Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   SMI_RS10310 Genome accession   NC_013853
Coordinates   2101481..2103913 (-) Length   810 a.a.
NCBI ID   WP_001109716.1    Uniprot ID   D3HBN1
Organism   Streptococcus mitis B6     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 2096481..2108913
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS10280 (smi_2039) - 2096633..2097319 (-) 687 WP_000764011.1 YoaK family protein -
  SMI_RS10285 (smi_2040) - 2097446..2098144 (-) 699 WP_000730890.1 hypothetical protein -
  SMI_RS10290 (smi_2041) - 2098423..2098653 (+) 231 WP_000949600.1 hypothetical protein -
  SMI_RS10295 (smi_2042) - 2098726..2099499 (-) 774 WP_000140989.1 NUDIX domain-containing protein -
  SMI_RS10300 (smi_2043) pnuC 2099501..2100280 (-) 780 WP_000736873.1 nicotinamide riboside transporter PnuC -
  SMI_RS10305 (smi_2044) - 2100290..2101348 (-) 1059 WP_000730572.1 AAA family ATPase -
  SMI_RS10310 (smi_2045) clpC 2101481..2103913 (-) 2433 WP_001109716.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SMI_RS10315 (smi_2046) - 2103915..2104373 (-) 459 WP_001211269.1 CtsR family transcriptional regulator -
  SMI_RS10320 (smi_2047) - 2104492..2105220 (-) 729 WP_000136214.1 ABC transporter ATP-binding protein -
  SMI_RS10325 (smi_2048) - 2105220..2106227 (-) 1008 WP_000754539.1 ABC transporter substrate-binding protein -
  SMI_RS10330 (smi_2049) - 2106265..2107023 (-) 759 WP_001245124.1 ABC transporter permease -
  SMI_RS10335 (smi_2050) - 2106986..2107276 (-) 291 WP_000647665.1 thiamine-binding protein -
  SMI_RS10340 (smi_2051) cbpD 2107530..2108648 (-) 1119 WP_000866454.1 choline binding-anchored murein hydrolase CbpD -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90233.05 Da        Isoelectric Point: 6.0158

>NTDB_id=36346 SMI_RS10310 WP_001109716.1 2101481..2103913(-) (clpC) [Streptococcus mitis B6]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETNYSQDETFTELPF
SHRLQVLFDEAEYVASVVHAKMLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMAILQGLKVTYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSGLSPADKALMDGKWKQATQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVRPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGNTLKIGI
KAGQLKFDIV

