Detailed information NTG0362720

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FD746_RS10485
• Genome accession: NZ_CP040232
• Coordinates: 2069743..2070786 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GD1706
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2064743..2075786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FD746_RS10455 (FD746_10480)	-	2065164..2066420 (-)	1257	WP_001793428.1	aminopeptidase	-
FD746_RS10460 (FD746_10485)	-	2066423..2066623 (-)	201	WP_000180460.1	DUF1128 family protein	-
FD746_RS10465 (FD746_10490)	-	2066770..2067234 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FD746_RS10470 (FD746_10495)	-	2067241..2067516 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FD746_RS10475 (FD746_10500)	-	2067794..2069011 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
FD746_RS10480 (FD746_10505)	vraR	2069124..2069753 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
FD746_RS10485 (FD746_10510)	vraS	2069743..2070786 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FD746_RS10490 (FD746_10515)	liaF	2070783..2071484 (-)	702	WP_031886362.1	cell wall-active antibiotics response protein LiaF	-
FD746_RS10495 (FD746_10520)	-	2071499..2071885 (-)	387	WP_001110182.1	hypothetical protein	-
FD746_RS10500 (FD746_10525)	map	2072102..2072860 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
FD746_RS10505 (FD746_10530)	-	2073444..2074430 (+)	987	WP_000999712.1	FUSC family protein	-
FD746_RS10510 (FD746_10535)	-	2074619..2075032 (-)	414	WP_025174370.1	hypothetical protein	-
FD746_RS10515 (FD746_10540)	-	2075061..2075171 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=362720 FD746_RS10485 WP_001017131.1 2069743..2070786(-) (vraS) [Staphylococcus aureus strain GD1706]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=362720 FD746_RS10485 WP_001017131.1 2069743..2070786(-) (vraS) [Staphylococcus aureus strain GD1706]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1