Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   SMI_RS04365 Genome accession   NC_013853
Coordinates   820713..822971 (-) Length   752 a.a.
NCBI ID   WP_000882502.1    Uniprot ID   -
Organism   Streptococcus mitis B6     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 815713..827971
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS04345 (smi_0861) ezrA 817232..818959 (+) 1728 WP_000016768.1 septation ring formation regulator EzrA -
  SMI_RS04350 (smi_0862) - 819005..819637 (-) 633 WP_000502302.1 GNAT family N-acetyltransferase -
  SMI_RS04355 (smi_0863) - 819773..820072 (-) 300 WP_000767189.1 DUF1827 family protein -
  SMI_RS04360 (smi_0864) - 820131..820583 (-) 453 WP_000013084.1 NUDIX hydrolase -
  SMI_RS04365 (smi_0865) clpE 820713..822971 (-) 2259 WP_000882502.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SMI_RS04370 (smi_0866) - 823200..823430 (-) 231 WP_000443570.1 DUF1797 family protein -
  SMI_RS04375 (smi_0867) - 823623..824306 (+) 684 WP_001011616.1 amino acid ABC transporter permease -
  SMI_RS04380 (smi_0868) - 824306..825040 (+) 735 WP_000140955.1 amino acid ABC transporter ATP-binding protein -
  SMI_RS04385 (smi_0869) - 825218..826075 (+) 858 WP_000192103.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  SMI_RS04390 (smi_0870) - 826213..827034 (+) 822 WP_000601065.1 hypothetical protein -
  SMI_RS04395 (smi_0871) - 827049..827900 (+) 852 WP_000863093.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83802.31 Da        Isoelectric Point: 5.3741

>NTDB_id=36313 SMI_RS04365 WP_000882502.1 820713..822971(-) (clpE) [Streptococcus mitis B6]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSNNTPPTPP
TQSGGGYGGNGGYGSQNRGPAQTPPPSQEKGLLEEFGINITEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLSDVNKRLSSNNIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDFYLENP
SEKDLKAVMTSKGKIQIKSAKKAEVKTSEKEV

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=36313 SMI_RS04365 WP_000882502.1 820713..822971(-) (clpE) [Streptococcus mitis B6]
ATGCTTTGTCAAAACTGTAAAATCAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTACAAGATTATCAAAACAGATCCTAACAATAGCCTCTTTAAAGGTATGACAGATCTGAACAATC
GTGACTTTGATCCTTTTGGGGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAACAACACTCCTCCTACTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGACCTGCTCAAACTCCTCCACCAAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATCAACATAACTGAAATTGCCCGTCGTGGCGATATTGACCCCGTTATTG
GGCGCGATGATGAGATTATCCGTGTCATCGAAATTCTCAATCGTAGAACTAAGAATAATCCTGTTCTTATCGGTGAACCA
GGTGTCGGGAAAACGGCTGTTGTCGAAGGTCTAGCTCAGAAAATCGTTGATGGAGATGTTCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTGGTTCAAGGAACGGGTATCCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATTATTCTCTTTATAGATGAAATCCATGAAATTGTCGGTGCAGGTTCTGCT
GGCGATGGCAATATGGATGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGGGAACTGCAACTGGTCGGTGCCACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCCGCCCTAGAGCGTCGTATGCAACCTGTTAAGGTCGATGAACCAACTG
TGGAAGAAACAATCACTATCCTCAAAGGAATTCAAAAGAAATACGAAGACTACCACCACGTTCAGTATACCGATGCTGCT
ATCGAAGCAGCTGCAACTCTTTCCAATCGTTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCCTGAATTTTGTAGATCCTAAAGTGATTGACCAGCGCTTGATTGAGGCTGAAAATC
TCAAATCTCAAGCTACACGAGAGGAAGATTTTGAGAAGGCCGCCTACTTCCGTGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGGTCACAGACCAGGACACTCCTATCATCAGTGAGAAAACCATTGAGCACATTATCGAGCAGAAAACCAA
CATTCCTGTTGGCGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTCATTG
GACAAGATGATGCTGTCGATAAGATTGCCAAGGCTATTCGCCGGAATCGTGTCGGTCTCGGTACGCCTAACCGCCCAATC
GGAAGCTTCCTCTTTGTCGGACCAACTGGGGTCGGTAAGACAGAACTTTCCAAACAATTAGCTATCGAACTCTTTGGTTC
TGCTGATAGCATGATTCGCTTTGACATGAGCGAATACATGGAAAAACACAGCGTAGCTAAGTTGGTCGGCGCCCCTCCAG
GTTATGTTGGCTACGATGAGGCTGGGCAATTAACTGAAAAAGTTCGTCGCAATCCATATTCTCTTATTCTCTTGGATGAA
GTAGAGAAAGCCCATCCAGATGTTATGCATATGTTCCTACAAGTCTTGGACGATGGTCGTTTGACAGATGGGCAAGGACG
TACCGTTAGCTTCAAGGATGCCATCATTATCATGACTTCAAATGCAGGGACAGGTAAGGCCGAAGCCAGCGTTGGTTTCG
GGGCAGCTCGCGAAGGACGGACCAACTCTGTTCTCGGTGAACTCGGCAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTTATGCTATCAGACGTTAACAA
GCGCCTTTCTAGCAACAACATTCATTTAGATGTAACTGAAAAGGTCAAGGAAAAATTGGTTGACCTCGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGTACTATTCAAGACTATATTGAGGACGCAATCACTGACTTCTACCTTGAAAATCCA
AGCGAAAAAGACCTCAAGGCAGTTATGACCAGCAAGGGCAAGATTCAAATTAAGTCTGCCAAAAAAGCTGAAGTAAAAAC
TTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

97.87

99.867

0.977
  clpE Streptococcus pneumoniae D39

97.87

99.867

0.977
  clpE Streptococcus pneumoniae R6

97.87

99.867

0.977
  clpE Streptococcus pneumoniae TIGR4

97.736

99.867

0.976
  clpE Streptococcus mutans UA159

83.467

99.734

0.832
  clpC Lactococcus lactis subsp. cremoris KW2

75.889

100

0.766
  clpC Bacillus subtilis subsp. subtilis str. 168

50.359

92.686

0.467
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.847

83.378

0.399
  clpC Streptococcus pneumoniae TIGR4

47.293

83.511

0.395
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus mutans UA159

46.73

83.378

0.39
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386

Multiple sequence alignment