Detailed information
Bioinformatically predicted
Overview
| Name | vraR | Type | Regulator |
| Locus tag | FF958_RS10525 | Genome accession | NZ_CP040622 |
| Coordinates | 2066196..2066825 (-) | Length | 209 a.a. |
| NCBI ID | WP_000153530.1 | Uniprot ID | D9IFM7 |
| Organism | Staphylococcus aureus strain JKD6004 | ||
| Function | repress expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2058907..2100776 | 2066196..2066825 | within | 0 |
Gene organization within MGE regions
Location: 2058907..2100776
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF958_RS10485 (FF958_10485) | - | 2059117..2060163 (+) | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| FF958_RS10490 (FF958_10490) | yfkAB | 2060208..2061353 (+) | 1146 | WP_001245448.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| FF958_RS10495 (FF958_10495) | - | 2061613..2062143 (-) | 531 | WP_095344333.1 | acyl-CoA thioesterase | - |
| FF958_RS10500 (FF958_10500) | - | 2062233..2063489 (-) | 1257 | WP_001795438.1 | aminopeptidase | - |
| FF958_RS10505 (FF958_10505) | - | 2063492..2063692 (-) | 201 | WP_000180461.1 | DUF1128 family protein | - |
| FF958_RS10510 (FF958_10510) | - | 2063839..2064303 (+) | 465 | WP_000228666.1 | low molecular weight protein-tyrosine-phosphatase | - |
| FF958_RS10515 (FF958_10515) | - | 2064310..2064585 (+) | 276 | WP_000428172.1 | YtxH domain-containing protein | - |
| FF958_RS10520 (FF958_10520) | - | 2064863..2066080 (+) | 1218 | WP_000037075.1 | YihY/virulence factor BrkB family protein | - |
| FF958_RS10525 (FF958_10525) | vraR | 2066196..2066825 (-) | 630 | WP_000153530.1 | two-component system response regulator VraR | Regulator |
| FF958_RS10530 (FF958_10530) | vraS | 2066815..2067858 (-) | 1044 | WP_001017131.1 | sensor histidine kinase | Regulator |
| FF958_RS10535 (FF958_10535) | liaF | 2067855..2068556 (-) | 702 | WP_000149064.1 | cell wall-active antibiotics response protein LiaF | - |
| FF958_RS10540 (FF958_10540) | - | 2068571..2068957 (-) | 387 | WP_001110179.1 | hypothetical protein | - |
| FF958_RS10545 (FF958_10545) | map | 2069174..2069932 (-) | 759 | WP_000636142.1 | type I methionyl aminopeptidase | - |
| FF958_RS10550 (FF958_10550) | - | 2070519..2071505 (+) | 987 | WP_000999713.1 | aromatic acid exporter family protein | - |
| FF958_RS10555 (FF958_10555) | - | 2071936..2072349 (-) | 414 | WP_001549145.1 | hypothetical protein | - |
| FF958_RS10560 (FF958_10560) | - | 2072378..2072488 (-) | 111 | WP_001790257.1 | hypothetical protein | - |
| FF958_RS10565 (FF958_10565) | - | 2072574..2073305 (-) | 732 | WP_000544967.1 | type 1 glutamine amidotransferase | - |
| FF958_RS10570 (FF958_10570) | murT | 2073307..2074620 (-) | 1314 | WP_001250336.1 | lipid II isoglutaminyl synthase subunit MurT | - |
| FF958_RS10575 (FF958_10575) | ftnA | 2074912..2075412 (+) | 501 | WP_000949467.1 | H-type ferritin FtnA | - |
| FF958_RS10580 (FF958_10580) | - | 2075771..2076325 (+) | 555 | WP_000613733.1 | 3'-5' exonuclease | - |
| FF958_RS10585 (FF958_10585) | dinB | 2076393..2077463 (-) | 1071 | WP_000140176.1 | DNA polymerase IV | - |