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=36346 SMI_RS10310 WP_001109716.1 2101481..2103913(-) (clpC) [Streptococcus mitis B6]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGCCATTTTGGAGCTCGTTACCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCCAATCACAGTTATAGTGTGGCAGGGGCAACTTTAAATGATTATCCATATGAGA
TGGACCGTTTAGAAGAGGTCGCTTTGGAACTGACTGAAACGAACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTT
TCTCATCGTTTGCAGGTTCTTTTTGACGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGATGCTAGGGACGGAGCA
CGTCCTTTATGCGATTTTGCATGATGGAAATGCCTTGGCGACTCGTATTTTGGAGAGGGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCTCTTCGTCGAAATTTAGAAGAACGGGCAGGCTGGACCCGTGAAGACCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGATAAGCAAAATTCTATGGCTAATATGATGGGCATGCCCCAGACTCCGAGTGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATTGGTCGAGATAAGG
AAATCTCGCGTATGATTCAAATCTTGAGCCGTAAGACCAAGAATAATCCTGTCTTGGTTGGAGATGCTGGTGTTGGGAAA
ACTGCTCTGGCGCTTGGTCTTGCCCAGCGTATTGCTAGTGGGGATGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTGGA
GCTGGATTTGATGAATGTCGTTGCAGGGACACGTTTTCGTGGTGACTTTGAAGAACGCATGAACAATATCATCAAGGATA
TTGAGGAAGATGGGCAAGTCATCCTCTTTATCGATGAACTTCATACCATCATGGGTTCTGGGAGCGGGATTGACTCAACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGTACCTTGAGAACGGTTGGCGCGACCACTCAGGAGGAATA
CCAAAAACATATCGAAAAAGATGCGGCCCTTTCTCGTCGTTTCGCCAAAGTAACGATTGAAGAGCCAAGCGTGGCCGACA
GTATGGCGATTTTGCAAGGTTTGAAGGTGACTTATGAGAAACACCACCGTGTGCAAATCACAGATGAAGCGGTTGAAACA
GCCGTTAAGATGGCCCATCGTTACTTGACTAGTCGCCATTTGCCAGACTCTGCTATCGATCTCTTGGATGAGGCAGCAGC
AACAGTGCAAAATAAGGCTAAGCATGTAAAAGCAGACGATTCAGGTTTGAGTCCAGCTGACAAGGCCTTGATGGATGGTA
AGTGGAAACAAGCTACTCAACTAATTGCTAAAGAAGAGGAAGTGCCTGTCTATAAAGACTTGGTGACGGAGTCTGATATT
TTGACCACCTTGAGTCGCTTGTCAGGCATTCCAGTCCAAAAACTGACTCAGACTGATGCGAAGAAATACCTGAATCTGGA
AGCTGAATTGCACAAACGTGTCATCGGTCAAGATCAAGCTGTTTCAAGCATTAGCCGTGCGATTCGCCGCAACCAGTCAG
GGATTCGCAGTCACAAGCGTCCGATTGGTTCCTTTATGTTCCTAGGACCTACAGGTGTCGGTAAGACCGAATTGGCCAAG
GCTCTGGCGGAAGTTCTCTTTGATGACGAATCAGCTCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTTGCAGC
CAGCCGTCTCAATGGAGCTCCTCCGGGCTATGTGGGCTACGAAGAAGGTGGGGAGTTGACCGAGAAAGTTCGCAACAAAC
CATACTCTGTTCTCCTCTTTGACGAGGTAGAGAAGGCCCATCCAGATATCTTTAATGTTCTCTTGCAGGTCTTGGATGAT
GGTGTCTTGACCGATAGCAAGGGCCGCAAGGTTGACTTTTCAAATACCATTATTATCATGACGTCAAATCTTGGTGCGAC
AGCTCTTCGTGATGACAAGACAGTTGGTTTTGGGGCTAAGGACATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAGCTGAAAAAAGCTTATAGACCTGAGTTTATTAACCGTATTGATGAGAAGGTGGTCTTCCATAGCCTTTCTAGC
GACCATATGCAGGAAGTAGTGAAGATTATGGTCAGACCTTTAGTGGCAAGTTTGGCTGAAAAAGGTATTGACTTGAAATT
ACAAGCTTCCGCACTGAAATTGTTGGCCAATCAAGGATATGACCCAGAGATGGGAGCTCGTCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAAGACAAGTTAGCAGAACTTCTTCTCAAGGGAGATTTAGTGGCAGGCAACACACTTAAGATTGGTATC
AAAGCAGGCCAGTTAAAATTTGATATTGTATAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(102-139)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

AAA lid domain (AAA_lid_9)

(370-439)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3HBN1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae TIGR4

98.517

99.877

0.984
  clpC Streptococcus pneumoniae Rx1

98.517

99.877

0.984
  clpC Streptococcus pneumoniae D39

98.517

99.877

0.984
  clpC Streptococcus mutans UA159

67.199

100

0.675
  clpC Streptococcus thermophilus LMD-9

66.012

100

0.664
  clpC Streptococcus thermophilus LMG 18311

65.89

100

0.663
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.854

100

0.5
  clpC Bacillus subtilis subsp. subtilis str. 168

44.87

99.877

0.448
  clpE Streptococcus mutans UA159

49.032

76.543

0.375
  clpE Streptococcus pneumoniae Rx1

46.975

77.531

0.364
  clpE Streptococcus pneumoniae D39

46.975

77.531

0.364
  clpE Streptococcus pneumoniae R6

46.975

77.531

0.364
  clpE Streptococcus pneumoniae TIGR4

46.975

77.531

0.364

Multiple sequence alignment