Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   SMUNN2025_RS06900 Genome accession   NC_013928
Coordinates   1416840..1418639 (-) Length   599 a.a.
NCBI ID   WP_002283195.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1398676..1463107 1416840..1418639 within 0


Gene organization within MGE regions


Location: 1398676..1463107
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS06815 (SmuNN2025_1326) argB 1399017..1399754 (-) 738 WP_002277924.1 acetylglutamate kinase -
  SMUNN2025_RS06820 (SmuNN2025_1327) argJ 1399783..1400976 (-) 1194 WP_012997863.1 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase -
  SMUNN2025_RS06825 (SmuNN2025_1328) argC 1401135..1402157 (-) 1023 WP_002272601.1 N-acetyl-gamma-glutamyl-phosphate reductase -
  SMUNN2025_RS06830 (SmuNN2025_1329) - 1402292..1402981 (-) 690 WP_002272600.1 CPBP family intramembrane glutamic endopeptidase -
  SMUNN2025_RS06835 (SmuNN2025_1330) - 1403126..1403371 (-) 246 WP_002261880.1 helix-turn-helix transcriptional regulator -
  SMUNN2025_RS06840 (SmuNN2025_1331) - 1403675..1405057 (-) 1383 WP_041160321.1 sensor histidine kinase -
  SMUNN2025_RS06845 (SmuNN2025_1332) - 1405048..1405707 (-) 660 WP_002261882.1 response regulator transcription factor -
  SMUNN2025_RS06850 (SmuNN2025_1333) - 1405747..1406586 (-) 840 WP_002277929.1 TraX family protein -
  SMUNN2025_RS06855 (SmuNN2025_1334) - 1406962..1407396 (-) 435 Protein_1326 lantibiotic immunity ABC transporter MutG family permease subunit -
  SMUNN2025_RS06860 (SmuNN2025_1335) - 1407616..1408602 (+) 987 WP_002292450.1 ABC transporter permease -
  SMUNN2025_RS06865 (SmuNN2025_1336) - 1408596..1409345 (+) 750 WP_002264195.1 ABC transporter ATP-binding protein -
  SMUNN2025_RS06870 (SmuNN2025_1337) - 1409365..1410402 (+) 1038 WP_012997865.1 ABC transporter substrate-binding protein -
  SMUNN2025_RS06875 (SmuNN2025_1338) alaS 1410614..1413232 (-) 2619 WP_012997866.1 alanine--tRNA ligase -
  SMUNN2025_RS06880 (SmuNN2025_1339) - 1413447..1413947 (-) 501 WP_002265403.1 LURP-one-related/scramblase family protein -
  SMUNN2025_RS06885 (SmuNN2025_1340) prsA 1414186..1415187 (-) 1002 WP_002275165.1 peptidylprolyl isomerase PrsA -
  SMUNN2025_RS06890 (SmuNN2025_1341) - 1415249..1415956 (-) 708 WP_002273046.1 O-methyltransferase -
  SMUNN2025_RS06895 (SmuNN2025_1342) - 1416006..1416623 (-) 618 WP_002283196.1 HAD-IA family hydrolase -
  SMUNN2025_RS06900 (SmuNN2025_1343) pepF 1416840..1418639 (-) 1800 WP_002283195.1 oligoendopeptidase F Regulator
  SMUNN2025_RS06905 (SmuNN2025_1344) - 1418651..1419598 (-) 948 WP_002277935.1 competence protein CoiA -
  SMUNN2025_RS06910 (SmuNN2025_1345) - 1419904..1420797 (-) 894 WP_002271023.1 alpha/beta hydrolase -
  SMUNN2025_RS10365 - 1420903..1421184 (-) 282 Protein_1338 hypothetical protein -
  SMUNN2025_RS10370 - 1421269..1421396 (+) 128 Protein_1339 ArsR/SmtB family transcription factor -
  SMUNN2025_RS06915 (SmuNN2025_1346) - 1421429..1422397 (-) 969 WP_002277936.1 alcohol dehydrogenase catalytic domain-containing protein -
  SMUNN2025_RS06920 (SmuNN2025_1347) - 1422525..1423898 (+) 1374 WP_002277937.1 PLP-dependent aminotransferase family protein -
  SMUNN2025_RS06925 (SmuNN2025_1348) - 1423988..1424488 (-) 501 WP_002277938.1 GNAT family N-acetyltransferase -
  SMUNN2025_RS06930 (SmuNN2025_1349) - 1424503..1425219 (-) 717 WP_002267115.1 pseudouridine synthase -
