Detailed information NTG0362567

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FD491_RS00445
• Genome accession: NZ_CP040230
• Coordinates: 81099..82142 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GD1108
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76099..87142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FD491_RS00415 (FD491_09560)	-	76824..76934 (+)	111	WP_014937049.1	hypothetical protein	-
FD491_RS00420 (FD491_09555)	-	76963..77376 (+)	414	WP_025174370.1	hypothetical protein	-
FD491_RS00425 (FD491_09550)	-	77565..78551 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
FD491_RS00430 (FD491_09545)	map	79025..79783 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
FD491_RS00435 (FD491_09540)	-	80000..80386 (+)	387	WP_001110182.1	hypothetical protein	-
FD491_RS00440 (FD491_09535)	liaF	80401..81102 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FD491_RS00445 (FD491_09530)	vraS	81099..82142 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FD491_RS00450 (FD491_09525)	vraR	82132..82761 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
FD491_RS00455 (FD491_09520)	-	82874..84091 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
FD491_RS00460 (FD491_09515)	-	84369..84644 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
FD491_RS00465 (FD491_09510)	-	84651..85115 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FD491_RS00470 (FD491_09505)	-	85262..85462 (+)	201	WP_000180460.1	DUF1128 family protein	-
FD491_RS00475 (FD491_09500)	-	85465..86721 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=362567 FD491_RS00445 WP_001017131.1 81099..82142(+) (vraS) [Staphylococcus aureus strain GD1108]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=362567 FD491_RS00445 WP_001017131.1 81099..82142(+) (vraS) [Staphylococcus aureus strain GD1108]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1