATATGGAAAA
ATTTGCAGCTTCTCGCCTTAATGGAGCTCCTCCGGGTTATGTGGGGTATGAAGAAGGCGGTGAGTTGACGGAAAAGGTTC
GTAACAAACCTTACTCTGTTCTTCTTTTTGATGAGGTGGAAAAAGCTCATCCAGATATTTTCAATATCTTACTTCAAGTA
CTTGATGATGGTGTTTTGACAGATAGCCGTGGTCGCAAAGTTGATTTTTCAAATACGATTATTATCATGACCTCTAATTT
GGGTGCGACTGCGCTTCGTGATGATAAAACCGTTGGTTTTGGAGCTAAAAGCTTTTCCCAGGATTATAAGGCCATGGAAA
GTCGTATTTTAGAGGAATTAAAAAAGGTTTACCGACCTGAATTTATTAATCGTATTGATGAAAAAGTTGTCTTTCATAAC
CTTGGTCAAGAAGACATACGCCATGTTGTTAAAATTATGGTTGCTCCATTGATTGCCCATTTGGCTGATCAGGGGATTAC
ACTTAAGTTTCAGCCTTCAGCTTTGAAACATTTAGCTCTGGCAGGTTATGATGCTGAAATGGGGGCACGTCCTTTGCGTC
GGACACTTCAGACAGAAGTGGAAGATAAGTTAGCAGAGCTTATTCTTTCGAGGAAACTAGCCAGTGGACAGACTCTGAAA
ATAGGTATTCAAAAAGAAAAATTAAAATTTGATATTGTATAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (721-801)

• AAA lid domain (AAA_lid_9) (374-461)

• AAA domain (Cdc48 subfamily) (AAA_2) (543-714)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (105-133)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (15-55)

• ATPase family associated with various cellular activities (AAA) (AAA) (235-366)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	99.631	100	0.996
clpC	Streptococcus thermophilus LMD-9	72.304	100	0.726
clpC	Streptococcus thermophilus LMG 18311	72.181	100	0.724
clpC	Streptococcus pneumoniae TIGR4	66.953	100	0.67
clpC	Streptococcus pneumoniae Rx1	66.953	100	0.67
clpC	Streptococcus pneumoniae D39	66.953	100	0.67
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.86	100	0.501
clpC	Bacillus subtilis subsp. subtilis str. 168	43.584	100	0.443
clpE	Streptococcus pneumoniae TIGR4	47.2	76.876	0.363
clpE	Streptococcus pneumoniae Rx1	47.2	76.876	0.363
clpE	Streptococcus pneumoniae D39	47.2	76.876	0.363
clpE	Streptococcus pneumoniae R6	47.2	76.876	0.363
clpE	Streptococcus mutans UA159	47.04	76.876	0.362