  SMUNN2025_RS10755 - 1425365..1426008 (+) 644 Protein_1344 glutathione S-transferase C-terminal domain-containing protein -
  SMUNN2025_RS06940 (SmuNN2025_1351) nagB 1426237..1426938 (-) 702 WP_002265393.1 glucosamine-6-phosphate deaminase NagB -
  SMUNN2025_RS06945 (SmuNN2025_1352) - 1427069..1427788 (-) 720 WP_002261906.1 VIT family protein -
  SMUNN2025_RS06950 (SmuNN2025_1353) queA 1427926..1428954 (+) 1029 WP_012997868.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  SMUNN2025_RS06955 (SmuNN2025_1354) - 1429141..1430370 (-) 1230 WP_002283192.1 acyl-CoA thioesterase/bile acid-CoA:amino acid N-acyltransferase family protein -
  SMUNN2025_RS06960 (SmuNN2025_1355) - 1430417..1430881 (-) 465 WP_012997869.1 MarR family transcriptional regulator -
  SMUNN2025_RS06965 (SmuNN2025_1356) - 1430950..1431708 (-) 759 WP_002272070.1 YhfC family intramembrane metalloprotease -
  SMUNN2025_RS10150 (SmuNN2025_1357) - 1431873..1432937 (-) 1065 WP_079993445.1 serine hydrolase -
  SMUNN2025_RS06975 (SmuNN2025_1358) sodA 1433490..1434101 (-) 612 WP_041160327.1 superoxide dismutase SodA -
  SMUNN2025_RS06980 (SmuNN2025_1359) holA 1434248..1435288 (-) 1041 WP_002281296.1 DNA polymerase III subunit delta -
  SMUNN2025_RS06995 (SmuNN2025_1362) - 1436895..1437521 (-) 627 WP_002292456.1 DUF805 domain-containing protein -
  SMUNN2025_RS07000 (SmuNN2025_1363) comEC/celB 1437707..1439941 (-) 2235 WP_002292457.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  SMUNN2025_RS07005 (SmuNN2025_1364) - 1439931..1440611 (-) 681 WP_012997873.1 helix-hairpin-helix domain-containing protein -
  SMUNN2025_RS07010 (SmuNN2025_1365) - 1440750..1441502 (-) 753 WP_002264733.1 lysophospholipid acyltransferase family protein -
  SMUNN2025_RS07015 (SmuNN2025_1366) - 1441641..1442576 (+) 936 WP_012997875.1 polysaccharide deacetylase family protein -
  SMUNN2025_RS07020 (SmuNN2025_1367) - 1442665..1443177 (+) 513 WP_002265382.1 HXXEE domain-containing protein -
  SMUNN2025_RS07025 (SmuNN2025_1368) - 1443223..1444242 (+) 1020 WP_002280666.1 GIY-YIG nuclease family protein -
  SMUNN2025_RS07030 (SmuNN2025_1369) - 1445257..1445616 (-) 360 WP_002263746.1 hypothetical protein -
  SMUNN2025_RS07035 (SmuNN2025_1370) - 1445660..1445908 (-) 249 WP_002278069.1 hypothetical protein -
  SMUNN2025_RS07040 (SmuNN2025_1371) - 1446337..1447890 (-) 1554 WP_002278068.1 DEAD/DEAH box helicase -
  SMUNN2025_RS07045 (SmuNN2025_1372) spaP 1448180..1452880 (-) 4701 WP_012997877.1 cell surface antigen I/II -
  SMUNN2025_RS07050 (SmuNN2025_1373) - 1453118..1454953 (-) 1836 WP_002311536.1 SH3 domain-containing protein -
  SMUNN2025_RS07055 (SmuNN2025_1374) - 1455207..1456751 (-) 1545 WP_002277863.1 peptide chain release factor 3 -
  SMUNN2025_RS07060 (SmuNN2025_1375) - 1456935..1457618 (-) 684 WP_002265798.1 TIGR02206 family membrane protein -
  SMUNN2025_RS07065 (SmuNN2025_1376) - 1457730..1459088 (-) 1359 WP_002298318.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  SMUNN2025_RS07070 (SmuNN2025_1377) - 1459166..1460116 (-) 951 WP_002264646.1 bile acid:sodium symporter family protein -
  SMUNN2025_RS07075 (SmuNN2025_1378) - 1460469..1461029 (+) 561 WP_002265800.1 folate family ECF transporter S component -
  SMUNN2025_RS07080 (SmuNN2025_1379) - 1461201..1462250 (-) 1050 WP_002272953.1 D-alanine--D-alanine ligase -
  SMUNN2025_RS07085 (SmuNN2025_1380) recR 1462462..1463061 (-) 600 WP_002264648.1 recombination mediator RecR -