| FF958_RS10590 (FF958_10590) | - | 2077710..2078240 (-) | 531 | WP_000548781.1 | DUF3267 domain-containing protein | - |
| FF958_RS10595 (FF958_10595) | rlmD | 2078410..2079771 (-) | 1362 | WP_001147868.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| FF958_RS10600 (FF958_10600) | - | 2079852..2080799 (-) | 948 | WP_001231451.1 | diacylglycerol kinase | - |
| FF958_RS10605 (FF958_10605) | - | 2081382..2081528 (-) | 147 | WP_001797372.1 | hypothetical protein | - |
| FF958_RS10610 (FF958_10610) | gatB | 2081568..2082995 (-) | 1428 | WP_000545370.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB | - |
| FF958_RS10615 (FF958_10615) | gatA | 2083008..2084465 (-) | 1458 | WP_000027928.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| FF958_RS10620 (FF958_10620) | gatC | 2084467..2084769 (-) | 303 | WP_000170162.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| FF958_RS10625 (FF958_10625) | putP | 2085136..2086674 (+) | 1539 | WP_000957015.1 | sodium/proline symporter PutP | - |
| FF958_RS10630 (FF958_10630) | - | 2086763..2087962 (-) | 1200 | WP_000831698.1 | CamS family sex pheromone protein | - |
| FF958_RS10635 (FF958_10635) | ligA | 2087975..2089978 (-) | 2004 | WP_000774565.1 | NAD-dependent DNA ligase LigA | - |
| FF958_RS10640 (FF958_10640) | pcrA | 2089982..2092174 (-) | 2193 | WP_000992921.1 | DNA helicase PcrA | - |
| FF958_RS10645 (FF958_10645) | - | 2092171..2092863 (-) | 693 | WP_000272068.1 | heptaprenylglyceryl phosphate synthase | - |
| FF958_RS10650 (FF958_10650) | - | 2093035..2093337 (-) | 303 | WP_001165363.1 | YerC/YecD family TrpR-related protein | - |
| FF958_RS10655 (FF958_10655) | purB | 2093446..2094741 (-) | 1296 | WP_000572878.1 | adenylosuccinate lyase | - |
| FF958_RS10665 (FF958_10665) | scpA | 2095602..2096768 (+) | 1167 | WP_000827748.1 | cysteine protease staphopain A | - |
| FF958_RS10670 (FF958_10670) | - | 2096799..2097125 (+) | 327 | WP_000434933.1 | staphostatin A | - |
| FF958_RS10675 (FF958_10675) | - | 2097417..2097590 (-) | 174 | WP_000669862.1 | NETI motif-containing protein | - |
| FF958_RS10680 (FF958_10680) | - | 2097571..2098173 (-) | 603 | WP_000011542.1 | DUF2179 domain-containing protein | - |
| FF958_RS10685 (FF958_10685) | nadE | 2098444..2099265 (-) | 822 | WP_000040873.1 | ammonia-dependent NAD(+) synthetase | - |
| FF958_RS10690 (FF958_10690) | - | 2099258..2100727 (-) | 1470 | WP_000284431.1 | nicotinate phosphoribosyltransferase | - |
Sequence
Protein
Download Length: 209 a.a. Molecular weight: 23545.29 Da Isoelectric Point: 5.3889
>NTDB_id=365877 FF958_RS10525 WP_000153530.1 2066196..2066825(-) (vraR) [Staphylococcus aureus strain JKD6004]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
Nucleotide
Download Length: 630 bp
>NTDB_id=365877 FF958_RS10525 WP_000153530.1 2066196..2066825(-) (vraR) [Staphylococcus aureus strain JKD6004]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| vraR | Staphylococcus aureus N315 |
99.522 |
100 |
0.995 |
| degU | Bacillus subtilis subsp. subtilis str. 168 |
34.821 |
100 |
0.373 |