Sequence

Protein


Download         Length: 599 a.a.        Molecular weight: 69738.24 Da        Isoelectric Point: 4.7126

>NTDB_id=36600 SMUNN2025_RS06900 WP_002283195.1 1416840..1418639(-) (pepF) [Streptococcus mutans NN2025]
MSDNRSHIEEKYQWDLTSIFPNDQTWEKEEKSLAKDLGIAVKRADHLLDSSQSLLEITELYLALSRRLEKLYVYASMKND
QDTTVSYYQELQAKATALIAKFNQTFAFYEPEFMLLSTEKYQDFLADCPDLLPYQHFFERLFKQKKHVLSQKEEALLAEA
SEIFGAAGETFEILDNADIIFPWVKDETGEEVELSHGNFISLMESKNRKVRQEAYKAMYSIYEQYQHTYAKTLQTNVKVN
NFQAKIRNYKSAREAALAANFIPETVYDTLVEAVHNHLPLLQRYVKLRQNVLGLDDLKMYDIYVPLSEMDMTFTYEAALD
KAEEVLAIFGRDYAERVHRAFRERWIDVRVNKGKRSGAYSGGSYDTNAFILLNWQDTLDNLFTLVHETGHSLHSTFTREN
QPYVYGDYSIFLAEIASTTNENILTETLLKEATDEKQRFAILNHYLDGFKGTVFRQTQFAEFEDLIYKADQAGDVLTSDY
LNNLYADLNEKYYGLSKENNPEIQYEWARIPHFYYNFYVYQYATGFAAASFLAHKIVHGNQEDKDKYLNYLKAGNSDYPL
NVIAKAGLDMTESTYIDQAFKVFEERLIELEELVEKGID

Nucleotide


Download         Length: 1800 bp        

>NTDB_id=36600 SMUNN2025_RS06900 WP_002283195.1 1416840..1418639(-) (pepF) [Streptococcus mutans NN2025]
ATGTCTGATAATCGCAGTCATATTGAAGAAAAATACCAATGGGATTTGACCAGCATTTTTCCAAACGATCAAACTTGGGA
AAAAGAGGAGAAATCTTTAGCTAAGGATTTGGGAATAGCCGTTAAAAGAGCAGATCATCTGCTTGACTCCAGTCAAAGTC
TGCTGGAGATCACAGAACTTTATCTGGCTTTGAGCCGTCGTTTGGAAAAACTTTATGTTTATGCTTCTATGAAGAATGAC
CAAGACACCACGGTCAGTTACTATCAAGAATTACAAGCTAAGGCAACAGCCTTGATCGCTAAATTTAATCAGACTTTTGC
CTTCTATGAGCCTGAATTTATGCTGTTATCAACAGAAAAATATCAGGATTTTTTGGCAGATTGTCCGGATTTATTGCCTT
ATCAACATTTTTTTGAAAGATTATTCAAACAAAAAAAGCATGTTCTTTCTCAAAAGGAAGAGGCACTTTTGGCTGAAGCC
AGTGAAATTTTTGGTGCTGCTGGTGAAACCTTTGAAATTCTTGACAATGCCGATATTATCTTTCCTTGGGTAAAAGACGA
GACAGGAGAAGAAGTTGAACTATCTCATGGTAATTTCATCAGTTTGATGGAATCCAAAAACCGCAAAGTTCGACAAGAAG
CTTATAAGGCCATGTACAGCATTTATGAGCAGTATCAACACACCTATGCTAAAACGCTGCAAACCAATGTTAAAGTTAAT
AATTTTCAAGCGAAAATCAGAAACTATAAGAGTGCGCGTGAAGCTGCTCTGGCAGCTAATTTTATTCCCGAAACTGTTTA
TGACACTTTAGTAGAAGCGGTCCATAATCACTTACCTTTGTTACAGCGTTATGTGAAGCTAAGGCAAAACGTTTTAGGCC
TTGATGATCTTAAGATGTATGATATTTACGTACCACTCTCAGAAATGGATATGACTTTTACTTATGAAGCAGCCTTGGAC
AAAGCAGAAGAAGTGTTAGCTATTTTTGGGCGAGACTATGCTGAGCGTGTGCATCGTGCATTTAGGGAGCGTTGGATTGA
TGTACGAGTCAATAAAGGCAAGCGTTCAGGCGCTTATTCAGGTGGTTCCTATGACACCAATGCTTTTATATTGCTTAACT
GGCAGGATACTTTGGATAACCTCTTCACTCTTGTGCATGAAACAGGACATTCTCTGCATTCTACTTTTACACGTGAAAAC
CAACCCTATGTTTATGGTGATTATTCTATTTTTCTGGCAGAAATTGCTTCGACAACCAATGAAAATATTTTGACAGAGAC
ACTGCTCAAGGAAGCAACAGATGAGAAACAGCGTTTTGCGATTTTGAATCATTATCTTGATGGTTTCAAAGGAACGGTTT
TCCGCCAAACACAATTTGCAGAATTTGAAGACTTGATTTATAAGGCTGATCAAGCAGGTGACGTTTTGACCAGTGATTAT
TTGAATAATCTCTATGCGGATCTCAATGAAAAATACTATGGTTTAAGTAAGGAAAATAATCCGGAAATTCAGTATGAATG
GGCTAGGATTCCGCATTTCTATTACAATTTTTATGTTTATCAGTACGCCACAGGCTTTGCTGCAGCTAGTTTTTTGGCTC
ACAAAATTGTTCATGGCAATCAAGAAGATAAGGACAAATATCTCAATTATCTCAAAGCTGGCAATTCAGACTATCCTCTC
AATGTTATTGCTAAAGCAGGTCTTGATATGACTGAGTCGACCTATATTGACCAAGCCTTCAAAGTCTTTGAAGAACGGTT
AATAGAGTTGGAAGAGTTGGTCGAAAAAGGAATTGATTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

69.398

99.833

0.693

Multiple sequence alignment